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A n outbreak of coronavirus disease 2019 (COVID-19) began in Wuhan, China, in December 2019 and has rapidly spread around the world to become a pandemic (1). Italy was the second epicenter of the spread of the disease, and at the time of writing has a total of 222 104 cases and 31 106 deaths (1). Several studies have described the spectrum of chest imaging features of COVID-19 (2). However, to date, only a few case reports have described COVID-19-associated neurologic imaging findings (3-8). The purpose of our study was to systematically characterize neurologic symptoms and neuroimaging features in hospitalized patients with COVID-19 from multiple institutions in Italy.

Many coronavirus disease 2019 (Covid-19) survivors show symptoms months after acute illness. The aim of this work is to describe the clinical evolution of Covid-19, one year after discharge. We performed a prospective cohort study on 238 patients previously hospitalized for Covid-19 pneumonia in 2020 who already underwent clinical follow-up 4 months post-Covid-19. 200 consented to participate to a 12-months clinical assessment, including: pulmonary function tests with diffusing lung capacity for carbon monoxide (DLCO); post-traumatic stress (PTS) symptoms evaluation by the Impact of Event Scale (IES); motor function evaluation (by Short Physical Performance Battery and 2 min walking test); chest Computed Tomography (CT). After 366 [363–369] days, 79 patients (39.5%) reported at least one symptom. A DLCO < 80% was observed in 96 patients (49.0%). Severe DLCO impairment (< 60%) was reported in 20 patients (10.2%), related to extent of CT scan abnormalities. Some degree of motor impairment was observed in 25.8% of subjects. 37/200 patients (18.5%) showed moderate-to-severe PTS symptoms. In the time elapsed from 4 to 12 months after hospital discharge, motor function improves, while respiratory function does not, being accompanied by evidence of lung structural damage. Symptoms remain highly prevalent one year after acute illness.

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