Effect of Vascular Targeting Agent in Rat Tumor Model: Dynamic Contrast-enhanced versus Diffusion-weighted MR Imaging

Thoeny, Harriet C.; Keyzer, Frederik De; Vandecaveye, Vincent; Chen, Feng; Sun, Xiaojiang; Bosmans, Hilde; Hermans, Robert; Verbeken, Eric; Boesch, Chris; Marchal, Guy; Landuyt, Willy; Ni, Yicheng

doi:10.1148/radiol.2372041638

Cited by 151 publications

(111 citation statements)

References 25 publications

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“…There was also substantial to excellent agreement regarding the evaluation of response at conventional MR imaging, DWI, and DCE imaging (k = 0.795, 0.840, and 0.773, respectively), and excellent agreement in the measurements of the ADCs (intraclass correlation coefficient, 0.8335; 95% confidence interval, 0.7729, 0.8791). response in soft-tissue sarcomas (20), although it can show tumor volume reduction from pretreatment imaging, as well as cystic regions presumed to be tumor necrosis (21,27,28 with alterations in tumor perfusion after neoadjuvant treatment, and ADCs are inversely related to tumor cellularity (17). Unlike DCE, DWI is a noncontrast technique and a potentially useful alternative for assessing response in patients with contraindications to the use of contrast material.…”

Section: Discussionmentioning

confidence: 99%

“…Hence, the functional MR imaging techniques of DWI and DCE imaging may offer a more accurate assessment of histologic response, as suggested for other organ systems (9-13), and for osteosarcoma (5,6,(14)(15)(16). However, limited reports exist regarding the use of DWI (17)(18)(19) and DCE imaging for Abbreviations: ADC = apparent diffusion coefficient DCE = dynamic contrast enhanced DWI = diffusion-weighted imaging…”

Section: Study Populationmentioning

confidence: 99%

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Multiparametric Assessment of Treatment Response in High-Grade Soft-Tissue Sarcomas with Anatomic and Functional MR Imaging Sequences

Soldatos¹,

Ahlawat²,

Montgomery³

et al. 2016

Radiology

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).q RSNA, 2015 Purpose:To determine the added value of quantitative diffusionweighted and dynamic contrast material-enhanced imaging to conventional magnetic resonance (MR) imaging for assessment of the response of soft-tissue sarcomas to neoadjuvant therapy. Materials and Methods:MR imaging examinations in 23 patients with soft-tissue sarcomas who had undergone neoadjuvant therapy were reviewed by two readers during three sessions: conventional imaging (T1-weighted, fluid-sensitive, static postcontrast T1-weighted), conventional with diffusion-weighted imaging, and conventional with diffusion-weighted and dynamic contrast-enhanced imaging. For each session, readers recorded imaging features and determined treatment response. Interobserver agreement was assessed and receiver operating characteristic analysis was performed to evaluate the accuracy of each session for determining response by using results of the histologic analysis as the reference standard. Good response was defined as less than or equal to 5% residual viable tumor. Results:Of the 23 sarcomas, four (17.4%) showed good histologic response (three of four with .95% granulation tissue and ,5% necrosis, one of four with 95% necrosis and ,5% viable tumor) and 19 (82.6%) showed poor response (viable tumor range, 10%-100%). Interobserver agreement was substantial or excellent for imaging features in all sequences (k = 0.789-1.000). Receiver operating characteristic analysis showed an increase in diagnostic performance with the addition of diffusion-weighted and dynamic contrast-enhanced MR imaging for prediction of response compared with that for conventional imaging alone (areas under the curve, 0.500, 0.676, 0. Conclusion:Adding functional sequences to the conventional MR imaging protocol increases the sensitivity of MR imaging for determining treatment response in soft-tissue sarcomas.q RSNA, 2015

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Section: Discussionmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Multiparametric Assessment of Treatment Response in High-Grade Soft-Tissue Sarcomas with Anatomic and Functional MR Imaging Sequences

Soldatos¹,

Ahlawat²,

Montgomery³

et al. 2016

Radiology

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“…18 Because of the increased vascularity and cellularity of tumor tissues and in‰ammatory lesions, the contribution of intravascular water diŠusion may account for a signiˆcant proportion of the MR signal. 19,20 DWI is useful for detecting malignancies and evaluating their activity before and after treatment. 21 Like T 2 -weighted imaging, DWI may be valuable …”

Section: Dišusion-weighted Imaging For Detecting Andmentioning

confidence: 99%

Hepatosplenic and Muscular Sarcoidosis: Characterization with MR Imaging

Sekine¹,

Amano²,

Hidaka³

et al. 2012

magn reson med sci

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Sarcoidosis is a multisystem disorder of unknown etiology that involves multiple organs. Computed tomography is theˆrst-line imaging modality for diagnosing sarcoidosis because of its capacity to detect hilar lymphadenopathy and pulmonary lesions. Magnetic resonance (MR) imaging provides good soft tissue contrast that is useful for detecting sarcoidosis in some body parts, including skeletal muscle. Signal intensity on pre-and postcontrast T 1 -and T 2 -weighted imaging may re‰ect disease activity and the pathological appearance of sarcoidosis. In this review, we demonstrate these conventional MR imaginĝ ndings of hepatosplenic and muscular sarcoidosis and describe the usefulness of diŠusion-weighted imaging for detecting sarcoidosis.

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“…Diffusion-weighted MRI (DW-MRI) has been used to image the tumor cell necrosis that results from a positive response to CA4P treatment, with a range of preclinical studies done in a rat rhabdomyosarcoma (13,14). In these studies, changes in apparent diffusion coefficient (ADC) were highly dependent on the timing of the DW-MRI measurements relative to the administration of the treatment.…”

Section: Introductionmentioning

confidence: 99%

Detection of Tumor Response to a Vascular Disrupting Agent by Hyperpolarized 13C Magnetic Resonance Spectroscopy

Bohndiek

Kettunen

et al. 2010

Molecular Cancer Therapeutics

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Nuclear spin hyperpolarization can dramatically increase the sensitivity of the 13 C magnetic resonance experiment, allowing dynamic measurements of the metabolism of hyperpolarized 13 C-labeled substrates in vivo. Here, we report a preclinical study of the response of lymphoma tumors to the vascular disrupting agent (VDA), combretastatin-A4-phosphate (CA4P), as detected by measuring changes in tumor metabolism of hyperpolarized [1- C]pyruvate and lactate was decreased by 34% within 6 hours of CA4P treatment and remained at this lower level at 24 hours. The rate constant describing production of labeled malate from hyperpolarized [1,[4][5][6][7][8][9][10][11][12][13] C 2 ]fumarate increased 1.6-fold and 2.5-fold at 6 and 24 hours after treatment, respectively, and correlated with the degree of necrosis detected in histologic sections. Although DCE-MRI measurements showed a substantial reduction in perfusion at 6 hours after treatment, which had recovered by 24 hours, DW-MRI showed no change in the apparent diffusion coefficient of tumor water at 6 hours after treatment, although there was a 32% increase at 24 hours (P < 0.02) when regions of extensive necrosis were observed by histology. Measurements of hyperpolarized [1- C 2 ]fumarate metabolism may provide, therefore, a more sustained and sensitive indicator of response to a VDA than DCE-MRI or DW-MRI, respectively. Mol Cancer Ther; 9(12); 3278-88. Ó2010 AACR.

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Effect of Vascular Targeting Agent in Rat Tumor Model: Dynamic Contrast-enhanced versus Diffusion-weighted MR Imaging

Cited by 151 publications

References 25 publications

Multiparametric Assessment of Treatment Response in High-Grade Soft-Tissue Sarcomas with Anatomic and Functional MR Imaging Sequences

Multiparametric Assessment of Treatment Response in High-Grade Soft-Tissue Sarcomas with Anatomic and Functional MR Imaging Sequences

Hepatosplenic and Muscular Sarcoidosis: Characterization with MR Imaging

Detection of Tumor Response to a Vascular Disrupting Agent by Hyperpolarized 13C Magnetic Resonance Spectroscopy

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