Ivabradine Versus Beta-Blockers in Patients with Conduction Abnormalities or Left Ventricular Dysfunction Undergoing Coronary Artery Bypass Grafting

Iliuță, Luminița; Enache, Roxana

doi:10.5772/25932

Cited by 4 publications

(4 citation statements)

References 32 publications

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“…In a retrospective study (n= 20), McDonald et al reported symptomatic improvement in 60% of PoTS patients [80]. Recently, it has been demonstrated in a single center trial that ivabradine has improved the quality of life in patients undergoing coronary artery bypass grafting associated with conduction abnormalities (first degree atrioventricular block or bundle branch block) or left ventricular dysfunction with relative or absolute contraindications to β-blockers [84]. In acute heart failure due to myocarditis: In a few cases [65], ivabradine was administered as an adjuvant off-label to patients with acute heart failure and multiorgan failure due to myocarditis; it has proven to be beneficial in supporting hemodynamic stabilization [66].…”

Section: Ivabradine Use In Different Disordersmentioning

confidence: 99%

“…Atrial fibrillation (AF): Martin et al performed a meta-analysis of 21,571 patients which demonstrated that ivabradine treatment was associated with a relative risk of 15% of developing AF [87]. On the other hand, Ivabradine in combination with Metoprolol was more effective (7.6%) than ivabradine (17.1%) or metoprolol (11.5%) alone in the prevention of postoperative atrial fibrillation in patients undergoing coronary artery bypass surgery [84]. …”

Section: Profile Of Ivabradine: Electrophysiological Propertiesmentioning

confidence: 99%

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Ivabradine in Takotsubo cardiomyopathy

Saïd¹

2017

IJCC

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Abstract:AIM: The aim of this review is to present a case report of Takotsubo cardiomyopathy and to review the current literature. The second aim is to describe the role of ivabradine in the management of Takotsubo cardiomyopathy when intolerance for beta blockers occurs. MATERIALS: Case report and literature review of Takotsubo cardiomyopathy. RESULTS: A 52-year-old Caucasian female presented with Takotsubo cardiomyopathy triggered by severe emotional stress. Dmission electrocardiogram mimicked acute ST-segment elevation myocardial infarction , coronary angiography excluded significant coronary stenosis and left ventriculogram showed a typical Takotsubo cardiomyopathy apical ballooning appearance. Due to beta blocker intolerance, "off-label" treatment with ivabradine was initiated because of symptomatic sinus tachycardia. Echocardiography revealed normalization of the ejection fraction at outpatient follow-up. In the recent literature, ivabradine has been used in the management of different entities such as stable angina pectoris, congestive heart failure, inappropriate sinus tachycardia syndrome, postural tachycardia syndrome and Takotsubo cardiomyopathy. CONCLUSION: Takotsubo cardiomyopathy may be induced by witnessing a robbery. The patient was intolerant for beta blockers and had a favorable response to treatment with ivabradine. Ivabradine may be an alternative choice in cases where there is an intolerance of beta blockers. We present an exceedingly rare case of Takotsubo cardiomyopathy induced by uncommon severe emotional stress, catching her colleague stealing money from the cash register, which was associated with sinus tachycardia in a female patient with intolerance for beta blockers. The patient responded well to treatment with oral ivabradine. The literature is briefly reviewed

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Section: Ivabradine Use In Different Disordersmentioning

confidence: 99%

Section: Profile Of Ivabradine: Electrophysiological Propertiesmentioning

confidence: 99%

Ivabradine in Takotsubo cardiomyopathy

Saïd¹

2017

IJCC

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“…Coronary endarterectomy (CE) was initially described in 1957 by Bailey as a technique to achieve complete myocardial revascularization in patients with diffusely diseased coronary arteries [ 1 ]. Studies regarding the safety and necessity of this procedure are controversial and a standard technique of CE on the LAD has not yet been established [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. There is an increased risk of postoperative myocardial infarction when CE is performed on the LAD with potential fatal consequences [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Open Coronary Endarterectomy of Left Anterior Descending Artery—Case Report and Review of Literature

Robu

Marian

Lazăr

et al. 2022

JCDD

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Coronary endarterectomy (CE) emerged as a necessity to achieve complete surgical myocardial revascularization in patients with diffusely diseased coronary arteries and it also serves as aid to coronary bypass grafting (CABG). The safety and postoperative prognosis of this procedure are still matters of debate. There are no clear preoperative indications, a standard technique has not yet been established as gold standard and the postoperative management differs depending on each institution. CE of the left anterior descending artery (LAD) is technically challenging and potentially hazardous with high risk of postoperative myocardial infarction. In this article, we describe the open technique for CE of the LAD with its specific details, which we believe could be the safest and the best reproductible option. To better understand the profile of a patient requiring such a procedure we present the case of a 73-years old male with diffused coronary artery disease (CAD) and a short review of literature.

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“…По данным Iliuta L. и соавт. у пациентов с нарушениями проводимости или дисфункцией ЛЖ, подвергшихся аорто-коронарному шунтированию, при дооперационном использовании ивабрадина на-блюдалось меньше предсердных и желудочковых аритмий по сравнению с метопрололом [12]. Murat S. и соавт.…”

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Comparative efficacy of amiodarone with ivabradin combination or amiodarone with bisoprolol combination in the prevention of atrial fibrillation recurrence in pa- tients with left ventricular diastolic dysfunction

Adamyan¹,

Tunyan²,

Chilingaryan³

2015

Racionalʹnaâ farmakoterapiâ v kardiologii

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ВведениеДиастолическая дисфункция левого желудочка (ЛЖ) является частой причиной фибрилляции предсердий (ФП) в результате гиперактивности/перегрузки (функ-ционального ремоделирования) левого предсердия (ЛП) для адекватного наполнения ЛЖ [1], а в последую-щем -и структурного ремоделирования ЛП, проявляю-щегося дилатацией и изменениями миокарда [1][2][3].При диастолической дисфункции ЛЖ роль систолы ЛП становится особенно важной, и ФП, при которой ЛП становится механически нефункциональным, приводит к значительному уменьшению наполнения ЛЖ, а, сле-довательно, и к уменьшению его систолического вы-броса. Это приводит к клиническим проявлениям сер-дечной недостаточности [4].Антиаритмические препараты и их комбинации поддерживают восстановленный синусовый ритм в Цель. Изучить эффективность комбинации амиодарона с ивабрадином и комбинации амиодарона с бисопрололом в профилактике рецидивов фибрилляции пред-сердий (ФП) у пациентов с диастолической дисфункцией (ДД) левого желудочка (ЛЖ) после восстановления синусового ритма. Материал и методы. В исследование включены 65 пациентов (40 мужчин, 25 женщин) в возрасте 53±8 лет с персистирующей ФП и ДДЛЖ, рандомизированные в три группы, для получения ивабрадина и амиодарона (22 пациента), бисопролола и амиодарона (22 пациента) и только амиодарона (21 пациент). После периода титрации, а также через 3 и 6 мес вычисляли индексы объемов левого предсердия (ЛП), скорость продольной деформации ЛП в систолу (СДс), индекс массы ЛЖ, и проводилось ЭКГ мониторирование с определением средней ЧСС, вариабельности сердечного ритма за 24 час, а также регистрации эпизодов ФП за 96 час. Результаты. Через 6 мес наблюдения в 1 группе наблюдались значимо меньшие индекс максимального объема ЛП (21,3±2,4 против 25,2±3,0 и 28,7±3,6 мл/м 2 во 2 и контрольной группах, соответственно), индекс объема ЛП в начале ЭКГ P зубца (15,3±3,5 против 18,1±3,8 и 20,4±4,0 мл/м 2 во 2 и контрольной группах, со-ответственно), и индекс ударного объема ЛП (7,3±1,2 против 9,4±1,6 и 9,6±1,7 мл/м 2 во 2 и контрольной группах, соответственно). Частота побочных эффектов в 1 группе была значимо меньше, чем во 2 группе, и не различалась по сравнению с контрольной группой. Заключение. Комбинация ивабрадина с амиодароном обеспечивает лучшую профилактику ФП у больных с ДДЛЖ и персистирующей ФП после восстановления си-нусового ритма с меньшими побочными эффектами по сравнению с комбинацией бисопролола с амиодароном, а также обеспечивает снижение максимального, про-точного и ударного объемов ЛП, с повышением СДс. Aim.To study the efficacy of use of amiodarone with ivabradine combination or amiodarone with bisoprolol combination in the prevention of atrial fibrillation (AF) recurrence in patients (pts) with left ventricular diastolic dysfunction (LVDD) after conversion to sinus rhythm. Material and methods. 65 patients (40 males, 25 females) aged 53±8 years with persistent AF and LVDD were included into the study and randomized into 3 groups to receive ivabradine and amiodarone (22 pts), bisoprolol and amiodarone (22 pts) or amiodaro...

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Ivabradine Versus Beta-Blockers in Patients with Conduction Abnormalities or Left Ventricular Dysfunction Undergoing Coronary Artery Bypass Grafting

Cited by 4 publications

References 32 publications

Ivabradine in Takotsubo cardiomyopathy

Ivabradine in Takotsubo cardiomyopathy

Open Coronary Endarterectomy of Left Anterior Descending Artery—Case Report and Review of Literature

Comparative efficacy of amiodarone with ivabradin combination or amiodarone with bisoprolol combination in the prevention of atrial fibrillation recurrence in pa- tients with left ventricular diastolic dysfunction

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