Metabolomic study of urinary polyamines in rat exposed to 915 MHz radiofrequency identification signal

Abstract

Metabolomic analysis of urinary polyamines (PAs) from rat exposed to 915 MHz radiofrequency identification (RFID) signal for 8 h/day for 2 weeks was performed by gas chromatography-mass spectrometry as N-ethoxycarbonyl/N-pentafluoropropionyl derivatives. Large alterations in nine PA levels including four aliphatic and five acetylated PAs were monitored in sham-exposed and RFID-exposed groups. Total PA and urinary levels of N (1)-acetylputrescine, N (1)-acetylcadaverine, putrescine, cadaverine, N (1)-acetylspermidine, N (8)-acetylspermidine, spermidine and spermine were reduced, whereas N (1)-acetylspermine was significantly increased after sham and RFID exposure compared with those before exposure. Their levels were normalized to the corresponding group means before exposure and then plotted into star symbol patterns. N (1)-Acetylspermine after RFID exposure was 54 % higher compared to the level before RFID exposure, while it was elevated by only 17 % in the sham group. The results suggest that 915 MHz RFID exposure may induce metabolic disturbance of PA. It may also elevate spermidine/spermine acetyltransferase (SSAT) activity. Thus, the present metabolic profiling combined with star pattern recognition method might be useful for understanding the complexity of biochemical events after exposure to RFID signal.

Effect of Exposure to a Radiofrequency Electromagnetic Field on Body Temperature in Anesthetized and Non‐Anesthetized Rats

“…Also, 1 h of exposure to a 1,439‐MHz time‐division multiple access fields at a brain‐average SAR of 7.5 W/kg (peak SAR of 11 W/kg or whole‐body average SAR of 1.7 W/kg) did not alter the body temperature in rats, but such exposure at a brain‐average SAR of 25 W/kg (peak SAR of 39 W/kg or whole‐body average SAR of 5.7 W/kg) raised the body temperature by 2 °C [Yamaguchi et al, ]. However, in another study, exposure to an EMF at an average of 4 W/kg whole‐body SAR did not significantly alter the body temperature [Kim et al, ; Paik et al, ; Wyde et al, ].…”

Inkjet printed nanomaterial based flexible radio frequency identification (RFID) tag sensors for the internet of nano things

“…Kim et al 333 studied the effect of 915 MHz RFID exposure in rats where no change in thyroid secretory function in connection with triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) was observed in sham-exposed and RFID exposed rats. Paik et al 334 reported that 915 MHz RFID exposure alters urinary polyamines (PAs) in rats. The level of N 1 -acetylspermine was found to be 54% higher aer RFID exposure whereas it increased 17% in the sham group.…”

Metabolic Alterations Associated with γ-Hydroxybutyric Acid and the Potential of Metabolites as Biomarkers of Its Exposure

“…PA is being studied with a focus on cell growth, cell proliferation, protein, and nucleic acid synthesis by controlling its acetylation-deacetylation, according to changes in biochemical conditions [92][93][94]. Recently, studies on PA have focused on its role in a PA-mediated stress response signaling system and as a marker for monitoring and diagnosing various disease states [95][96][97]. Therefore, endogenous PA profile analysis is important for understanding biochemical changes post GHB exposure.…”