Effect of vegetarian soy diet on hyperlipidaemia in nephrotic syndrome

D’Amico, Giuseppe; Gentile, Maria Gabriella; Manna, G. M.; Fellin, G; Ciceri, Maria Rita; Cofano, F.; Petrini, Concetta; Lavarda, F; Perolini, S.; Porrini, Marisa

doi:10.1016/0140-6736(92)90731-h

Cited by 108 publications

(51 citation statements)

References 20 publications

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“…These factors are all known to affect the metabolism of TG-rich lipoproteins. Previous studies also reported that soybean protein decreased the fasting plasma lipid concentration when lipids levels of subjects were elevated by dietary or genetic factors, or by chronic diseases (high fat intake, familial hypercholesterolemia (17,33), renal disease (34), nephrotic syndrome (34,35)). In this study, however, all the subjects were normolipidemic, and the fasting levels of plasma lipids and apolipo proteins were not affected by SPI or casein intake.…”

Section: Discussionmentioning

confidence: 99%

Effects of Soy Protein Isolate (SPI) and Casein on the Postprandial Lipemia in Normolipidemic Men.

Shige

Ishikawa

Higashi

et al. 1998

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryTo elucidate the effects of soybean protein and casein on postprandial lipemia, oral fat load tests were performed before and 3 weeks after the administration of soy protein isolate (SPI) and casein supplement to normolipidemic men. Eleven normolipidemic male subjects on otherwise identical controlled diets were assigned to either a 20g/d soy protein isolate (SPI) dietary supplement or a casein dietary supple ment for three weeks in a crossover design. Fat load tests with 40g/m2 of bovine milk fat were carried out before and after 3weeks on the ex perimental dietary supplements. Fasting plasma concentrations of lipids and apolipoproteins were not significantly different from baseline levels before or after the administration of SPI or casein supplemented diets. Neither SPI nor casein supplement affected the fasting plasma con centrations of lipids and apolipoproteins. The areas under the incre mental curve (AUIC) of triglyceride (TG) and remnant-like particles triglyceride (RLP-TG) after both experimental diets were not significantly different from those before the experimental diets. However, the AUIC of remnant-like particles cholesterol (RLP-C) showed a tendency (p= 0.07) to decrease after administration of the diet supplemented with SPI than before the diet. The AUIC of RLP-C was significantly (p<0.05) lower after the diet supplemented with SPI than after administration of the diet supplemented with casein. These results suggest that 3weeks of 20g/d SPI dietary supplement favorably affects the postprandial remnant lipoprotein response as compared to the casein dietary supplement.

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Section: Discussionmentioning

confidence: 99%

Effects of Soy Protein Isolate (SPI) and Casein on the Postprandial Lipemia in Normolipidemic Men.

Shige

Ishikawa

Higashi

et al. 1998

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Such lipid abnormalities may predispose to more rapid progression of the renal disease. 4 Therefore, correction of lipid abnormalities or their prevention when possible, in patients with nephrotic syndrome, could be a protective factor against its progression.…”

Section: Introductionmentioning

confidence: 99%

Short-term effects of soy protein diet in patients with proteinuric glomerulopathies

Ahmed¹,

Calabria²,

Kirsztajn³

2011

J. Bras. Nefrol.

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“…Step I diet in hypercholesterolaemic individuals with normal renal function (Anderson et al 1995;Baum et al 1998;Sirtori et al 1999;Teixeira et al 2000), and in patients with nephrotic syndrome or diabetic nephropathy (D'Amico et al 1992;Azadbakht et al 2003;Teixeira et al 2004). Our previous study demonstrated that soya protein improved the serum lipid profile in animals with renal failure (Chen et al 2003).…”

mentioning

confidence: 99%

Effect of soya protein on serum lipid profile and lipoprotein concentrations in patients undergoing hypercholesterolaemic haemodialysis

Chen

Yang

et al. 2006

Br J Nutr

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Clinical trials have shown that soya protein reduces the concentrations of some atherogenic lipids in subjects with normal renal function. The present study examined the effects of soya protein on serum lipid concentrations and lipoprotein metabolism in patients on hypercholesterolaemic haemodialysis. Twenty-six hypercholesterolaemic (total cholesterol $ 6·21 mmol/l) patients on haemodialysis were studied in a randomized, double-blind, placebo-controlled clinical trial. After a 4-week run-in phase, the subjects were randomly assigned to two groups. Isolated soya protein or milk protein 30 g was consumed daily as a beverage at breakfast or post-dialysis for 12 weeks. Soya protein substitution resulted in significant reductions in total cholesterol (17·2 (SD 8·9 )%), LDL-cholesterol (15·3 (SD 12·5 )%), apo B (14·6 (SD 12·1 )%) and insulin (23·8 (SD 18·7) %) concentrations. There were no significant changes in HDL-cholesterol or apo A-I. These results indicate that replacing part of the daily protein intake with soya protein has a beneficial effect on atherogenic lipids and favourably affects lipoprotein metabolism in hypercholesterolaemic patients undergoing haemodialysis.

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Effect of vegetarian soy diet on hyperlipidaemia in nephrotic syndrome

Cited by 108 publications

References 20 publications

Effects of Soy Protein Isolate (SPI) and Casein on the Postprandial Lipemia in Normolipidemic Men.

Effects of Soy Protein Isolate (SPI) and Casein on the Postprandial Lipemia in Normolipidemic Men.

Short-term effects of soy protein diet in patients with proteinuric glomerulopathies

Effect of soya protein on serum lipid profile and lipoprotein concentrations in patients undergoing hypercholesterolaemic haemodialysis

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