Purpose: To assess the myocardial damage in hypertrophic cardiomyopathy (HCM) using contrast-enhanced myocardial T1-weighted scout (Look-Locker) magnetic resonance imaging (MRI).
Materials and Methods:Twenty-three patients with HCM and seven comparative patients without known HCM serving as controls underwent cine, contrast-enhanced myocardial T1-weighted scout and delayed-enhancement MRI using a 1.5T unit. Intervals of null points between myocardium and blood were compared among hyperenhancing and nullified myocardium of HCM and the normal myocardium. The relationship between these myocardial patterns and global cardiac functions was analyzed in HCM.
Results:The hyperenhancing myocardium, dense myocardial fibrosis in HCM had null points significantly shorter than blood, normal myocardium, and nullified myocardium of HCM (P Ͻ 0.0001). The number of hyperenhancing myocardial segments correlated with the ejection fraction (P ϭ 0.045). The nullified myocardium of HCM showed shorter intervals of the null points between myocardium and blood than did the normal myocardium, indicating the dispersed myocardial fibrosis (P ϭ 0.0032). The interval of null points between the nullified myocardium and blood showed a significant correlation with the increase in myocardial mass in HCM (P ϭ 0.034).
Conclusion:Contrast-enhanced myocardial T1-weighted scout imaging has the potential for showing dispersed myocardial damage leading to increased myocardial mass in HCM, while the dense myocardial fibrosis correlated with reduced ejection fraction.
Purpose:To assess the usefulness of non-contrast-enhanced MR angiography using cardiac and navigator-gated magnetization-prepared three-dimensional (3D) steadystate free precession (SSFP) imaging for the diagnosis of diseases of the thoracic aorta.
Materials and Methods:Twenty-two patients with diseases of the thoracic aorta were examined using a 1.5 Tesla unit. Non-contrast-enhanced MR angiography was done using parasagittal 3D SSFP combined with cardiac-gating and k-space weighted navigator-gating techniques, using T2-prepared and fat-suppression pulses. Imaging quality and the diagnostic capability of this technique were compared with the imaging quality of 2D SSFP or contrastenhanced 3D MR angiography and with final diagnoses.Results: Non-contrast-enhanced 3D MR angiography provided signal-to-noise and contrast-to-noise ratios of the thoracic aorta comparable to non-contrast-enhanced 2D or contrast-enhanced 3D MR angiography (P Ͼ 0.17). This imaging technique gave accurate diagnoses in 19 of the 22 patients.
Conclusion:Non-contrast-enhanced MR angiography using cardiac and navigator-gated magnetization-prepared 3D SSFP technique was useful for the diagnosis of diseases of the thoracic aorta.
This study confirms that MR imaging is able to depict the characteristic internal signal of GCTTS. Moreover, it can accurately assess the tumor size and degree of extent around the phalanx, which can affect the type of surgical approach.
Purpose: A drawback of time-resolved 3-dimensional phase contrast magnetic resonance (4D Flow MR) imaging is its lengthy scan time for clinical application in the brain. We assessed the feasibility for flow measurement and visualization of 4D Flow MR imaging using Cartesian y-z radial sampling and that using k-t sensitivity encoding (k-t SENSE) by comparison with the standard scan using SENSE.Materials and Methods: Sixteen volunteers underwent 3 types of 4D Flow MR imaging of the brain using a 3.0-tesla scanner. As the standard scan, 4D Flow MR imaging with SENSE was performed first and then followed by 2 types of acceleration scan-with Cartesian y-z radial sampling and with k-t SENSE. We measured peak systolic velocity (PSV) and blood flow volume (BFV) in 9 arteries, and the percentage of particles arriving from the emitter plane at the target plane in 3 arteries, visually graded image quality in 9 arteries, and compared these quantitative and visual data between the standard scan and each acceleration scan.Results: 4D Flow MR imaging examinations were completed in all but one volunteer, who did not undergo the last examination because of headache. Each acceleration scan reduced scan time by 50% compared with the standard scan. The k-t SENSE imaging underestimated PSV and BFV (P < 0.05). There were significant correlations for PSV and BFV between the standard scan and each acceleration scan (P < 0.01). The percentage of particles reaching the target plane did not differ between the standard scan and each acceleration scan. For visual assessment, y-z radial sampling deteriorated the image quality of the 3 arteries.Conclusion: Cartesian y-z radial sampling is feasible for measuring flow, and k-t SENSE offers sufficient flow visualization; both allow acquisition of 4D Flow MR imaging with shorter scan time.
Purpose: To evaluate the relationship between delayed hyper-enhancement of the myocardium and global and regional cardiac abnormalities in hypertrophic cardiomyopathy (HCM) with asymmetrical septal hypertrophy using magnetic resonance (MR) imaging.
Materials and Methods:Twenty-three patients with HCM with asymmetrical septal hypertrophy were examined using a 1.5-T MR unit. Contrast-enhanced inversion-recovery gradientecho imaging was performed to observe the myocardial damages associated with HCM. Balanced steady-state free precession imaging was performed to assess regional wall abnormalities and ejection fraction, and black-blood fast spin-echo imaging was performed to assess left atrial diameter.
Results:Delayed hyper-enhancement of the myocardium was primarily observed in the interventricular septal wall. Septal walls with the higher transmural extent of delayed hyper-enhancement were significantly thicker at end-diastole and end-systole (P Ͻ 0.05), and tended to show a decreased percentage systolic wall thickening (P ϭ 0.079). There were no differences in theses values between nonenhancing septal walls and septal walls with the transmural extent Ͻ 50%.
Conclusion:The high transmural extent of delayed hyperenhancement of the myocardium may reflect the severe myocardial damage associated with the regional hypertrophy and hypokinesia in HCM.
The purpose of this paper is to describe imaging techniques and findings of T2-weighted magnetic resonance imaging (MRI) of edema in myocardial diseases. T2-weighted cardiac MRI is acquired by combining acceleration techniques with motion and signal suppression techniques. The MRI findings should be interpreted based on coronary artery supply, intramural distribution, and comparison with delayed-enhancement MRI. In acute myocardial diseases, such as acute myocardial infarction and myocarditis, the edema is larger than myocardial scarring, whereas the edema can be smaller than the scarring in some types of nonischemic cardiomyopathy, including hypertrophic cardiomyopathy. T2-weighted MRI of edema identifies myocardial edema associated with ischemia, inflammation, vasculitis, or intervention in the myocardium and provides information complementary to delayed-enhancement MRI.
Single-shot spin-echo diffusion-weighted echo-planar imaging using a phased-array multicoil was performed to distinguish between normal and cirrhotic livers. Sets of 6 images with different b-values were acquired with breath-holding. Significant differences were observed between controls and cirrhosis cases in the signal ratios when the b-value was 383 s/mm2, and apparent diffusion coefficients.
Purpose:To assess the feasibility of free-breathing highspatial-resolution delayed contrast-enhanced three-dimensional (3D) viability magnetic resonance imaging (MRI) at 3.0T for the detection of myocardial damages.
Materials and Methods:Twenty-five patients with myocardial diseases, including myocardial infarction and cardiomyopathies, were enrolled after informed consent was given. Free-breathing 3D viability MRI with high spatial resolution (1.5 ϫ 1.25 ϫ 2.5 mm) at 3.0T, for which cardiac and navigator gating techniques were employed, was compared with breath-hold two-dimensional (2D) viability imaging (1.77 ϫ 1.18 ϫ 10 mm) for assessment of contrastto-noise ratio (CNR) and myocardial damage.Results: Free-breathing 3D viability imaging was achieved successfully in 21 of the 25 patients. This imaging technique depicted 84.6% of hyperenhancing myocardium with a higher CNR between hyperenhancing myocardium and blood and with excellent agreement for the transmural extension of myocardial damage (k ϭ 0.91). In particular, the 3D viability images delineated the myocardial infarction and linear hyperenhancing myocardium, comparable to the 2D viability images.
Conclusion:Free-breathing high-spatial-resolution delayed contrast-enhanced 3D viability MRI using 3.0T was feasible for the evaluation of hyperenhancing myocardium, as seen with myocardial infarction and cardiomyopathies.
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