Effect on Oximetry of Dyes Used for Sentinel Lymph Node Biopsy

Piñero, Antonio; Illana, Julián; García-Palenciano, Carlos; Cañizares, Francisco Seva; Canteras, Manuel; Cañadillas, Victoria; Durán, Eugenia; Parrilla, Pascual

doi:10.1001/archsurg.139.11.1204

Cited by 33 publications

(21 citation statements)

References 27 publications

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“…Our findings were comparable to Pin) ero' s study, (14) which revealed no significant changes in oxy-…”

Section: Pulse Oximetry Is the Standard Methods For Non-inva-supporting

confidence: 91%

“…Methylene blue theoretically is retained less and cleared more from the blood stream through the kidneys than isosulfan blue. (9,14,22) Scheller et al (9) reported that the peripheral pulse oximetry was transiently lowered among healthy volunteers who were injected intravenously with 5 mL of 1% methylene blue.…”

Section: Pulse Oximetry Is the Standard Methods For Non-inva-mentioning

confidence: 99%

“…Pin) ero et al (14) compared the effects of methylene blue and isosulfan blue on oxygen saturation in a randomized, prospective study. Both dyes interfered with the peripheral saturation reading, but only isosulfan blue showed significant differences.…”

Section: Pulse Oximetry Is the Standard Methods For Non-inva-mentioning

confidence: 99%

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Intraparenchymal Methylene Blue Injection for Sentinel Lymph Node Biopsy in Breast Cancer Patients does not Interfere with the Pulse Oximetry Readings

et al. 2009

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“…Our findings were comparable to Pin) ero' s study, (14) which revealed no significant changes in oxy-…”

Section: Pulse Oximetry Is the Standard Methods For Non-inva-supporting

confidence: 91%

Section: Pulse Oximetry Is the Standard Methods For Non-inva-mentioning

confidence: 99%

See 1 more Smart Citation

Intraparenchymal Methylene Blue Injection for Sentinel Lymph Node Biopsy in Breast Cancer Patients does not Interfere with the Pulse Oximetry Readings

et al. 2009

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“…13 Furthermore, compared to the other dyes, methylene blue interferes less with oximetry. 24 Nevertheless, a case has been reported in the literature of a pulmonary edema possibly related to the use of methylene blue for the detection of the sentinel lymph node. 25 Another advantage of methylene blue is the possibility of being able to use it during pregnancy, which is not the case with the other dyes.…”

Section: Discussionmentioning

confidence: 99%

A prospective randomized trial comparing patent blue and methylene blue for the detection of the sentinel lymph node in breast cancer patients

Paulinelli

Freitas‐Junior

Rahal

et al. 2017

Rev. Assoc. Med. Bras.

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Introduction:Methylene blue is more widely available and less expensive than patent blue, with an apparently lower risk of anaphylaxis. Objective: The two dyes were compared regarding detection of the sentinel lymph node (SLN). Method: A prospective, randomized trial involved 142 patients with invasive breast carcinoma. Sixty-nine (49.3%) assigned to patent blue (group A) and 71 (50.70%) to methylene blue (group B). Thirty-five patients (25.0%) were clinical stage III or IV; 55 (38.7%) had axillary lymph nodes affected; and 69 (49.3%) underwent neoadjuvant chemotherapy. Two patients were excluded because the dye type was not recorded. Results: Patients and tumor characteristics were similar in both groups. SLNs were identified in 47 women (68.1%) in group A and 43 (60.6%) in group B (p=0.35). SLNs were affected in 22 cases (51.2%) in group A and 21 (48.8%) in group B (p=0.62). The SLN was the only node affected in 12 cases (54.5%) in group A and six (33.3%) in group B (p=0.18). The time and degree of difficulty involved in identifying the SLN were similar in both groups. There were no complications or allergies. Conclusion: Methylene blue performed as well as patent blue in identifying the SLN in breast cancer patients.

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“…(12,13) There is also a controlled trial about the effects of methylene blue versus isosulfan blue usage in SNLB. (14) Pinero et al (14) compared isosulfan blue with methylene blue in 32 patients who were undergoing SLNB and obtained arterial blood samples for blood gas analysis but could not demonstrate any significant changes in blood gas analysis. On the other hand, the investigators did not state whether methemoglobin levels also included in this analysis or not.…”

Section: Discussionmentioning

confidence: 99%

Methemoglobinemia Due to Isosulfan Blue Used for Sentinel Lymph Node Mapping

Sınıkoglu¹,

Yeter²,

Gümüş³

et al. 2012

JTAICS

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SUMMARYA 62 year-old woman, weighing 60 kg with ASA I was scheduled for sentinel lymph node biopsy. Her pulse oximetry values rapidly declined to a nadir of 88 % 30 min after subcutaneous injection of isosulfan blue. Arterial blood gas analysis revealed methemoglobinemia ([MetHb] = 5.2 %). Following 3 L/min O2 administration via nasal CPAP mask and 2x500 mg iv ascorbic acid treatment, methemoglobin levels dropped to 1.7 % after 15 hours. Although abnormal pulse oximetry has already been reported in association with isosulfan blue administration , methemoglobinemia due to isosulfan blue was reported just in a few cases. Key words: Methemoglobinemia, isosulfan ÖZET Sentinel Lenf Nodu İşaretlemesi İçin Kullanılan İsosulfan Mavisine Bağlı Methemoglobinemi62 yaşında, 60 kg, ASA I kadın hastaya biyopsi sırasında sentinel lenf nodunu tespit etmek için subkutan isosulfan verildi. İsosulfan mavisi verildikten 30 dk. sonra pulse oksimetre oksijen satürasyonu değerleri hızla % 88'e kadar düştü. Arter kan gazı analizinde % 5.2 methemoglobinemi bulundu. Nasal CPAP maskesiyle 3 L/m O 2 ve 2x500 mg iv askorbik asit tedavisiyle methemoglobinemi 15 saat sonra % 1.7'ye indi. İsosulfan mavisine bağlı anormal pulse oksimetre değerleri daha önce yayınlanmış olmasına rağmen, isosulfan mavisine bağlı methemoglobinemi sadece birkaç olguda bildirilmiştir.

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Effect on Oximetry of Dyes Used for Sentinel Lymph Node Biopsy

Abstract: Hypothesis: There are differences between readings of peripheral blood oxygen saturation when the effect on saturation values of methylene blue is compared with that of isosulfan blue when used in sentinel lymph node biopsy in patients with breast cancer.

Cited by 33 publications

References 27 publications

Intraparenchymal Methylene Blue Injection for Sentinel Lymph Node Biopsy in Breast Cancer Patients does not Interfere with the Pulse Oximetry Readings

Intraparenchymal Methylene Blue Injection for Sentinel Lymph Node Biopsy in Breast Cancer Patients does not Interfere with the Pulse Oximetry Readings

A prospective randomized trial comparing patent blue and methylene blue for the detection of the sentinel lymph node in breast cancer patients

Methemoglobinemia Due to Isosulfan Blue Used for Sentinel Lymph Node Mapping

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