Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss

Jung, Sun Hye; Park, Hye Soon; Kim, Kyung Soo; Choi, Woong; Ahn, Chul Woo; Kim, Bom Taeck; Kim, Seon Mee; Lee, Seon Yeong; Ahn, Sang Mi; Kim, Yun Kyung; Kim, Hae Jin; Kim, Dae Jung; Lee, Kwan Woo

doi:10.1016/j.jnutbio.2007.05.007

Cited by 157 publications

(148 citation statements)

References 20 publications

(23 reference statements)

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“…[32] In an open-label study, sibutramine along with diet and exercise reduced the serum levels of the pro-inflammatory cytokines tumor necrosis factor α (TNFα) and interleukin 6 (IL-6) and increased the serum levels of the anti-inflammatory cytokine IL-10. [56] These anti-inflammatory effects most probably result from weight loss rather than from sibutramine treatment, but might contribute to a better CVD 6 risk profile. [32] Finally, sibutramine seems to favourably influence adipocytokines; it reduced serum leptin and resistin levels and increased adiponectin levels.…”

Section: Other Risk Factorsmentioning

confidence: 99%

Cardiovascular Risk-Benefit Profile of Sibutramine

Scheen

2010

American Journal Cardiovascular Drugs

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SUMMARYSibutramine is a combined norepinephrine and serotonin reuptake inhibitor used as an antiobesity agent to reduce appetite and promote weight loss in combination with diet and exercise. At a daily dose of 10-20 mg, it was initially considered to have a good safety profile as it does not induce primary pulmonary hypertension or adverse effects on cardiac valves, in contrast to what was previously reported with some other anti-obesity agents. However, it exerts

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Section: Other Risk Factorsmentioning

confidence: 99%

Cardiovascular Risk-Benefit Profile of Sibutramine

Scheen

2010

American Journal Cardiovascular Drugs

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“…12 In contrast, the anti-inflammatory cytokine IL-10 is decreased in these subjects. 13 In order to determine if a pro-inflammatory state associated with a type of gut microbiota is found in obese children, we investigated the correlation of Firmicutes and Bacteroidetes with both pro-or anti-inflammatory cytokines in this population.…”

Section: Introductionmentioning

confidence: 99%

High relative abundance of firmicutes and increased TNF-α levels correlate with obesity in children

et al. 2017

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Resumen Objetivo. Investigar la correlación entre las citocinas proinflamatorias o antiinflamatorias y los dos principales filos de la microbiota intestinal en niños obesos. Material y métodos. Se obtuvieron mediciones antropométricas de 890 niños de 6 a 14 años; posteriormente se clasificaron en normopeso y sobrepeso/obeso. Las concentraciones sé-ricas fueron medidas por el método de ELISA. La abundancia relativa de la microbiota intestinal en heces se evaluó por PCR tiempo real. Resultados. Los parámetros bioquímicos y antropométricos fueron estadísticamente más altos en niños con sobrepeso / obesidad que en niños delgados. Se encontraron niveles más altos de FNT-α en niños obesos que también tenían una abundancia relativa alta de Firmicutes. Conclusiones. Los niños obesos tienen una alta abundancia relativa de Firmicutes, la cual se correlaciona con un incremento de los niveles de FNT-α. Este es el primer estudio que evalúa la reacción entre la abundancia de Firmicutes y la concentración sérica de FNT-α en niños obesos.

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“…It should be noted that leptin stimulates CD4 + T-lymphocytes to produce the interferon-γ, which induces the adipocyte MHC II expression [2,9]. However, some anti-inflammatory cytokines such as ІL-10 and receptor antagonist ІL-1 (IL-1RA) decrease [10].…”

Section: Introductionmentioning

confidence: 99%

Probiotic strains of lactobacilli and bifidobacteria alter pro- and anti-inflammatory cytokines production in rats with monosodium glutamate-induced obesity

Falalyeyeva¹,

Leschenko²,

Берегова³

et al. 2017

Fiziol Zh

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The aim of this study was to investigate the effect of probiotic strains of Lactobacillus casei IMV B-7280, Bifidobacterium animalis VKL, B. animalis VKB on the pro-and anti-inflammatory cytokines production in Wistar male rats with monosodium glutamate (MSG)-induced obesity. It was established that neonatal administration of MSG to rats leads to increasing levels of the interleukin (IL)-1β and IL-12, and to decreasing of the IL-4, IL-10 and tumor growth factor (TGF)-β levels in the blood serum. After administration of the B. animalis VKL -B. animalis VKB -L. casei IMV B-7280 composition to obese rats the level of the IL-1β in blood serum wasn't differ from that in the obese rats, that didn't receive of the probiotic bacteria. But there was no statistically significant difference comparing with intact rats. The level of the IL-12B p40 in blood serum was decreased under influence of the B. animalis VKL -B. animalis VKB -L. casei IMV B-7280 composition (18.9 %, p < 0.05) and B. animalis VKL (10.5 %, p < 0.05) compared with obese rats, not receiving probiotic bacteria, but remained higher than in intact animals. After administration to obese rats of the B. animalis VKL -B. animalis VKB -L. casei IMV B-7280 composition the levels of the IL-4, IL-

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Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss

Cited by 157 publications

References 20 publications

Cardiovascular Risk-Benefit Profile of Sibutramine

Cardiovascular Risk-Benefit Profile of Sibutramine

High relative abundance of firmicutes and increased TNF-α levels correlate with obesity in children

Probiotic strains of lactobacilli and bifidobacteria alter pro- and anti-inflammatory cytokines production in rats with monosodium glutamate-induced obesity

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