Effect of Zinc Supplementation on Antioxidant Status and Immune Response in Buffalo Calves

Parashuramulu, S.; Nagalakshmi, D.; Rao, D. Srinivasa; Kumar, Muneendra; Swain, Partha Sarathi

doi:10.5958/0974-181x.2015.00020.7

Cited by 25 publications

(21 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Zinc and linoleic acid increased the activity of CAT compared to the rotenone treated group. Zinc effect on Catalase activity agrees on the study of [ 35 ] who investigated the effect of zinc supplementation on antioxidant status and immune response in buffalo calves and showed that zinc supplementation increased Catalase activity. The protective effects of linoleic acid might reflect its ability to improve energy metabolism and repair damaged layers of lipids, hence suppressing the exudation of free electrons from the mitochondrial electron transport system, which is a prerequisite reaction to generate free radicals [ 29 ].…”

Section: Discussionsupporting

confidence: 83%

Zinc and linoleic acid pre-treatment attenuates biochemical and histological changes in the midbrain of rats with rotenone-induced Parkinsonism

et al. 2018

View full text Add to dashboard Cite

BackgroundStudies have suggested the supplementation of Zinc and Linoleic acid in the management of neurodegenerative disorders but none has investigated the combined effects. Little is known about the neuroprotective effects of either Zinc or Linoleic acid or their combination against development of Parkinsonism. This study was designed to investigate the neuroprotective effects of Zinc and Linoleic acid in rotenone-induced Parkinsonism in rats.MethodsThirty-six young adult female rats weighing 100–150 g divided into six groups were used. Rats were induced with Parkinsonism by subcutaneous administration of rotenone (2.5 mg/kg) once a day for seven consecutive days. The rats received dimethyl sulfoxide (DMSO)/Olive oil or rotenone dissolved in DMSO/Olive oil. Groups III and IV received Zinc (30 mg/kg) or Linoleic acid (150 µl/kg) while group V received a combination of both, 2 weeks prior to rotenone injection. Groups II and VI served as negative (rotenone group) and positive (Levodopa groups) controls respectively. Oxidative stress levels were assessed by estimating Lipid peroxidation (MDA), total antioxidant capacity, Superoxide dismutase, reduced Glutathione (GSH), glutathione peroxidase and catalase in the midbrain. Histological examination was done to assess structural changes in the midbrain.ResultsThere was a significant prevention in lipid peroxidation and decrease in the antioxidant status in intervention-treated groups as compared to the rotenone treated group. In addition, histological examination revealed that Parkinsonian rat brains exhibited neuronal damage. Cell death and reduction in neuron size induced by rotenone was prevented by treatment with zinc, linoleic acid and their combination.ConclusionThese results suggest that zinc and linoleic acid and their combination showed significant neuroprotective activity most likely due to the antioxidant effect.

show abstract

Section: Discussionsupporting

confidence: 83%

Zinc and linoleic acid pre-treatment attenuates biochemical and histological changes in the midbrain of rats with rotenone-induced Parkinsonism

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The current results of feed consumption agreed with Puchala et al [30] who reported that adding of graded levels of organic Zn (15,30,45 and 60 ppm/ kg diet) to broiler chickens did not significantly affect their feed intake when compared with the inorganic Zn. Control: group supplemented with inorganic zinc oxide; 2 Organic-Zn: group supplemented with Zn methionine; 3 Nano-ZnO: group supplemented with nano Zn-oxide; 4 Zn-mix: group supplemented with both Zn methionine and nano Zn-oxide; 5 TAG: Triglyceride; 6 HDL-C: High-density lipoprotein; 7 VLDL-C: Very low-density lipoprotein; 8 AST: Aspartate amino transferase; 9 ALT: Alanine amino transferase; 10 MDA: Malondialdehyde; 11 CuZn-SOD: Cu/Zn superoxide dismutase. a-b-c Means in a row with different superscripts were significantly different (P<0.05).…”

Section: Performance Parametersmentioning

confidence: 99%

“…This essential element has a key part in the structure and maintenance of the skeleton and acts as cofactor in many metabolic processes that necessary for hormone secretion i.e. growth and insulin hormones [1], DNA synthesis, gene expression and cellular division [2], vision photochemistry [3], enhanced the immune status [4] via energy creation, protein synthesis and cell membranes protection from endotoxins producing bacteria [5] gene transcription and RNA synthesis. Also, zinc is vital free radical's scavenger of the in-antioxidant defense system [6].…”

Section: Introductionmentioning

confidence: 99%

Effects of Different Zinc Sources on Performance, Bio Distribution of Minerals and Expression of Genes Related to Metabolism of Broiler Chickens

Ibrahim

Ali²,

El-Mandrawy³

2017

Zagazig Veterinary Journal

View full text Add to dashboard Cite

Different sources of Zinc (Zn) were compared to assess their possible effects on performance, nutrients retention, mineral distribution and some serum parameters of broiler chickens. A total of 200 one-day old Ross 308 chicks were divided into in equal four dietary treatments groups with five replicates each of ten chicks. The experimental groups were given the basal diet (inorganic ZnO), basal diet supplemented with organic Zn (Zn methionine), nano-ZnO and Znmix (organic Zn and nano-ZnO) at a concentration of 50 mg/kg of diet. After 42 days of feeding trial, the group supplemented with nano-ZnO exhibited the best final body weight and feed conversion ratio (2380 g/bird and 1.69, respectively). Nano-ZnO and Zn-mix supplementation significantly increased crude fat retention (86.70 and 86.75%, respectively). All sources of supplemented Zn other than inorganic ZnO significantly increased (P<0.05) Zn retention especially in the group supplemented with nano-ZnO (41.8%). Organic Zn and/or nano-ZnO sources supplemented to broiler diets significantly increased (P<0.05) iron and copper contents in the hepatic tissue and Zn content in the tibia. The mean of serum total cholesterol, triglycerides and very low density lipoprotien were significantly reduced (P<0.05) by dietary supplementation of organic Zn and/or nano-ZnO. The activity of malondialdehyde was significantly decreased (P<0.05), while Cu/Zn superoxide dismutase activity was significantly increased (P<0.05) by addition nano-ZnO or Zn-mix. Dietary Zn-mix and nano-ZnO positively affected mRNA expression of insulin like growth factor-1 and growth hormone genes in broilers when compared to the inorganic ZnO source. The present findings prospected that replacing traditional inorganic ZnO source with nano-ZnO or combining nano-ZnO and Zn methionine at applied concentration, promoted the growth of broilers, enhanced Zn up take and antioxidant status without negative effect on selected minerals distribution in tissues.

show abstract

“…These includes alcohol dehydrogenase, alkaline phosphatase (ALP), aldolase, lactate dehydrogenase (LDH), RNA and DNA polymerases, reverse transcriptase, carboxypeptidase A, B, G and superoxide dismutase (SOD). Zn is essential for body's proper physiological functions like, normal growth ( Case and Carlson, 2002 ), reproduction ( Uchida et al., 2001 ), DNA synthesis, cell division and gene expression ( Prasad, 1991 ), photochemical processes of vision ( Suchý et al., 1998 ), wound healing ( Zhao et al., 2014 ), ossification ( Roughead and Kunkel, 1991 ), augmenting the immune system of the body ( Zhao et al., 2014 , Parashuramulu et al., 2015 ) through energy production, protein synthesis, protection of membranes from bacterial endotoxins and lymphocyte replication and antibody production ( Nockels, 1994 ). Zn is a component of the free radicals scavengers which are produced during different physiological processes ( Zhao et al., 2014 ), and is also required for the normal condition of epidermis, epithelium, skin and hooves ( Kruczynska, 2004 ).…”

Section: Introductionmentioning

confidence: 99%

Nano zinc, an alternative to conventional zinc as animal feed supplement: A review

et al. 2016

View full text Add to dashboard Cite

The uniqueness of Zn is that, it is the second most abundant trace element in the animal body but can't be stored in the body, thus regular dietary intake is required. Zinc oxide (ZnO) nanoparticles (NP) particles are being extensively used in paints, skin lotions pigments, food, electronics appliances, biological and pharmaceutical applications and many more. Zinc oxide nanoparticles are the specially prepared mineral salt having particle size of 1 to 100 nm. It promotes growth can act as antibacterial agent, modulates the immunity and reproduction of the animals. Both in lower and higher doses of specifications it has exhibited a variety of effects on animal performances. Apart from being highly bio-available, reports have already pointed out the growth promoting, antibacterial, immuno-modulatory and many more effects of nano zinc (nZn). These can be used at lower doses and can provide better result than the conventional Zn sources and indirectly prevents environmental contamination also. The toxicological studies provide mixed results in animal models. Studies been undertaken in diversified animal species and encouraging effects have been reported with nZn supplementation. However, there is a need to optimize the dose and duration of ZnO NP supplementation for human and livestock, depending on its biological effects. Actual bioavailability of ZnO NP in livestock is still to be worked out. In this review we have attempted to summarize, conclude the beneficial effects of nZnO and its possible usage as mineral supplement to different categories of human and livestock.

show abstract

Effect of Zinc Supplementation on Antioxidant Status and Immune Response in Buffalo Calves

Cited by 25 publications

References 0 publications

Zinc and linoleic acid pre-treatment attenuates biochemical and histological changes in the midbrain of rats with rotenone-induced Parkinsonism

Zinc and linoleic acid pre-treatment attenuates biochemical and histological changes in the midbrain of rats with rotenone-induced Parkinsonism

Effects of Different Zinc Sources on Performance, Bio Distribution of Minerals and Expression of Genes Related to Metabolism of Broiler Chickens

Nano zinc, an alternative to conventional zinc as animal feed supplement: A review

Contact Info

Product

Resources

About