Effectiveness of sotalol in preventing supraventricular tachyarrhythmias shortly after coronary artery bypass grafting

Suttorp, Maarten J.; Kingma, J. H.; Peels, Hans O.; Koomen, Egbert M.; Tijssen, Jan G.P.; Hemel, Norbert M. van; Defauw, Jo J.A.M.; Ernst, Sjef M.P.G.

doi:10.1016/0002-9149(91)90188-q

Cited by 129 publications

(36 citation statements)

References 28 publications

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“…Some studies specifically addressed this question. In comparative studies, the prophylactic use of sotalol was associated with a lower frequency of postoperative AF (Table 1) as well as less postoperative supraventricular tachycardia (SVT) [18][19][20][21] . In one study, sotalol appeared to be more effective than propranolol in preventing SVT, but the difference did not reach statistical significance 22 .…”

Section: Sotalolmentioning

confidence: 99%

Atrial fibrillation post-cardiac surgery: changing perspectives

Shantsila

Watson

Lip

2006

Current Medical Research and Opinion

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Section: Sotalolmentioning

confidence: 99%

Atrial fibrillation post-cardiac surgery: changing perspectives

Shantsila

Watson

Lip

2006

Current Medical Research and Opinion

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“…Four other trials [5][6][7][8] that directly compared ␤-blockers and sotalol were identified and analyzed separately.…”

Section: Inclusion Criteria For Studiesmentioning

confidence: 99%

“…[5][6][7][8] Sotalol reduced the percentage of patients with AF from 22% in the other ␤-blocker group to 12% in sotalol group (OR, 0.50; 95% CI, 0.34 to 0.74), with no significant heterogeneity (Pϭ0.33)…”

Section: Sotalol Versus Conventional ␤-Blockersmentioning

confidence: 99%

Interventions on Prevention of Postoperative Atrial Fibrillation in Patients Undergoing Heart Surgery

et al. 2002

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Background-Postoperative atrial fibrillation (AF) is a common complication of cardiac surgery and has been associated with increased incidence of other complications and increased hospital length of stay (LOS). Prevention of AF is a reasonable clinical goal, and, consequently, many randomized trials have evaluated the effectiveness of pharmacological and nonpharmacological interventions for prevention of AF. To better understand the role of various prophylactic therapies against postoperative AF, a systematic review of evidence from randomized trials was performed. Methods and Results-Fifty-two randomized trials (controlled by placebo or routine treatment) of ␤-blockers, sotalol, amiodarone, or pacing were identified by systematic literature search.

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“…Another antiarrhythmic agent used for the prevention of atrial fibrillation in cardiac surgery patients is sotalol which was shown to reduce the incidence of postoperative atrial fibrillation (Burgess et al, 2006; compared to placebo or to other betablocker such as atenolol (Sanjuan et al, 2004), metoprolol (Parikka et al, 1998) or propranolol (Suttorp et al, 1990) but it had no impact on length of hospital stay, risk of strokes, or mortality . However, the use of sotalol in postoperative atrial fibrillation is limited because of its significant side effects such as bradycardia and torsade de pointes, especially in patients with electrolyte disturbances.…”

Section: Discussionmentioning

confidence: 99%