Effect of vitamin E isoforms on the primary intention skin wound healing of diabetic rats

Elsy, Bijo; Khan, Aijaz Ahmed; Maheshwari, Veena

doi:10.7241/ourd.20174.108

Cited by 9 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have shown that modification of T3 with one or more epoxide moieties on their polyisoprene side-chains resulted in an increase in the synthesis of endogenous lipid soluble antioxidant co-enzyme Q (CoQ) [296]. It is interesting to note that both topical and oral administration of T3 produced positive results on wound healing properties [295,[297][298][299][300]. Accelerated healing rate resulted in earlier wound contraction.…”

Section: Effects Of Tocotrienol On Wound Healingmentioning

confidence: 99%

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

et al. 2020

View full text Add to dashboard Cite

Tocotrienol (T3) is a subfamily of vitamin E known for its wide array of medicinal properties. This review aimed to summarize the health benefits of T3, particularly in prevention or treatment of non-communicable diseases (NCDs), including cardiovascular, musculoskeletal, metabolic, gastric, and skin disorders, as well as cancers. Studies showed that T3 could prevent various NCDs, by suppressing 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in the mevalonate pathway, inflammatory response, oxidative stress, and alternating hormones. The efficacy of T3 in preventing/treating these NCDs is similar or greater compared to tocopherol (TF). TF may lower the efficacy of T3 because the efficacy of the combination of TF and T3 was lower than T3 alone in some studies. Data investigating the effects of T3 on osteoporosis, arthritis, and peptic ulcers in human are limited. The positive outcomes of T3 treatment obtained from the preclinical studies warrant further validation from clinical trials.Nutrients 2020, 12, 259 2 of 84 Nutrients 2020, 12, 259 4 of 84 the order δ > γ > β > α [45]. Using HepG2 cells, γT3 was shown to stimulate apolipoprotein B (Apo-B) degradation by decreasing its translocation into the endoplasmic reticulum (ER) lumen. This action eventually caused a reduction in the number of Apo-B in lipoprotein particles [46]. Other reports showed that γT3 and δT3 had the potential to reduce the hepatic TG synthesis and very-low-density lipoprotein (VLDL) secretion by suppressing expression of genes involved in lipid homeostasis, particularly the TG, cholesterol, and VLDL biosynthesis. Moreover, δT3 also promoted the efflux of LDL through LDL receptor expression [47]. A summary of the literature on effect of T3 supplementation on lipid profile of hypercholesterolemic model in vitro is shown in Table 1.Animal models of dyslipidemia have been used to investigate the effects of T3 on lipid profile. Several animals have been tested, including chicken, swine and rodents (rats, hamsters, guinea pigs). In chickens fed with a varying level of αTF and γT3, Qureshi et al. (1996) showed that αTF enhanced the inhibition of HMGCR by γT3. They further stipulated that the vitamin E mixture should contain 15-20% of αTF and approximately 60% of γT3 or δT3 for optimal anti-cholesterol effects [48]. In the subsequent study, demonstrated that combination of 50 ppm T3-rich fraction (TRF) and 50 ppm lovastatin was more effective in suppressing HMGCR activity compared to lovastatin alone in chickens. The combination also reduced serum TC and LDL-C, TG, Apo-B, thromboxane B 2 , and platelet factor 4 in contrast to individual treatment [49]. Using chicken supplemented with 50 ppm of δT3, Qureshi et al. (2011) further revealed that δT3 reduced TC and LDL-C besides suppressing the lipid elevating effects of dexamethasone and potentiated the TG-lowering effect of riboflavin [50]. Using genetically hypercholesterolemic swine, Qureshi et al. (1991) demonstrated the significant effect of TRF in lowering serum TC, LDL-C, Apo-B, thrombo...

show abstract

Section: Effects Of Tocotrienol On Wound Healingmentioning

confidence: 99%

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

et al. 2020

View full text Add to dashboard Cite

show abstract

“…These stages require complex collaborative efforts from many different cells to achieve optimum healing of the skin wound (Hussan et al 2018;Latiff et al 2010). In diabetes, the normal wound healing process is impaired, mainly resulted from the oxidative stress by free radicals (Elsy et al 2017). VCO is widely known as an antioxidant agent, due to the phenolic compounds present (Marina et al 2009).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Virgin Coconut Oil on Fibroblasts and Myofibroblasts on Diabetic Wound Healing

Teoh¹

2019

View full text Add to dashboard Cite

Penyembuhan luka yang lambat adalah salah satu komplikasi utama diabetes melitus yang sering menyebabkan amputasi. Minyak kelapa dara (VCO) adalah minyak semulajadi yang kerap digunakan dalam rawatan luka. Ia mempamerkan aktiviti antioksidan dan antibakteria. Tujuan kajian ini adalah untuk menentukan kesan VCO terhadap fibroblas dalam proses penyembuhan luka diabetik. Luka kulit ketebalan penuh diambil daripada tikus diabetik yang tidak dapat rawatan, yang dirawat VCO dan perak sulfadiazine (SS). Tisu luka kemudiannya diproses untuk pewarnaan Verhoeff eosin dan imunohistologi untuk fibroblas dan miofibroblast. Analisis histologi menunjukkan peningkatan serat kolagen dengan epidermis yang utuh dalam kumpulan VCO berbanding dengan tisu luka tidak dirawat dan yang mendapat rawatan SS. Sel fibroblas dan miofibroblast diperhatikan lebih banyak dalam kumpulan tidak dirawat berbanding dengan kumpulan dirawat VCO dan SS. VCO mempercepatkan proses penyembuhan luka dengan ketara dalam tikus diabetik dengan meningkatkan proses epithelialisasi, penghasilan serat kolagen dan penguncupan luka. Hasil daripada penyelidikan ini mencadangkan VCO boleh digunakan untuk merawat luka diabetik.

show abstract

“…In many studies, the oral and topical administration of tocochromanols was found to elicit wound healing efficacy. All of the findings regarding tocochromanols, when alone or in formulation with other molecules, demonstrated them fostering angiogenesis, epithelisation, granulation, and collagen production, accounting for rapid wound contraction and tissue regeneration [ 158 , 195 , 196 , 197 , 198 , 199 ].…”

Section: Natural and Semi-synthetic Compounds For Wound Healingmentioning

confidence: 99%

Antibiotics-Free Compounds for Chronic Wound Healing

2022

View full text Add to dashboard Cite

The rapid rise in the health burden associated with chronic wounds is of great concern to policymakers, academia, and industry. This could be attributed to the devastating implications of this condition, and specifically, chronic wounds which have been linked to invasive microbial infections affecting patients’ quality of life. Unfortunately, antibiotics are not always helpful due to their poor penetration of bacterial biofilms and the emergence of antimicrobial resistance. Hence, there is an urgent need to explore antibiotics-free compounds/formulations with proven or potential antimicrobial, anti-inflammatory, antioxidant, and wound healing efficacy. The mechanism of antibiotics-free compounds is thought to include the disruption of the bacteria cell structure, preventing cell division, membrane porins, motility, and the formation of a biofilm. Furthermore, some of these compounds foster tissue regeneration by modulating growth factor expression. In this review article, the focus is placed on a number of non-antibiotic compounds possessing some of the aforementioned pharmacological and physiological activities. Specific interest is given to Aloe vera, curcumin, cinnamaldehyde, polyhexanide, retinoids, ascorbate, tocochromanols, and chitosan. These compounds (when alone or in formulation with other biologically active molecules) could be a dependable alternative in the management or prevention of chronic wounds.

show abstract

Effect of vitamin E isoforms on the primary intention skin wound healing of diabetic rats

Cited by 9 publications

References 16 publications

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

The Effects of Virgin Coconut Oil on Fibroblasts and Myofibroblasts on Diabetic Wound Healing

Antibiotics-Free Compounds for Chronic Wound Healing

Contact Info

Product

Resources

About