Is there an association between pelvic organ prolapse and oxidative stress? A systematic review

Abstract

Introduction and hypothesis The pathophysiology of pelvic organ prolapse (POP) has not been fully elucidated, although accumulating evidence suggests that oxidative stress is involved. The present systematic review comprehensively discusses this topic. Methods The PubMed/Medline, Scopus, and Web of Science databases were searched for relevant studies published up to May 2021. This systematic review was registered in the PROSPERO database (registration number CRD42021242240). Two independent researchers screened and selected articles that fulfilled predefined inclusion criteria, performed a quality assessment, and extracted the relevant data. Of 901 original articles retrieved, 8 fulfilled the selection criteria and were included in the review. Results Elevated levels of markers of oxidative stress, such as advanced glycation end products, hydroxynonenal and hydroxydeoxyguanosine, were found in various parts of the pelvic floor of patients with POP. Accordingly, the levels of glutathione peroxidase and superoxide dismutase, known as major antioxidant enzymes, were reduced, compared to those in healthy controls. Levels of two other markers (mitofusin 2 and nuclear factor erythroid derived 2) also support hypotheses suggesting the involvement of oxidative stress in POP. Conclusions In the literature available, an association between oxidative stress and pelvic organ prolapse was confirmed.

Single-cell analysis of uterosacral ligament revealed cellular heterogeneity in women with pelvic organ prolapse

“…In addition, we found that smooth muscle cells and macrophages in the uterosacral ligament showed strong expression of stress-response genes 45 . SMCs3-speci c marker CFHR1 can bind to necrotic oxidized low-density lipoprotein and strongly induces in ammasome NLRP3 in monocytes and neutrophils by exposure to EMR2 and then secretes pro-in ammatory cytokines such as IL-1β, IL-6.IL18, and TNFα 30,31 .…”

Single-cell analysis of uterosacral ligament revealed cellular heterogeneity in women with pelvic organ prolapse

“…In addition, we found that smooth muscle cells and macrophages in USL showed strong expression of stress-response genes 45 . SMCs3-specific marker CFHR1 can bind to necrotic oxidized low-density lipoprotein and strongly induces inflammasome NLRP3 in monocytes and neutrophils by exposure to EMR2 and then secretes pro-inflammatory cytokines such as IL-1β , IL-6 , IL18 , and TNFα 30 , 31 .…”