Effect of vitamin B12, folate, and dietary supplements on breast carcinoma chemotherapy–induced mucositis and neutropenia

Branda, Richard F.; Naud, Shelly; Brooks, Marjory B.; Chen, Zhuan; Muss, Hyman B.

doi:10.1002/cncr.20484

Cited by 47 publications

(35 citation statements)

References 60 publications

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“…The release behavior of KA from the KA-CS-MNPs and KA-PEG-MNPs nanocomposites can be described by different kinetics models, pseudo first-order (Equation 2), 60 ln (q e -q t ) = ln q e -kt (2) t/q t = 1/k q e 2 + t/q e (3)…”

Section: In Vitro Release Study Of Ka From the Nanocompositesmentioning

confidence: 99%

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Novel kojic acid-polymer-based magnetic nanocomposites for medical applications

Hussein‐Al‐Ali¹,

Zowalaty²,

Hussein³

et al. 2014

IJN

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Iron oxide magnetic nanoparticles (MNPs) were synthesized by the coprecipitation of iron salts in sodium hydroxide followed by coating separately with chitosan (CS) and polyethylene glycol (PEG) to form CS-MNPs and PEG-MNPs nanoparticles, respectively. They were then loaded with kojic acid (KA), a pharmacologically bioactive natural compound, to form KA-CS-MNPs and KA-PEG-MNPs nanocomposites, respectively. The MNPs and their nanocomposites were characterized using powder X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis, vibrating sample magnetometry, and scanning electron microscopy. The powder X-ray diffraction data suggest that all formulations consisted of highly crystalline, pure magnetite Fe 3 O 4 . The Fourier transform infrared spectroscopy and thermogravimetric analysis confirmed the presence of both polymers and KA in the nanocomposites. Magnetization curves showed that both nanocomposites (KA-CS-MNPs and KA-PEG-MNPs) were superparamagnetic with saturation magnetizations of 8.1 emu/g and 26.4 emu/g, respectively. The KA drug loading was estimated using ultraviolet–visible spectroscopy, which gave a loading of 12.2% and 8.3% for the KA-CS-MNPs and KA-PEG-MNPs nanocomposites, respectively. The release profile of the KA from the nanocomposites followed a pseudo second-order kinetic model. The agar diffusion test was performed to evaluate the antimicrobial activity for both KA-CS-MNPs and KA-PEG-MNPs nanocomposites against a number of microorganisms using two Gram-positive (methicillin-resistant Staphylococcus aureus and Bacillus subtilis ) and one Gram-negative ( Salmonella enterica ) species, and showed some antibacterial activity, which could be enhanced in future studies by optimizing drug loading. This study provided evidence for the promise for the further investigation of the possible beneficial biological activities of KA and both KA-CS-MNPs and KA-PEG-MNPs nanocomposites in nanopharmaceutical applications.

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Section: In Vitro Release Study Of Ka From the Nanocompositesmentioning

confidence: 99%

“…It is given to patients for treatment, or it may aim to prolong lifetimes or to palliate cancer symptoms. Traditional chemotherapy has limitations such as immunosuppression, 1 mucositis, 2 and alopecia. 3 These limitations are due to the nonselectivity of antineoplastic drugs, thus affecting normal cells as well as cancerous cells.…”

Section: Introductionmentioning

confidence: 99%

Novel kojic acid-polymer-based magnetic nanocomposites for medical applications

Hussein‐Al‐Ali¹,

Zowalaty²,

Hussein³

et al. 2014

IJN

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“…Quantitative phytochemical screening showed that tannins and polyphenols were the most abundant phytochemicals present in both leaf extracts as shown on Table 3. Alkaloids have shown efficient therapeutic properties asan anticancer, analgesic, antispasmodic and antibacterial properties (Yakubu et al, 2009;Branda et al, 2004). Both natural and synthetic alkaloids have been used as basic medicinal agent.…”

Section: Statistical Analysis Of Datamentioning

confidence: 99%

“…The leaves (either fresh or dried) are cooked into a thick viscous soup or added to stew or soup and are rich sources of vitamins and minerals (Branda et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…Nutritionally, C. olitorius on an average contain 85-87g H2O, 0.7g oil, 5g carbohydrate, 1.5g fiber, 250-266mg Ca, 4.8mg Fe, 1.5mg vitamin A, 0.1mg thiamine, 0.3mg riboflavin, 1.5mg nicotinamide, and 53-100mg ascorbic acid per 100g (Branda et al, 2004). Leaves decoction is used for treating iron deficiency, folic acid deficiency, as well as treatment of anemia and as blood purifier, while the leaf twigs are used against heart troubles (Krivanek et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Cochorous olitorous and Adasonia digitata leaves extracts protects against gamma radiation induced anaemia

Nwozo¹,

Bello²

2015

Plant Sci Today

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This paper proposes that exposure to radiation could generate free radicals, which could lead to disorders such as heamolysis-induced anaemia. We evaluated the radioprotective potentials of Cochorous olitorious and Adasonia digitata methanol leaves extract in gamma radiation induced anaemia. Fifty four adult male Wistar rats were divided into nine groups of 6 animals. Except for the control group, the other the animals were treated with a single dose of whole body gamma radiation of 6Gy and received either 500 or 1000 mg/kg body weight (bwt) of A. digitata and C. olitorious either singly or combination and vitamin C was used as reference. A. digitata and C. olitorious were screened for phytochemical content and had saponin (16.59±1.85 and 22.12±0.24), tannins (311.98±0.01 and 287.07±0.16), polyphenols (170.90±0.68 and 330.07±0.32), alkaloids (81.56±0.56 and 68.65±2.05) and flavonoids (25.38±2.88 and 157.38±0.38) respectively. There was significant loss in body weight, depletion in red blood cells (RBC), packed cell volume (PCV), heamoglobin concentration (HBC) in untreated rats exposed to gamma radiation. Administration of the plant extract to rats exposed to radiation was able to attenuate and ameliorate loss in body weight and changes in blood cells (HBC, PCV, PLT and RBC) especially in radiated rats on combination therapy of both extracts at 1000 mg/kg bwt group. Hepatoprotective and safety evaluation was done by measuring the serum ALT, AST and ALP, these parameters were significantly (p<0.05) increased in untreated rats exposed to gamma radiation compared to normal control rats and these decreased in rats on plant extract.

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Dietary intake effects on severity of cancer treatment‐induced mucositis: A cross‐sectional study

Manifar,

Tonkaboni,

Sobhanifar

et al. 2023

Health Science Reports

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Background and AimsOral mucositis is one of the most serious complications due to chemotherapy and radiotherapy in head and neck cancer treatment. Oral mucositis causes a wide range of clinical signs and symptoms, such as ulcers, pain, and dysphagia. Additionally, because of speech limitations, patients' self‐esteem will decrease, ultimately causing reduced quality of life. The primary objective of this study was to investigate the role of diet in the onset and progress of mucositis induced by chemotherapy and radiation therapy in patients with cancers.MethodsIn this study, 121 patients with a mean age of 51.43 ± 13.08 years were selected randomly and referred to the cancer institute, where they underwent their first phase of chemotherapy. In this step, patients were examined and their severity of oral mucositis was graded according to the World Health Organization criteria. They completed a 3‐day allergen food recall and dietary recommendations were met. After completing the forms, four questionnaires were filled out for each patient, the patient's nutrition was analyzed using the N4 software, and the amount of macro‐ and micronutrients was measured.ResultsMicronutrients such as aspartic acid, glycine, serine, proline, alanine, arginine, glutamic acid, and vitamin B12 and macronutrients such as rose water, sausage, beverages, coffee, and lamb meat were examined, and a significant difference was observed between groups (grade 1 and 2 mucositis) (p < 0.005). In patients with grade 2 mucositis, a lower level of vitamin B12 was reported (p < 0.005). There is a negative correlation between amounts of macro‐ and micronutrients and grades of oral mucositis.ConclusionIt can be concluded that diet plays a considerable role in the severity of oral mucositis caused by cancer treatment.

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Effect of vitamin B12, folate, and dietary supplements on breast carcinoma chemotherapy–induced mucositis and neutropenia

Cited by 47 publications

References 60 publications

Novel kojic acid-polymer-based magnetic nanocomposites for medical applications

Novel kojic acid-polymer-based magnetic nanocomposites for medical applications

Cochorous olitorous and Adasonia digitata leaves extracts protects against gamma radiation induced anaemia

Dietary intake effects on severity of cancer treatment‐induced mucositis: A cross‐sectional study

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