Effect of whole-body exposure to the 848.5 MHz code division multiple access (CDMA) electromagnetic field on adult neurogenesis in the young, healthy rat brain

Kim, Hye Sun; Kim, Yeon Ju; Lee, Yu Hee; Lee, Yun Sil; Choi, Hyung Do; Pack, Jeong‐Ki; Kim, Nam

doi:10.3109/09553002.2014.995382

Cited by 7 publications

(8 citation statements)

References 41 publications

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“…This experiment was performed using a whole‐body RFID exposure system that has been previously described [Kim et al, ,; Kim et al, ]. Briefly, a whole‐body exposure system for animal experiments (IRETEC, Anyang, Korea) with 915 MHz RFID was developed using a reverberation chamber [Jung et al, ].…”

Section: Methodsmentioning

confidence: 99%

“…We previously reported that exposure to 915 MHz RFID at a whole‐body specific absorption rate (SAR) of 4 W/kg had no statistically significant influence on the thyroid system [Kim et al, ] or on glucose metabolism [Kim et al, ]. Moreover, a code division multiple access (CDMA) signal at an SAR of 2 W/kg had no statistically significant influence on neurogenesis in adult rats [Kim et al, ]. Although RF‐EMFs were emitted in same or similar frequencies, if the modulation protocols for RF‐EMF were different, the biologic response could be different [Preece et al, ; Sukhotina et al, ; Kim et al, ,].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, a code division multiple access (CDMA) signal at an SAR of 2 W/kg had no statistically significant influence on neurogenesis in adult rats [Kim et al, ]. Although RF‐EMFs were emitted in same or similar frequencies, if the modulation protocols for RF‐EMF were different, the biologic response could be different [Preece et al, ; Sukhotina et al, ; Kim et al, ,].…”

Section: Introductionmentioning

confidence: 99%

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Effects of exposure to electromagnetic field from 915 MHz radiofrequency identification system on circulating blood cells in the healthy adult rat

Kim

Park

Jin

et al. 2017

Bioelectromagnetics

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We investigated whether exposure to the 915 MHz radiofrequency identification (RFID) signal affected circulating blood cells in rats. Sprague-Dawley rats were exposed to RFID at a wholebody specific absorption rate of 2 W/kg for 8 h per day, 5 days per week, for 2 weeks. Complete blood counts were performed after RFID exposure, and the CD4 þ /CD8 þ ratio was determined by flow cytometry. The number of red blood cells (RBCs) and the values of hemoglobin, hematocrit, and RBC indices were increased in the RFID-exposed group compared with those in the cagecontrol and sham-exposed groups (P < 0.05). However, the RBCs and platelet numbers were within normal physiologic response ranges. The number of white blood cells, including lymphocytes, was decreased in RFID-exposed rats. However, there was no statistically significant difference between the sham-exposed and RFID-exposed groups in terms of T-cell counts or CD4 þ /CD8 þ ratio (P > 0.05). Although the number of circulating blood cells was significantly altered by RFID exposure at a whole-body specific absorption rate of 2 W/kg for 2 weeks, these changes do not necessarily indicate that RFID exposure is harmful, as they were within the normal physiological response range. Bioelectromagnetics. 39:68-76, 2018.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of exposure to electromagnetic field from 915 MHz radiofrequency identification system on circulating blood cells in the healthy adult rat

Kim

Park

Jin

et al. 2017

Bioelectromagnetics

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“…Although that study was performed with a longer duration and stronger RF-EMF exposure than in the present study, no change was reported in neuronal cell fate. In our previous animal study with whole-body exposure to a 848.5-MHz CDMA signal at an SAR of 2 W/kg for 2 weeks, we observed no change in the numbers of BrdUpositive proliferating cells in the SVZ and DG [19]. Taken together with our previous report and the present study, although the experimental environments were different (local versus whole body, 1 day versus several weeks, and 915-MHz RFID versus 848.5-MHz CDMA), the RF-EMF exposure at an SAR of 2 W/kg had no harmful effects on neuronal cells in the adult rat brain.…”

Section: Resultsmentioning

confidence: 52%

“…A time delay in the process of neurite outgrowth may affect neurogenesis because neuronal activity is closely associated with the morphological maturation of neuronal cells [18]. According to our previous study with 848.5 MHz code division multiple access (CDMA) EMF, the differentiation of BrdU-positive cells in hippocampal DG and the SVZ were not affected after CDMA-EMF exposure at 2 W/kg SAR for 8 hours daily for 2 weeks in rats [19]. Previous studies could not demonstrate the influence of RF-EMFs on neurogenesis processes and on the fate of neuronal precursor cells in healthy adult rat brains.…”

Section: Effects Of 915 Mhz Radiofrequency Identification Electromagnmentioning

confidence: 96%

Effects of 915 MHz Radiofrequency Identification Electromagnetic Field Exposure on Neuronal Precursor Cells in the Dentate Gyrus of Adult Rat Brains

Kim¹,

Lee²,

Lee³

et al. 2015

Journal of electromagnetic engineering and science

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To explore the effects of radiofrequency electromagnetic field on the fate of neuronal cells, we investigated whether exposure to 915 MHz radiofrequency identification (RFID) caused morphological changes in neuronal cells in rat hippocampal dentate gyrus (DG). A reverberation chamber was used as a whole-body RFID exposure system. Rats were assigned to two groups: sham-and RFID-exposed groups. Rats in the RFID-exposed group were exposed to RFID at 4 W/kg specific absorption rate (SAR) for 8 hours daily, 5 days per week, for 2 weeks. Morphological evaluation of DG was performed using immunohistochemistry with doublecortin (DCX) as a neuronal precursor cell marker and neuronal nuclei (NeuN) as a mature neuronal cell marker. No significant morphological changes in DCX+ or NeuN+ cells in the DG of RFID-exposed rats were observed. These results suggest that RFID exposure induces no significant change in DCX+ neuronal precursor or NeuN+ neuronal cells in DG of rats.

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Metabolomic study of urinary polyamines in rat exposed to 915 MHz radiofrequency identification signal

et al. 2015

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Metabolomic analysis of urinary polyamines (PAs) from rat exposed to 915 MHz radiofrequency identification (RFID) signal for 8 h/day for 2 weeks was performed by gas chromatography-mass spectrometry as N-ethoxycarbonyl/N-pentafluoropropionyl derivatives. Large alterations in nine PA levels including four aliphatic and five acetylated PAs were monitored in sham-exposed and RFID-exposed groups. Total PA and urinary levels of N (1)-acetylputrescine, N (1)-acetylcadaverine, putrescine, cadaverine, N (1)-acetylspermidine, N (8)-acetylspermidine, spermidine and spermine were reduced, whereas N (1)-acetylspermine was significantly increased after sham and RFID exposure compared with those before exposure. Their levels were normalized to the corresponding group means before exposure and then plotted into star symbol patterns. N (1)-Acetylspermine after RFID exposure was 54 % higher compared to the level before RFID exposure, while it was elevated by only 17 % in the sham group. The results suggest that 915 MHz RFID exposure may induce metabolic disturbance of PA. It may also elevate spermidine/spermine acetyltransferase (SSAT) activity. Thus, the present metabolic profiling combined with star pattern recognition method might be useful for understanding the complexity of biochemical events after exposure to RFID signal.

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Effect of whole-body exposure to the 848.5 MHz code division multiple access (CDMA) electromagnetic field on adult neurogenesis in the young, healthy rat brain

Abstract: Our results suggest that exposure to the CDMA signal does not affect neurogenesis in the adult rat brain, at least under our experimental conditions.

Cited by 7 publications

References 41 publications

Effects of exposure to electromagnetic field from 915 MHz radiofrequency identification system on circulating blood cells in the healthy adult rat

Effects of exposure to electromagnetic field from 915 MHz radiofrequency identification system on circulating blood cells in the healthy adult rat

Effects of 915 MHz Radiofrequency Identification Electromagnetic Field Exposure on Neuronal Precursor Cells in the Dentate Gyrus of Adult Rat Brains

Metabolomic study of urinary polyamines in rat exposed to 915 MHz radiofrequency identification signal

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