Probiotic strains of lactobacilli and bifidobacteria alter pro- and anti-inflammatory cytokines production in rats with monosodium glutamate-induced obesity

Abstract

The aim of this study was to investigate the effect of probiotic strains of Lactobacillus casei IMV B-7280, Bifidobacterium animalis VKL, B. animalis VKB on the pro-and anti-inflammatory cytokines production in Wistar male rats with monosodium glutamate (MSG)-induced obesity. It was established that neonatal administration of MSG to rats leads to increasing levels of the interleukin (IL)-1β and IL-12, and to decreasing of the IL-4, IL-10 and tumor growth factor (TGF)-β levels in the blood serum. After administration of the B. animalis VKL -B. animalis VKB -L. casei IMV B-7280 composition to obese rats the level of the IL-1β in blood serum wasn't differ from that in the obese rats, that didn't receive of the probiotic bacteria. But there was no statistically significant difference comparing with intact rats. The level of the IL-12B p40 in blood serum was decreased under influence of the B. animalis VKL -B. animalis VKB -L. casei IMV B-7280 composition (18.9 %, p < 0.05) and B. animalis VKL (10.5 %, p < 0.05) compared with obese rats, not receiving probiotic bacteria, but remained higher than in intact animals. After administration to obese rats of the B. animalis VKL -B. animalis VKB -L. casei IMV B-7280 composition the levels of the IL-4, IL-

The potential cytoprotective effect of Vitamin C and Vitamin E on monosodium glutamate-induced testicular toxicity in rats

“…In the present study, MSG-treated rats had significantly higher levels of serum TNF-α and lower level of IL-10 when compared with the controls. These results were in accordance with other studies [25]. TNF-α initiates the activation cascade of cytokines, chemokines, and growth factors involved in the inflammatory response and therefore considered as a proinflammatory cytokine [26].IL-10 can suppress pro-inflammatory cytokine production [27].…”

A Review of the Alleged Health Hazards of Monosodium Glutamate

“…Neonatal administration of MSG (4 mg/g, s.c., days 2, 4, 6, 8, and 10 of life) to rats, led to elevated serum concentrations of interleukin (IL)‐1β and IL‐12, with a lowering of IL‐4, IL‐10, and tumor growth factor (TGF)‐β levels (Falalyeyeva et al., ). During the acute phase response of inflammatory stress, in newborn MSG‐treated (4 mg/g, i.p., day 2 of life) rats, the corticotropic‐adrenal response, leptin, insulin, and triglyceride levels were higher, pro‐inflammatory cytokine response was impaired, and anti‐inflammatory cytokine response remained normal.…”

Probiotics as a therapeutic strategy in obesity and overweight: a systematic review

“…In this sense, treatments with L. plantarum CGMCC1.557, L. fermentum CGMCC1.1880, B. breve CICC 6182 and L.casei CRL 431 showed an improvement in the composition of the intestinal bacteria, along with reduced levels of IL-1β, IL-6, IL-17, TNF-α and LPS and increased levels of IL-10, which had anti-inflammatory properties in mice fed with high-fat diets (HFD mice) and E.coli-induced endotoxemia (Novotny-Núñez et al, 2015;Sun et al, 2020). Similarly, a probiotic mixture containing B. animalis VLK and VKB and L. casei IMV B-7280 increased the levels of IL-4, IL-10 and TGF-β in rats with monosodium glutamate-induced obesity (Falalyeyeva et al, 2017). In this vein, L. plantarum was shown as a promising strain for the reduction of hypercholesterolemia and adipogenesis in vitro experiments (Huang et al, 2019).…”