Effect of soya protein on serum lipid profile and lipoprotein concentrations in patients undergoing hypercholesterolaemic haemodialysis

Chen, Shu-Tzu; Chen, Jiun‐Rong; Yang, Chin-Sheng; Peng, Sheng-Jeng; Ferng, Shyang-Hwa

doi:10.1079/bjn20051646

Cited by 31 publications

(20 citation statements)

References 30 publications

(35 reference statements)

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“…Also, some research indicates that soy protein, when substituted for animal protein, decreases urinary protein levels in individuals with chronic renal disease and in patients with diabetes [167,168,169,170,171]. In addition, recent data suggest that soyfoods may also be useful for dialysis patients [172,173,174,175] and may have advantages for renal transplant patients [176]. …”

Section: Role Of Soy In Reducing Vegetarian Risk Of Chronic Diseasementioning

confidence: 99%

The Role of Soy in Vegetarian Diets

Messina

2010

Nutrients

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Soyfoods have long been prized among vegetarians for both their high protein content and versatility. Soybeans differ markedly in macronutrient content from other legumes, being much higher in fat and protein, and lower in carbohydrate. In recent years however, soyfoods and specific soybean constituents, especially isoflavones, have been the subject of an impressive amount of research. Nearly 2,000 soy-related papers are published annually. This research has focused primarily on the benefits that soyfoods may provide independent of their nutrient content. There is particular interest in the role that soyfoods have in reducing risk of heart disease, osteoporosis and certain forms of cancer. However, the estrogen-like effects of isoflavones observed in animal studies have also raised concerns about potential harmful effects of soyfood consumption. This review addresses questions related to soy and chronic disease risk, provides recommendations for optimal intakes, and discusses potential contraindications. As reviewed, the evidence indicates that, with the exception of those individuals allergic to soy protein, soyfoods can play a beneficial role in the diets of vegetarians. Concerns about adverse effects are not supported by the clinical or epidemiologic literature. Based on the soy intake associated with health benefits in the epidemiologic studies and the benefits noted in clinical trials, optimal adult soy intake would appear to be between two and four servings per day.

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Section: Role Of Soy In Reducing Vegetarian Risk Of Chronic Diseasementioning

confidence: 99%

The Role of Soy in Vegetarian Diets

Messina

2010

Nutrients

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“…However, the metaanalysis of several randomized controlled trials showed that soy protein and soy isoflavones have positive effects on the blood lipid profile [34,35]. In addition, the replacement of daily protein with soy protein for 8 to 12 weeks results in a reduction in total cholesterol, triglyceride, low-density lipoprotein, and Apo-lipoprotein B 100 (Apo-B 100) [36,37].…”

Section: Discussionmentioning

confidence: 99%

Education and Protein Supplementation Improve Nutritional Biomarkers among Hypoalbuminemic Peritoneal Dialysis Patients: A Quasi-Experimental Design

et al. 2019

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Protein-energy wasting is prevalent in peritoneal dialysis patients, which causes a heavy burden for individuals and healthcare systems. We aimed to investigate the effect of nutritional education, and/or protein supplementation on nutritional biomarkers in hypoalbuminemic peritoneal dialysis patients. A quasi-experimental study was conducted in two dialysis centers at Taipei Tzu Chi Hospital and Shin Kong Wu Ho-Su Memorial Hospital. Patients were allocated in three groups including control (n = 12), milk protein (n = 21) and soy protein (n = 20). All patients received dietary guidelines from dietitians and completed 3-day dietary records during monthly visits for consecutive three months. Nutrients were analyzed using Nutritionist Professional software. Blood urea nitrogen (BUN), creatinine, albumin, total protein, hemoglobin, serum calcium, phosphorus, sodium, and potassium were assessed monthly. Total cholesterol and triglycerides were measured every three months. After three-month intervention, protein intake (percent of total calories), and serum albumin were significantly increased in three groups. Protein, phosphorus intake, and BUN were increased in two intervention groups. Total serum protein increased in control and milk protein groups, and creatinine increased the control group. Serum phosphorus was not significantly changed. Nutritional education alone, or combined with protein supplementation, significantly improve protein intake, and nutritional status by increasing serum albumin, but not serum phosphorus in hypoalbuminemic peritoneal dialysis patients.

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“…A surprising finding, when comparing recent with earlier studies using soya protein, given as a total dietary substitute, is that even with partial substitution or just addition, remarkable cholesterol reductions occurred in severely hypercholesterolaemic individuals. This was particularly noticeable in two papers on patients on dialysis, in which 30 g/d soya protein were included in the diet as a drink (Chen et al 2005(Chen et al , 2006. A paper that has compared different daily soya protein intakes in hypercholesterolaemic individuals seems to indicate that increasing the intake above 30 g/d does not improve the response (Tonstad et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Hypocholesterolaemic effects of soya proteins: results of recent studies are predictable from the Anderson meta-analysis data

2007

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In 1995, Anderson et al. published a meta-analysis, derived from most of the clinical studies on soya proteins given to individuals with varying levels of cholesterolaemia that had been reported up to that time. The meta-analysis clearly indicated that cholesterolaemias were generally reduced by diets with soya given as a partial or total substitution of animal proteins, with final mean total and LDL-cholesterol reductions of 23·2 mg/dl and 21·7 mg/dl, respectively. These findings were recently strongly criticised, based on the evaluation of later studies, frequently involving individuals with normal or moderately elevated cholesterolaemias. In the present paper, these more recent studies were re-evaluated using a 'nomogram' prepared on the basis of the quartiles of initial cholesterol concentrations in the Anderson meta-analysis and their corresponding CI for net cholesterol change. The five studies belonging to the first quartile and thirteen out of the fourteen belonging to the second quartile gave results perfectly in line with the nomogram. Out of the fourteen studies belonging to the third quartile, ten agreed with the nomogram and two gave lower cholesterol reductions, whereas two gave higher reductions. Unfortunately, none of the recent studies belonged to the fourth quartile as treatment with statins or other lipid-lowering drugs is now mandatory in the presence of very high cholesterol levels. The re-evaluation thus shows that the thirty-three studies published in the past 10 years are in agreement with the Anderson meta-analysis and confirm its validity.

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Effect of soya protein on serum lipid profile and lipoprotein concentrations in patients undergoing hypercholesterolaemic haemodialysis

Cited by 31 publications

References 30 publications

The Role of Soy in Vegetarian Diets

The Role of Soy in Vegetarian Diets

Education and Protein Supplementation Improve Nutritional Biomarkers among Hypoalbuminemic Peritoneal Dialysis Patients: A Quasi-Experimental Design

Hypocholesterolaemic effects of soya proteins: results of recent studies are predictable from the Anderson meta-analysis data

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