Effect of varicocelectomy on serum inhibin B levels in infertile patients with varicocele

Özden, Cüneyt; Ozdal, Ozdem Levent; Bulut, Süleyman; Güzel, Özer; Koyuncu, Hakan; Memiş, Ali

doi:10.1080/00365590802028141

Cited by 34 publications

(30 citation statements)

References 14 publications

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“…Therefore, both PDRN and surgical treatment re-create a microenvironment where the Sertoli cells may normally function. In agreement with this hypothesis, it has been demonstrated (27,28) that varicocelectomy increases inhibin expression.…”

mentioning

confidence: 50%

Activation of adenosine A2A receptors by polydeoxyribonucleotide increases vascular endothelial growth factor and protects against testicular damage induced by experimental varicocele in rats

Minutoli¹,

Arena²,

Bonvissuto³

et al. 2011

Fertility and Sterility

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mentioning

confidence: 50%

Activation of adenosine A2A receptors by polydeoxyribonucleotide increases vascular endothelial growth factor and protects against testicular damage induced by experimental varicocele in rats

Minutoli¹,

Arena²,

Bonvissuto³

et al. 2011

Fertility and Sterility

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“…In men with severe oligoasthenoteratozoospermia, treatment of varicocele was associated with a significant increase in inhibin B levels and a significant decrease in FSH levels [8]. Some researchers have noted a significant improvement in serum inhibin B level after varicocelectomy and have concluded that combining this endocrine marker with a spermogram could be an effective guide to the effect of varicocelectomy on spermatogenesis [12, 30]. In contrast, our present results confirmed those of Fujisawa et al [11], in which the preoperative serum inhibin B concentration did not reliably predict the response to varicocelectomy.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effects of varicocele embolization on semen parameters

Prasivoravong

Marcelli²,

Lemaître

et al. 2014

Basic Clin. Androl.

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BackgroundThe value of varicocele repair and the latter's impact on semen parameters are still subject to debate.MethodsWe analyse changes over time in initially abnormal sperm parameters and serum concentrations of testosterone, FSH and inhibin B after embolization treatment of males with high-grade varicocele. From 2007 to 2012, we recruited 47 male infertile patients with clinically visible left varicocele in the resting patient and at least one abnormal semen parameter. Sperm parameters and serum levels of total testosterone, FSH and inhibin B were measured prior to retrograde embolization (M0) and then 3 (M3) and 6 (M6) months afterwards.ResultsAt M0, the median sperm concentration was 5.78 [0.84-37.70] × 106/ejaculate. The mean ± SD sperm progressive motility, vitality and percentage of normal sperm were respectively, 21.83 ± 16.48%, 61.88 ± 15.98% and 12.88 ± 7.15%. The corresponding values at M3 were significantly higher (38.75 [3.96-95] × 106/ejaculate, 29.32 ± 14.21%, 69.14 ± 14.86% and 19.03 ± 11.02%, respectively). The mean percentage of spermatozoa with a thin head was significantly lower at M6 (6.35 ± 5.29%) than at M0 (14.03 ± 13.09%). The mean serum testosterone, FSH and inhibin B levels did not change significantly over time.ConclusionsEmbolization treatment in men with clinically visible left varicocele, abnormal sperm parameters and documented infertility is associated with a significant improvement in semen parameters including sperm head morphology.

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“…It has been found to demonstrate a reverse correlation as testicular volume decreases in patients with varicocoele (Romeo et al, 2007). Because levels of inhibin B have also been found to increase or decrease non-specifically in some adolescents and adults, with or without surgical correction, there is poor evidence to support its clinical application (De Sanctis et al, 2007;Di Bisceglie et al, 2007;Ozden et al, 2008;Basar et al, 2010). For example, one analysis of variance study, between 50 men with varicocoele, 50 adolescents with varicocoele and 50 fertile adults without scrotal pathology, found no correlation of serum and seminal plasma inhibin-B levels between groups (Basar et al, 2010).…”

Section: Predictors Of Testicular Injury/indicators Of Surgerymentioning

confidence: 99%

Adolescent varicocoele management controversies

2012

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SUMMARYVaricocoele is defined as excessive dilatation of the pampiniform venous plexus of the spermatic cord. Varicocoele frequently appears during early puberty and is recognized to be the most common surgically correctable cause of male infertility. However, the actual incidence in adolescents, pathophysiology and the association with male factor infertility all remain somewhat controversial. The most accurate diagnostic technique for identifying young men who will benefit from surgical treatment has yet to be established. Observations of testicular asymmetry and deteriorating semen quality helped establish current guidelines and recommendations for surgical treatment. Further studies, comparing observation with surgical intervention, are needed to refine the current indications for varicocoele repair in the adolescent male.

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Effect of varicocelectomy on serum inhibin B levels in infertile patients with varicocele

Abstract: Serum inhibin B level as an endocrine marker combined with a spermogram could provide efficient data for evaluating the effect of varicocelectomy on spermatogenesis.

Cited by 34 publications

References 14 publications

Activation of adenosine A2A receptors by polydeoxyribonucleotide increases vascular endothelial growth factor and protects against testicular damage induced by experimental varicocele in rats

Activation of adenosine A2A receptors by polydeoxyribonucleotide increases vascular endothelial growth factor and protects against testicular damage induced by experimental varicocele in rats

Beneficial effects of varicocele embolization on semen parameters

Adolescent varicocoele management controversies

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