Effect on fetal mouse development of exposure to MR imaging and gadopentetate dimeglumine

Rofsky, Neil M.; Pizzarello, Donald J.; Weinreb, Jeffrey C.; Ambrosino, M. M.; Rosenberg, Carl

doi:10.1002/jmri.1880040611

Cited by 52 publications

(21 citation statements)

References 14 publications

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“…Neither intraperitoneal gadopentetate dimeglumine plus magnetic resonance nor intraperitoneal gadopentetate dimeglumine alone had any detectable effect on the development of mice [18]. No teratogenic effects or effects on postnatal development were seen following gadopentate dimeglumine, gadoteridol, gadobenate dimeglumine, or gadoversetamide use in animals [18][19][20][21].…”

Section: Mutagenicity and Teratogenicity Of Contrast Mediamentioning

confidence: 57%

The use of iodinated and gadolinium contrast media during pregnancy and lactation

Webb

Thomsen

Morcos³

2004

Eur Radiol

512

180

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The use of iodinated or gadolinium-based contrast media in pregnant or lactating women often causes concerns in the radiology department because of the principle of not exposing a fetus or neonate to any drugs. Because of the uncertainty about the use of contrast media during pregnancy and lactation, the Contrast Media Safety Committee of the European Society of Urogenital Radiology decided to review the literature and draw up guidelines. An extensive literature search was carried out and summarized in a report. Based on the limited information available, simple guidelines have been drawn up. The report and guidelines were discussed at the 11th European Symposium on Urogenital Radiology in Santiago de Compostela, Spain. Mutagenic and teratogenic effects have not been described after administration of gadolinium or iodinated contrast media. Free iodide in radiographic contrast medium given to the mother has the potential to depress fetal/neonatal thyroid function. Neonatal thyroid function should be checked during the 1st week if iodinated contrast media have been given during pregnancy. No effect on the fetus has been seen after gadolinium contrast media. Only tiny amounts of iodinated or gadolinium-based contrast medium given to a lactating mother reach the milk, and only a minute proportion entering the baby's gut is absorbed. The very small potential risk associated with absorption of contrast medium may be considered insufficient to warrant stopping breast-feeding for 24 h following either iodinated or gadolinium contrast agents.

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Section: Mutagenicity and Teratogenicity Of Contrast Mediamentioning

confidence: 57%

The use of iodinated and gadolinium contrast media during pregnancy and lactation

Webb

Thomsen

Morcos³

2004

Eur Radiol

512

180

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“…Animal studies have not documented teratogenicity or postnatal development effects after the administration of gadopentetate dimeglumine, gadoteridol, gadobenate dimeglumine or gadoversetamide [76][77][78][79]. There is, however, a reservation arising from the scientific observation that once excreted by foetal kidneys, the chelate of gadolinium remains in the amniotic fluid and is ingested through the gastrointestinal tube and re-excreted numerous times: the persistence of the molecule in a "closed" compartment such as the fetoplacental system could lead to the dissociation of the gadolinium ion (which is toxic per se) from the chelate, thus giving rise to a risk of toxicity that is still not fully known.…”

Section: Noise-induced Damagementioning

confidence: 97%

Patient safety issues in magnetic resonance imaging: state of the art

2007

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The presence of a static magnetic field (Bo), a radiofrequency field (RF), a dynamic gradient which varies in time and loud noises during an MR examination could increase patient risk. Specifically, a magnetic field could interfere with ferromagnetic material leading to one of the following five dangerous interactions: 1) projectile effect, 2) twisting, 3) burning, 4) artefacts and 5) device malfunction. The projectile effect is when an object is attracted by the magnet with the risk, as reported in literature, of hitting the patient, operators and/or the instrument. Objects which typically can undergo this effect are oxygen and helium cylinders, IV stands, cleaning trolleys, chairs, lamp holders, scissors, forceps, clampers, traction weights, monitoring instruments, and especially metallic splinters within the patient. Twisting (torsion) typically occurs with cerebral vascular clamps and cochlear implants. If parts of implants are involved a malfunction may result. Burns can be caused when electrically conductive material is introduced within the magnet, for example, ECG electrodes, monitoring cables and coils which are in contact with the patient's skin, as well as tattoos and eye-liners that contain iron-oxides. Artefacts can be induced by RF emission of implanted devices which can be mistaken for noise of the receiving coil. Implanted devices can induce signal voids which mask or simulate pathologies. Electrical or mechanical malfunction of implanted devices includes pacemakers which can stimulate inappropriately or at an elevated frequency yielding a distorted ECG with altered T-waves. The risk for patients can be reduced by specific educational programs within individual radiology departments which include other specializations and external referring physicians with the aim of developing a standardized safety protocol.

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“…In customary dosages of 0.1-0.3 mmol/kg body weight, the likelihood of fetal injury has been estimated to be low [63]. In animal studies where gadolinium was administrated to pregnant animals in different dosages, no adverse effects on the fetuses were observed [64]. Only rabbits receiving 1×-12.5× human dosages for 5-12 days of Gd-DTPA compounds were reported to have retarded development, increased locomotor activity, and skeletal and visceral abnormalities [65].…”

Section: Normal Contrast-enhancementmentioning

confidence: 99%

Investigation of normal organ development with fetal MRI

Prayer

Brugger

2007

Eur Radiol

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The understanding of the presentation of normal organ development on fetal MRI forms the basis for recognition of pathological states. During the second and third trimesters, maturational processes include changes in size, shape and signal intensities of organs. Visualization of these developmental processes requires tailored MR protocols. Further prerequisites for recognition of normal maturational states are unequivocal intrauterine orientation with respect to left and right body halves, fetal proportions, and knowledge about the MR presentation of extrafetal/intrauterine organs. Emphasis is laid on the demonstration of normal MR appearance of organs that are frequently involved in malformation syndromes. In addition, examples of time-dependent contrast enhancement of intrauterine structures are given.

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Effect on fetal mouse development of exposure to MR imaging and gadopentetate dimeglumine

Cited by 52 publications

References 14 publications

The use of iodinated and gadolinium contrast media during pregnancy and lactation

The use of iodinated and gadolinium contrast media during pregnancy and lactation

Patient safety issues in magnetic resonance imaging: state of the art

Investigation of normal organ development with fetal MRI

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