Effectiveness of Blue light photobiomodulation therapy in the treatment of chronic wounds. Results of the Blue Light for Ulcer Reduction (B.L.U.R.) Study

Fraccalvieri, Marco; Amadeo, Giuseppe; Bortolotti, P; Ciliberti, Marino; Garrubba, Angela; Mosti, Giovanni; Bianco, Salvatore Lo; Mangia, Antongiulio; Massa, M.; Hartwig, Valentina; Salvo, Pietro; Ricci, E

doi:10.23736/s2784-8671.21.07067-5

Cited by 16 publications

(15 citation statements)

References 30 publications

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“…As the quest for a light therapy offering more attractive risk-benefit ratio continues, the lower energy blue light photons, spanning the 400-495 nm range, being the "nearest neighbor" of UVR (i.e., UVA) has become the focus of attention. By now, a significant increase in the clinical use of the blue light phototherapy has been reported [8,39,48,49] including PDT of AK [19], treatment of neonatal jaundice [50], acne [19,49,[58][59][60][61][62][63][64][65], psoriasis vulgaris [48,[67][68][69][70]101], eczema [48,71,93], alopecia [51], blood pressure reduction [52], stimulation of endorphin release [53], chronic wound healing [55][56][57], and many more, where the efficacy and thus the benefits of blue light therapies is evidenced from numerous clinical studies.…”

Section: Discussionmentioning

confidence: 99%

“…In an attempt to find a "safer" yet effective therapy, the last decade has witnessed a significant increase in the use of the blue light (400-495 nm) within the parameter window (irradiance and exposure time), which induces photobiological effects [8,39,48,49]. Applications include its use as an exogenous photosynthesizer in the treatment of actinic keratosis (AK) during photodynamic therapy (PDT) [19] and on endogenous molecular targets in neonatal jaundice [50], acne [19,49], psoriasis vulgaris [48], eczema [48] alopecia [51], blood pressure reduction [52], stimulation of endorphin release [53], pain relief [54], chronic wounds [55][56][57], and so forth.…”

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confidence: 99%

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Highlighting nuances of blue light phototherapy: Mechanisms and safety considerations

Uzunbajakava

Tobin

Botchkareva

et al. 2022

Journal of Biophotonics

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The efficacy of blue light therapy in dermatology relies on numerous clinical studies. The safety remains a topic of controversy, where potentially deleterious effects were derived from in vitro rather than in vivo experiments. The objectives of this work were (1) to highlight the nuances behind “colors” of blue light, light propagation in tissue and the plurality of modes of action; and (2) to rigorously analyze studies on humans reporting both clinical and histological data from skin biopsies with focus on DNA damage, proliferation, apoptosis, oxidative stress, impact on collagen, elastin, immune cells, and pigmentation. We conclude that blue light therapy is safe for human skin. It induces intriguing skin pigmentation, in part mediated by photoreceptor Opsin‐3, which might have a photoprotective effect against ultraviolet irradiation. Future research needs to unravel photochemical reactions and the most effective and safe parameters of blue light in dermatology.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Highlighting nuances of blue light phototherapy: Mechanisms and safety considerations

Uzunbajakava

Tobin

Botchkareva

et al. 2022

Journal of Biophotonics

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“…The same device was used in a study for the treatment of chronic wounds. Here, blue light treatment, in addition to standard care, accelerates the re-epithelialization rate of chronic wounds [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Low-Dose Blue Light (420 nm) Reduces Metabolic Activity and Inhibits Proliferation of Human Dermal Fibroblasts

Brüning

Schiefer

Fuchs

et al. 2023

Life

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Hypertrophic scarring in burn wounds is caused by overactive fibroblasts and myofibroblasts. Blue light reveals wavelength- and dose-dependent antibacterial and antiproliferative effects and may serve as a therapeutic option against wound infection and fibrotic conditions. Therefore, we evaluated in this study the effects of single and multiple irradiations with blue light at 420 nm (BL420) on the intracellular ATP concentration, and on the viability and proliferation of the human skin fibroblast (HDFs). In addition, possible BL420-induced effects on the catalase expression and differentiation were assessed by immunocytochemical staining and western blot analyses. Furthermore, we used RNA-seq analyses to identify BL420-affected genes. We found that BL420 induced toxicity in HDFs (up to 83%; 180 J/cm2). A low dose of 20 J/cm2 reduced the ATP concentration by ~50%. Multiple irradiations (4 × 20 J/cm2) inhibited proliferation without visible toxicity and reduced catalase protein expression by ~37% without affecting differentiation. The expression of about 300 genes was significantly altered. Many downregulated genes have functions in cell division/mitosis. BL420 can strongly influence the fibroblast physiology and has potential in wound therapy. However, it is important to consider the possible toxic and antiproliferative effects, which could potentially lead to impaired wound healing and reduced scar breaking strength.

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“…In the current study, a blue light ranging from 410 to 430 nm was used. Its beneficial effects on the wound healing process were clinically demonstrated [ 28 , 29 , 30 , 31 ]. Our previous experiments studied the effects followed by the blue-LED-light treatment after 24 h from irradiation [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Blue-LED-Light Photobiomodulation of Inflammatory Responses and New Tissue Formation in Mouse-Skin Wounds

Magni

Tatini

Siena

et al. 2022

Life

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Background: Recent studies evidence that blue-LED-light irradiation can modulate cell responses in the wound healing process within 24 hours from treatment. This study aims to investigate blue-light (410–430 nm) photobiomodulation used in a murine wound model within six days post-treatment. Methods: A superficial wound was made in 30 CD1 male mice. The injuries were treated with a blue LED light (20.6 J/cm2), and biopsies were collected at 24, 72, and 144 hours. Histology, fluorescence analysis, and advanced microscopy techniques were used. Results: We can observe an increase in the cellular infiltrate response, and in mast-cell density and their degranulation index correlated to the expression of the major histocompatibility complex after 24 hours. Furthermore, after six days, the vessel density increases with the expression of the platelet-derived growth factor in the mast cells. Finally, collagen deposition and morphology in the treated wounds appear more similar to unwounded skin. Conclusions: Blue-light photobiomodulation stimulates several cellular processes that are finely coordinated by mast cells, leading to more rapid wound healing and a better-recovered skin morphology.

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Effectiveness of Blue light photobiomodulation therapy in the treatment of chronic wounds. Results of the Blue Light for Ulcer Reduction (B.L.U.R.) Study

Cited by 16 publications

References 30 publications

Highlighting nuances of blue light phototherapy: Mechanisms and safety considerations

Highlighting nuances of blue light phototherapy: Mechanisms and safety considerations

Low-Dose Blue Light (420 nm) Reduces Metabolic Activity and Inhibits Proliferation of Human Dermal Fibroblasts

Blue-LED-Light Photobiomodulation of Inflammatory Responses and New Tissue Formation in Mouse-Skin Wounds

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