Effectiveness of red clover in alleviating menopausal symptoms: a 12-week randomized, controlled trial

Shakeri, Fatemeh; Taavoni, S.; Goushegir, Ashrafeddin; Haghani, Hamid

doi:10.3109/13697137.2014.999660

Cited by 35 publications

(31 citation statements)

References 40 publications

(31 reference statements)

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“…Furthermore, a recent randomized, placebo‐controlled clinical trial involving 72 healthy postmenopausal women revealed a significant reduction in severity of menopausal symptoms, determined by the Menopause Rating Scale (MRS). The therapy included a daily dose of two capsules with 40 mg of dried leaves of red clover, for 12 weeks …”

Section: Estrogenic Effects Of Trifolium Plantsmentioning

confidence: 99%

“…The therapy included a daily dose of two capsules with 40 mg of dried leaves of red clover, for 12 weeks. [71] Research on the effects of Trifolium plant-derived compounds on bone physiology has provided conflicting data. No beneficial effects of biochanin A administration on skeletal system were found in studies on animal model of osteoporosis.…”

Section: Clovers and Menopause-related Disorders: The Newest In-vivo mentioning

confidence: 99%

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Trifoliumspecies – the latest findings on chemical profile, ethnomedicinal use and pharmacological properties

Kołodziejczyk-Czepas

2016

Journal of Pharmacy and Pharmacology

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Objectives Clovers (Trifolium, Fabaceae) have a long history of use in folk medicine. Furthermore, during last 3 years, a considerable growth in scientific interest in these plants has been observed. This article summarizes and critically reviews an over 3-year progress of knowledge of ethnomedicinal use, phytochemical profile, physiological effects and possible therapeutic action of various clover species. It contains the latest literature (over 80 papers), originated from international databases

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Section: Estrogenic Effects Of Trifolium Plantsmentioning

confidence: 99%

Section: Clovers and Menopause-related Disorders: The Newest In-vivo mentioning

confidence: 99%

Trifoliumspecies – the latest findings on chemical profile, ethnomedicinal use and pharmacological properties

Kołodziejczyk-Czepas

2016

Journal of Pharmacy and Pharmacology

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“…The glycosidic forms of isoflavones are hydrolyzed by intestinal bacteria and enzymes and further metabolized through glucuronidation within the liver [50]. Daidzein is metabolized in the liver to equol or o-desmethylangolensin (O-DMA) and genistein to pethyl phenol [51], three potent phytoestrogens derivatives that can be detected in human serum and urine [37]. In our study, S4 contains glycosidic forms of isoflavones, namely genistin, daidzin, and glycerin.…”

Section: Resultsmentioning

confidence: 88%

“…in reducing the severity of menopausal symptoms [37]. The systematic review and meta-analysis by Ghazanfarpour et al [38] concluded that consumption of red clover is effective in decreasing hot flashes, especially in women with severe hot flashes ( ≥ 5 per day).…”

Section: Resultsmentioning

confidence: 99%

Estrogenic and Antiestrogenic Activities of Commercial Dietary Supplements Containing Herbal Ingredients and Isoflavones

Basu

Sunny

Maier

2016

Int J Pharm Pharm Sci

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Objective: This study aimed to assess the estrogenic and antiestrogenic activities of five dietary supplements, commercially available for treatment of menopausal symptoms, before and after gastrointestinal digestion by employing a yeast steroid-regulated transcription system. Methods: Supplements (S) were extracted with either 80% methanol or water. Water extracts were subjected to simulated gastrointestinal (GI) digestion. Estrogenic and antiestrogenic activities were assessed by a steroid-regulated transcription system in Saccharomyces cerevisiae expressing the human estrogen receptor alpha. Results:The highest estrogenic activities were detected in both S1 methanol (2342.5±20.83 MU) and water (1225.6±20.6 MU) extracts (400 estradiol equivalents). Extracts showed antiestrogenic properties by reducing the transcriptional activity induced by estradiol in transgenic yeast. The highest antiestrogenic activity was detected in S2 methanol extract and S3 water extract, which inhibited estradiol activity by 76% and 64%, respectively. After GI digestion, S1, S2 and S3 extracts showed significantly higher estrogenic and antiestrogenic activities as 'serum-available' than 'colon-available' samples and S4 and S5 extracts showed significantly higher activities as 'colon-available' than 'serum-available' samples. Conclusion:All dietary supplements revealed estrogenic and antiestrogenic activities. The GI digestion demonstrated the availability of phytoestrogens for absorption in the blood stream. Supplements containing soy isoflavones and alfalfa ingredients had the highest estrogenic activities and could be more effective than supplements with complex plant formulation in alleviating menopausal symptoms and treating osteoporosis. The transgenic yeast assays proved to be a powerful tool for assessing the in vitro estrogenic and antiestrogenic activities of dietary supplements.

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“…For example, a trial of 72 women randomly divided between placebo and 40 mg dried red clover daily for 12 weeks showed a signiicant reduction in menopausal symptoms as measured by the Menopause Rating Scale [50]. In contrast, other clinical trials have not shown a signiicant diference from placebo, particularly for hot lashes relief [5].…”

Section: Clinical Studiesmentioning

confidence: 99%

Use of Phytoestrogens for the Treatment of Psychiatric Symptoms Associated with Menopause Transition

Estrada‐Camarena¹,

López‐Rubalcava²,

Sustaita³

et al. 2017

A Multidisciplinary Look at Menopause

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Menopause transition is recognized as a vulnerable period in women life to develop or aggravate symptoms of psychiatric disorders. Several treatments including antidepressants and hormonal restitution with estrogens have been suggested to ameliorate the symptoms. Also, in this period of life is frequent the use of other drugs to treat is also frequent the use of other drugs to treat comorbid pathologies that might even increase the risk of drug-drug interactions. Literature reports that some phytochemicals with estrogenic activity have beneicial efects during menopausal transition without collateral events. This chapter shows evidence about the use of phytoestrogens as an alternative therapy for the treatment of some psychiatric symptoms associated with the menopausal transition. Data derived from preclinical research related to the use of classical phytoestrogens (isolavones), considering the beneicial efects, as well as adverse events, are discussed. Also, the use of polyphenols and organosulfurate compounds as an alternative for the treatment of anxiety-and depressive-like behavior as well as ibromyalgia is included. A narrative review was conducted using bibliography reporting the use of isolavones (genistein, daidzein, equol), coumestans or lignans for the reduction of depressive-like or anxiety-like behavior. Furthermore, it is described if the use of this compounds impact in other signs of menopause, i.e. vasomotor and osteoporosis. In addition, due to the high frequency of comorbid pathologies as diabetes mellitus, dyslipidemia or metabolic syndrome with psychiatric disorders, the use of these phytochemicals is discussed.

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Effectiveness of red clover in alleviating menopausal symptoms: a 12-week randomized, controlled trial

Abstract: These results indicated that, compared to placebo, dried leaves of red clover were more effective in reducing the severity of menopausal symptoms in postmenopausal women.

Cited by 35 publications

References 40 publications

Trifoliumspecies – the latest findings on chemical profile, ethnomedicinal use and pharmacological properties

Trifoliumspecies – the latest findings on chemical profile, ethnomedicinal use and pharmacological properties

Estrogenic and Antiestrogenic Activities of Commercial Dietary Supplements Containing Herbal Ingredients and Isoflavones

Use of Phytoestrogens for the Treatment of Psychiatric Symptoms Associated with Menopause Transition

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