Pronounced spatial non-uniformity has been obtained of daytime sea surface temperature (SST) of the Dead Sea and of land surface temperature (LST) over areas adjacent to the Dead Sea. This non-uniformity was observed in the summer months, under uniform solar radiation. Our findings are based on Moderate Resolution Imaging Spectroradiometer (MODIS) data (2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016) on board the Terra and Aqua satellites. MODIS data showed that, on average for the 15-year study period, daytime SST over the eastern part of the lake (Te) exceeded by 5 • C that over the western part (Tw). This SST non-uniformity (observed in the absence of surface heat flow from land to sea at the eastern side) was accompanied by spatial non-uniform distribution of land surface temperature (LST) over areas adjacent to the Dead Sea. Specifically, LST over areas adjacent to the eastern side exceeded by 10 • C that over areas adjacent to the western side. Our findings of spatial non-uniformity of SST/LST based on MODIS data were supported by Meteosat Second Generation LST records. Regional atmospheric warming led to a decrease in spatial non-uniformity of SST during the study period. Temperature difference between Te and Tw steadily decreased at the rate of 0.32 • C decade −1 , based on MODIS/Terra data, and 0.54 • C decade −1 , based on MODIS/Aqua data. Our simulations of monthly skin temperature distribution over the Dead Sea by the Weather Forecast and Research (WRF) model contradict satellite observations. The application to modeling of the observed SST/LST spatial non-uniformity will advance our knowledge of atmospheric dynamics over hypersaline lakes. the daytime. Little is known about the patterns of Dead Sea surface temperature. Nehorai et al. [3] discussed that the SST field is heterogeneous in the daytime and homogeneous in the nighttime. Kishcha et al. [7] showed that, in the summer months, the spatial distribution of daytime Dead Sea surface temperature was non-uniform with maximal SST observed near the coastline, while minimal SST was observed in the middle of the Dead Sea. Further investigation of spatial non-uniformity of SST will advance the general understanding of SST-related atmospheric processes not only over the Dead Sea but also over other hypersaline lakes.Buoy measurements of temperature vertical profiles in the Dead Sea provide information about water temperature at different depths [3,[8][9][10][11]. There are several studies on the Dead Sea SST [3,7,[12][13][14]. Kishcha et al. [7] showed that increasing warming of steadily shrinking Dead Sea surface water was observed during the period of 2000-2016. They found that a positive feedback loop between steady shrinking of the Dead Sea and positive sea surface temperature trends causes the acceleration of Dead Sea evaporation and water level drop [7].Available remote sensing observations of skin surface temperature from MODIS on board the two satellites-Terra and Aqua [15,16]-provided us with an opportun...