Activation of adenosine A2A receptors by polydeoxyribonucleotide increases vascular endothelial growth factor and protects against testicular damage induced by experimental varicocele in rats

Adenosine A2A-receptor agonist polydeoxyribonucleotide promotes gastric ulcer healing in Mongolian gerbils

“…PDRN interacts with the adenosine A 2A -receptor, stimulates VEGF expression, and facilitates wound healing (Minutoli et al 2011). The wound-healing activity of PDRN in diabetic foot ulcers was reported to be mediated through angiogenesis (Altavilla et al 2009).…”

Polydeoxyribonucleotide administration improves the intra-testicular vascularization in rat experimental varicocele

“…However, the positive role of VEGF in varicocele as a therapeutic target is limited by its poor bioavailability and the uncomfortable route of administration. This observation led to produce a safe induction of VEGF in an experimental model of varicocele in adolescent rats, through the administration of polydeoxyribonucleotide (PDRN) (11), an active fraction of a preparation used in therapy as an agent to stimulate tissue repair, extracted from sperm trout (11,12). The compound holds a mixture of deoxyribonucleotide polymers with chain lengths between 50 and 2000 bp and acts through the stimulation of adenosine A 2A -receptor.…”

Preparation of a novel composite nanofiber gel-encapsulated human placental extract through layer-by-layer self-assembly

“…Another study suggested that HPE exerts an anti-inflammatory function that suppresses chemical mediators, and that these effects may be associated with innate immune functions (36). Furthermore, previous studies indicated that oligomeric DNA nucleotides, such as polydeoxyribonucleotide (PDRN), are linear DNA nucleotide polymers from HPE with a length range of 50-2,000 bp (37,38). PDRN can efficiently activate adenosine A2A receptors, without being degraded into small fragments, thus preventing the activation of other adenosine receptors (39,40).…”