Effect of vitamin C on collagen structure of cardinal and uterosacral ligaments during pregnancy

Fındık, Rahime Bedir; İlkaya, Fatih; Güreşçi, Servet; Guzel, Hasan; Karabulut, Seda; Karakaya, Jale

doi:10.1016/j.ejogrb.2016.03.022

Cited by 15 publications

(7 citation statements)

References 17 publications

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“… 34 , 35 It has also been reported in several animal studies that administration of a very high dose of vitamin C results in an increase in collagen density in the mesenchymal tissue. 36 , 37 , 38 But these studies differ from ours in the amount of vitamin C administered, which can be as much as 75–100 mg/kg per day. As a result, we can assume that any supplement targeting an increase in collagen synthesis through the known effects of vitamin C should have meticulous dose-effect studies and possibly intoxication studies as well.…”

Section: Discussioncontrasting

confidence: 57%

“…To overcome this problem, further studies are needed with deficient animal models, but to our knowledge there are no proven deficient animal models or reported deficiency for any of our trial supplement's ingredients, except vitamin C. It is known that in-vitro fibroblast cultures treated with vitamin C exhibit increased synthesis of COL1 34, 35. It has also been reported in several animal studies that administration of a very high dose of vitamin C results in an increase in collagen density in the mesenchymal tissue 36, 37, 38. But these studies differ from ours in the amount of vitamin C administered, which can be as much as 75–100 mg/kg per day.…”

Section: Discussionmentioning

confidence: 92%

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Role of a combination dietary supplement containing mucopolysaccharides, vitamin C, and collagen on tendon healing in rats

Gemalmaz¹,

Sariyilmaz²,

Özkunt³

et al. 2018

Acta Orthopaedica et Traumatologica Turcica

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ObjectiveThe aim of this study was to investigate the effect of mucopolysaccharide, vitamin C, and collagen supplementation on the healing of Achilles tendon in rats.MethodsSixteen rats were separated into 2 groups. Both Achilles tendons of all rats were transected 5 mm above the insertion and repaired using a Kessler suture. After the surgical repair, the study group received the daily recommended amount of the supplement by gastric gavage, while the control group received a placebo. At the end of the third week, the animals were sacrificed. The biomechanical properties of the groups were compared with ultimate tensile strength and stiffness tests. The biological properties of the 2 groups were assessed with a histomorphometric comparison to determine the amount of collagen type I (COL1), proliferating cell nuclear antigen (PCNA), and transforming growth factor β1 (TGF-β1) expression in 3 different tissue subgroups (collagen matrix, tenocytes, and endotenon fibroblasts).ResultsAnalysis of histomorphometric results revealed that the rats receiving dietary supplements demonstrated a significant increase in PCNA (mean value of 86 in the control group and 168.85 in the trial group; p < 0.05) and TGF-β1 (mean value of 87.57 in the control group and 161.85 in the trial group; p < 0.05) in the endotenon fibroblasts of the repair site. However, there was no difference between the groups in PCNA or TGF-β1 when the collagen matrix and the tenocytes of the repair site were examined. Furthermore, no significant difference could be found between groups in COL1 in any of the 3 tissue subgroups (collagen matrix, tenocytes, and endotenon fibroblasts). The statistical analysis also indicated that the rats receiving supplements did not demonstrate a significant increase in the ultimate tendon tensile strength or stiffness.ConclusionThe results of this study revealed no advantage to the oral administration of the trial supplement in collagen synthesis or biomechanical properties in rats after 3 weeks using the presented study design. However, the increased expression of PCNA and TGFβ1 seen in the endotenon fibroblasts of the repair site might play a role in the continuum of tendon healing.

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 92%

Role of a combination dietary supplement containing mucopolysaccharides, vitamin C, and collagen on tendon healing in rats

Gemalmaz¹,

Sariyilmaz²,

Özkunt³

et al. 2018

Acta Orthopaedica et Traumatologica Turcica

View full text Add to dashboard Cite

show abstract

“…Vitamin C participates in several biological functions, such as enhancing collagen formation (Findik et al, 2016), and is considered one of the principal vitamins required by the human body due to its antioxidant properties (Padayatty & Levine, 2016;Podmore et al, 1998). Indeed, the increased intake of antioxidants has been associated with a lower risk of cardiovascular disease (Ellingsen et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Vitamin C stability in acerola and camu-camu powder obtained by spray drying

Garcia

Borges

Vanin

et al. 2020

Braz. J. Food Technol.

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Acerola and camu-camu fruits possess high vitamin C content. However, since these fruits are little consumed in their fresh form, it is important to consider that vitamin C can be oxidized depending on storage conditions. Thus, this study aimed to produce acerola and camu-camu powders by spray drying to maintain the stability of their vitamin C content during storage. Acerola and camu-camu powders were characterized in relation to their physicochemical characteristics, antioxidant activity, and vitamin C concentration and stability under different storage conditions (30 °C and 40 °C, 75% relative humidity). In general, the powders were proven to be stable, with low water activity (< 0.40) and humidity (< 4.0 g/100 g powder), as well as high vitamin C concentrations (1593.2 and 6690.4 mg/100 g of powder for acerola and camu-camu, respectively). Furthermore, we observed a high antioxidant activity by ABTS●+, DPPH• and FRAP assays. The powders stored at lower temperature (30 °C) showed higher vitamin C stability. In conclusion, acerola and camu-camu powders produced by spray drying are potential sources of vitamin C and active compounds and are therefore suitable for several food industry applications.

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“…To our knowledge, only two studies addressed the topic of antioxidant supplementation as a preventive precaution of POP. Unfortunately both used animal models [ 25 , 26 ]. Both studies show promising results.…”

Section: Discussionmentioning

confidence: 99%

Is there an association between pelvic organ prolapse and oxidative stress? A systematic review

et al. 2022

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Introduction and hypothesis The pathophysiology of pelvic organ prolapse (POP) has not been fully elucidated, although accumulating evidence suggests that oxidative stress is involved. The present systematic review comprehensively discusses this topic. Methods The PubMed/Medline, Scopus, and Web of Science databases were searched for relevant studies published up to May 2021. This systematic review was registered in the PROSPERO database (registration number CRD42021242240). Two independent researchers screened and selected articles that fulfilled predefined inclusion criteria, performed a quality assessment, and extracted the relevant data. Of 901 original articles retrieved, 8 fulfilled the selection criteria and were included in the review. Results Elevated levels of markers of oxidative stress, such as advanced glycation end products, hydroxynonenal and hydroxydeoxyguanosine, were found in various parts of the pelvic floor of patients with POP. Accordingly, the levels of glutathione peroxidase and superoxide dismutase, known as major antioxidant enzymes, were reduced, compared to those in healthy controls. Levels of two other markers (mitofusin 2 and nuclear factor erythroid derived 2) also support hypotheses suggesting the involvement of oxidative stress in POP. Conclusions In the literature available, an association between oxidative stress and pelvic organ prolapse was confirmed.

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Effect of vitamin C on collagen structure of cardinal and uterosacral ligaments during pregnancy

Cited by 15 publications

References 17 publications

Role of a combination dietary supplement containing mucopolysaccharides, vitamin C, and collagen on tendon healing in rats

Role of a combination dietary supplement containing mucopolysaccharides, vitamin C, and collagen on tendon healing in rats

Vitamin C stability in acerola and camu-camu powder obtained by spray drying

Is there an association between pelvic organ prolapse and oxidative stress? A systematic review

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