Effectiveness of Lippia sidoides Cham. (Verbenaceae) essential oil in inhibiting the growth of Staphylococcus aureus strains isolated from clinical material

Oliveira, Fillipe Pereira de; Lima, Edeltrudes de Oliveira; Júnior, José Pinto de Siqueira; Souza, Evandro Leite de; Santos, Bernadete; Barreto, Humberto Medeiros

doi:10.1590/s0102-695x2006000400013

Cited by 39 publications

(32 citation statements)

References 44 publications

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“…Lippia sidoides (Cham.) essential oil was diluted in the emulsifying agent DMSO (dimethyl sulfoxide) to obtain the concentrations 150, 75, 37.5, 18.75 and 9.37 L essential oil mL -1 (Oliveira et al, 2006).…”

Section: Methodsmentioning

confidence: 99%

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Antimicrobial activity of Lippia sidoides Cham. (Verbenaceae) essential oil against Staphylococcus aureus and Escherichia coli

Castro

Ribeiro

Diniz

et al. 2011

Rev. bras. plantas med.

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ABSTRACT:The antibacterial effect of Lippia sidoides (rosemary pepper) essential oil was tested against the bacteria Staphylococcus aureus and Escherichia coli isolated from homemade Minas cheese produced in Brazil. The Minimum Inhibitory Concentration (MIC) determined in the Dilution Test was 13 L oil mL -1 for both bacteria, which characterizes inhibitory action in broth for a 24-hour interaction period. The Minimum Bactericidal Concentration (MBC) determined in the Suspension Test, with one minute of contact, was 25 L oil mL -1 for both tested bacteria, obtaining at this concentration a bactericidal effect of 99.9% on the viable bacterial cells from each sample. Results demonstrated the bacterial activity of Lippia sidoides essential oil against S. aureus and E. coli, suggesting its use as an antibacterial agent in foods.

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Section: Methodsmentioning

confidence: 99%

“…The disk diffusion technique (Oliveira et al, 2006) was used to determine the sensitivity of bacteria tested for MIC and MBC of Lippia sidoides essential oil. Sterile filter paper disks measuring 6mm diameter, saturated with 20 L crude oil and oil in each of the dilutions, were prepared and dried in a greenhouse.…”

Section: Methodsmentioning

confidence: 99%

Antimicrobial activity of Lippia sidoides Cham. (Verbenaceae) essential oil against Staphylococcus aureus and Escherichia coli

Castro

Ribeiro

Diniz

et al. 2011

Rev. bras. plantas med.

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“…is a perennial bushy plant native to the Caatinga, which is rich in aromatic essential oils. The medicinal properties of L. sidoides essential oil include antifungal (Fontenelle et al, 2007), antibacterial (Oliveira et al, 2006;Lobo et al, 2011), anti-helminthic (Camurça-Vasconcelos et al, 2008, larvicidal, and acaricidal activities (Carvalho et al, 2003;Cavalcanti et al, 2010). Some of these biological properties are attributed to the presence of thymol and carvacrol in its essential oil (Carvalho et al, 2003;Botelho et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Leishmanicidal activity of carvacrol-rich essential oil from Lippia sidoides Cham

et al. 2012

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Leishamaniasis is a disease that aff ects more than 2 million people worldwide, whose causative agent is Leishmania spp. The current therapy for leishmaniasis is far from satisfactory. All available drugs, including pentavalent antimony, require parenteral administration and are potentially toxic. Moreover, an increase in clinical resistance to these drugs has been reported. In this scenario, plant essential oils used traditionally in folk medicine are emerging as alternative sources for chemotherapeutic compounds. In this study, in vitro leishmanicidal eff ects of a thymol-and a carvacrol-rich essential oil from leaves of Lippia sidoides Cham. were investigated. The essential oils were extracted and their constituents were characterized by gas chromatography coupled to mass spectrometry (GC/MS). Both essential oils showed signifi cant activity against promastigote forms of Leishmania chagasi. However, we found that carvacrol-rich essential oil was more eff ective, with IC 50 /72 h of 54.8 μg/mL compared to 74.1 μg/mL for thymol-rich oil. Carvacrol also showed lower IC 50 than thymol. Our data suggest that L. sidoides essential oils are indeed promising sources of leishmanicidal compounds.

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“…In this perspective, recent studies have reported a series of biological properties of essential oil, such as insecticidal activity on larvae of Aedes aegypti L. (CAVALCANTI et al, 2004); acaricidal activity aginst Tetranychus urticae bactericidal effect against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli (BERTINI et al, 2005;OLIVEIRA et al, 2006); Streptococcus spp. and Candida albicans (BOTELHO et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and fumigant effect of essentialoil of Lippia sidoides Cham. and monoterpenes against Tenebrio molitor (L.) (coleoptera: tenebrionidae)

et al. 2011

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The chemical composition of Lippia sidoides essential oils obtained by hydrodistillation was characterized and quantified by GC/MS and their insecticidal activity by fumigation test was assayed against Tenebrio molitor. Moreover, the toxicity of monoterpenes carvacrol, 1,8-cineol and thymol were also evaluated when applied alone or in binary (1:1) or tertiary (1:1:1) mixture. The essential oil of L. sidoides has as major constituents carvacrol (31.68%), -cymene (19.58%), 1,8-cineole (9.26%) and -terpinene (9.21%), from a 21 compounds identified, being 92.53% of total. Both compounds have insecticidal activity against T. molitor, being the degree of toxicity of carvacrol > 1,8-cineole > L. sidoides essential oil > thymol, and its respectively LC 50 at 24h were 5.53; 5.71; 8.04 and 14.71 µL/L air. When the different mixture of carvacrol, 1,8-cineole and thymol was assayed against T. molitor, the synergism among them was observed. For the mixture of carvacrol:1,8-cineole LC 50 was 5.34 µL/L air; carvacrol:thymol 7.67 µL/L air; 1,8-cineole:thymol 7.51 µL/L air and carvacrol:1,8-cineole:thymol 6.34 µL/L air. Mainly, the monoterpene thymol had a synergic effect, which increased the toxicity of carvacrol and 1,8-cineole, both in binary mixture like carvacrol:thymol and 1,8-cineole:thymol.Index terms: "Alecrim pepper", mealworm, natural compound, toxicity, synergism. RESUMOA composição química do óleo essencial de Lippia sidoides obtido por hidrodestilação foi caracterizada e quantificada por GC/MS, bem como sua atividade inseticida por teste de fumigação foi avaliada sobre Tenebrio molitor. Além disso, a toxicidade dos monoterpenos carvacrol, 1,8-cineol e timol, também foi avaliada quando esses compostos foram aplicados isoladamente, ou em misturas binárias (1:1), ou terciárias (1:1:1). O óleo essencial de L. sidoides tem como principais constituintes o carvacrol (31,68%), ñ-cimeno (19,58%), 1,8-cineol (9,26%) e -terpineno (9,21%), em 21 compostos identificados, sendo 92,53% do total. Termos para indexação: Alecrim pimenta, bicho-da-farinha, produto natural, toxicidade, sinergismo.

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Effectiveness of Lippia sidoides Cham. (Verbenaceae) essential oil in inhibiting the growth of Staphylococcus aureus strains isolated from clinical material

Cited by 39 publications

References 44 publications

Antimicrobial activity of Lippia sidoides Cham. (Verbenaceae) essential oil against Staphylococcus aureus and Escherichia coli

Antimicrobial activity of Lippia sidoides Cham. (Verbenaceae) essential oil against Staphylococcus aureus and Escherichia coli

Leishmanicidal activity of carvacrol-rich essential oil from Lippia sidoides Cham

Chemical composition and fumigant effect of essentialoil of Lippia sidoides Cham. and monoterpenes against Tenebrio molitor (L.) (coleoptera: tenebrionidae)

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