Effectiveness of Fibrin Adhesive in Facial Nerve Anastomosis in Dogs Compared With Standard Microsuturing Technique

Attar, Bijan Movahedian; Zalzali, Haidar; Razavi, Mohammad; Ghoreishian, Mehdi; Rezaei, Majid

doi:10.1016/j.joms.2011.11.007

Cited by 16 publications

(16 citation statements)

References 36 publications

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“…The fastest nerve fibers have larger diameters and are myelinated [40]. The fact that the CG and the experimental groups had statistically similar results in the cited measures showed that the two repair techniques analyzed are efficient, with satisfactory results in relation to the degree of maturation of fibers [13].…”

Section: Discussionmentioning

confidence: 99%

“…However, despite the end-to-end epineural suture technique being a widely used method in neurological injuries of neurotmesis lesions of minor extent, it requires microsurgery techniques, as well as excessive manipulation of the tissues for the approximation of the stumps [13,14]. The fibrin sealant is being used in the recovery of peripheral nerve injuries, with the purpose of minimizing the disadvantages of the epineural suture technique [15].…”

Section: Introductionmentioning

confidence: 99%

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The new heterologous fibrin sealant in combination with low-level laser therapy (LLLT) in the repair of the buccal branch of the facial nerve

et al. 2016

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This study aimed to evaluate the effects of low-level laser therapy (LLLT) in the repair of the buccal branch of the facial nerve with two surgical techniques: end-to-end epineural suture and coaptation with heterologous fibrin sealant. Forty-two male Wistar rats were randomly divided into five groups: control group (CG) in which the buccal branch of the facial nerve was collected without injury; (2) experimental group with suture (EGS) and experimental group with fibrin (EGF): The buccal branch of the facial nerve was transected on both sides of the face. End-to-end suture was performed on the right side and fibrin sealant on the left side; (3) Experimental group with suture and laser (EGSL) and experimental group with fibrin and laser (EGFL). All animals underwent the same surgical procedures in the EGS and EGF groups, in combination with the application of LLLT (wavelength of 830 nm, 30 mW optical power output of potency, and energy density of 6 J/cm(2)). The animals of the five groups were euthanized at 5 weeks post-surgery and 10 weeks post-surgery. Axonal sprouting was observed in the distal stump of the facial nerve in all experimental groups. The observed morphology was similar to the fibers of the control group, with a predominance of myelinated fibers. In the final period of the experiment, the EGSL presented the closest results to the CG, in all variables measured, except in the axon area. Both surgical techniques analyzed were effective in the treatment of peripheral nerve injuries, where the use of fibrin sealant allowed the manipulation of the nerve stumps without trauma. LLLT exhibited satisfactory results on facial nerve regeneration, being therefore a useful technique to stimulate axonal regeneration process.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The new heterologous fibrin sealant in combination with low-level laser therapy (LLLT) in the repair of the buccal branch of the facial nerve

et al. 2016

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“…A case report used fibrin sealant to help seal a dural CSF leak causing a pseudomeningocele following lumbar disc surgery with a subsequent complete resolution of a concomitant abducens nerve palsy and diplopia [228]. Several papers address the role of fibrin sealant in nerve repair including an end to side nerve repair in rats [229] and a facial nerve repair in dogs [230] failing to find a fibrin sealant benefit and a favorable report of using a fibrin conduit for mesenchymal stem cells particularly in the presence of cylcosporine to enhance regeneration following peripheral nerve injury in rats [231]. Laser soldering in pigs [232] was described as superior to fibrin sealant for dural reconstruction as having higher burst pressure strength (98.00 ± 21.41 versus 70.80 ± 15.09 mmHg, resp.…”

Section: Less Frequently Published Clinical Applications Of Fibrinmentioning

confidence: 99%

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

2014

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Background. Fibrin sealant became the first modern era material approved as a hemostat in the United States in 1998. It is the only agent presently approved as a hemostat, sealant, and adhesive by the Food and Drug Administration (FDA). The product is now supplied as patches in addition to the original liquid formulations. Both laboratory and clinical uses of fibrin sealant continue to grow. The new literature on this material also continues to proliferate rapidly (approximately 200 papers/year). Methods. An overview of current fibrin sealant products and their approved uses and a comprehensive PubMed based review of the recent literature (February 2012, through March 2013) on the laboratory and clinical use of fibrin sealant are provided. Product information is organized into sections based on a classification system for commercially available materials. Publications are presented in sections based on both laboratory research and clinical topics are listed in order of decreasing frequency. Results. Fibrin sealant remains useful hemostat, sealant, and adhesive. New formulations and applications continue to be developed. Conclusions. This agent remains clinically important with the recent introduction of new commercially available products. Fibrin sealant has multiple new uses that should result in further improvements in patient care.

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“…43 The success of this technique has been researched and replicated by other authors. 3,7,39,49 Suturing is reserved only for extradural coaptation.…”

Section: Technique Of Reconstructionmentioning

confidence: 99%

Surgical technique and results of cable graft interpositioning of the facial nerve in lateral skull base surgeries: experience with 213 consecutive cases

Prasad¹,

Karthikeyan²,

Piccirillo³

et al. 2018

Journal of Neurosurgery

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OBJECTIVE The aim in this study was to review the technique and outcomes of cable graft interpositioning of the facial nerve (FN) in lateral skull base surgeries. METHODS The authors retrospectively evaluated data from patients who had undergone cable graft interpositioning after nerve sacrifice during skull base tumor removal between June 1987 and May 2015. All patients had undergone lateral skull base approaches to remove tumors at a quaternary referral center in Italy. Facial nerve function was evaluated before and after surgery using the House-Brackmann (HB) grading system. RESULTS Two hundred thirteen patients were eligible for study. The mean follow-up was 44.3 months. The most common pathology was vestibular schwannoma (83 cases [39%]), followed by FN tumor (67 cases [31%]). Facial nerve tumors had the highest incidence of nerve interruption (67 [66%] of 102 cases). Preoperative FN function was normal (HB Grade I) in 105 patients (49.3%) and mild (HB Grade II) in 19 (8.9%). At the last postoperative follow-up, 108 (50.7%) of the 213 patients had recovered to Grade III nerve function. Preoperative HB grading of the FN was found to have a significant effect on outcome (p = 0.002). CONCLUSIONS Cable graft interpositioning is a convenient and well-accepted procedure for immediate restoration of the FN. The study results, over a large number of patients, showed that the stitch-less fibrin glue-aided coaptation technique yields good results. The best possible postoperative result achieved was an HB Grade III. The chances of a good postoperative result increase when FN function is normal preoperatively. Slow-growing tumors of the cerebellopontine angle had a favorable outcome after grafting.

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Effectiveness of Fibrin Adhesive in Facial Nerve Anastomosis in Dogs Compared With Standard Microsuturing Technique

Cited by 16 publications

References 36 publications

The new heterologous fibrin sealant in combination with low-level laser therapy (LLLT) in the repair of the buccal branch of the facial nerve

The new heterologous fibrin sealant in combination with low-level laser therapy (LLLT) in the repair of the buccal branch of the facial nerve

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

Surgical technique and results of cable graft interpositioning of the facial nerve in lateral skull base surgeries: experience with 213 consecutive cases

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