Effect of variations of corneal physiology on novel non-invasive intraocular pressure monitoring soft contact lens

Advancements in Wearable and Implantable Intraocular Pressure Biosensors for Ophthalmology: A Comprehensive Review

“…Although the study by Campigotto et al demonstrates the capability of CLBS to detect changes in IOP, critics of the technology may argue that variations in anatomy and physiology could affect the general applicability of these findings. For instance, corneal stiffness can be impacted by biochemical properties including central corneal thickness (CCT), radius of corneal curvature (RCC), corneal hysteresis, hydration, and age [63,64]. Critics can then argue that increasing corneal stiffness would decrease the deformation in the curvature of the eye, and thus render CLBS without effect.…”

“…Critics can then argue that increasing corneal stiffness would decrease the deformation in the curvature of the eye, and thus render CLBS without effect. However, in another study, researchers studied physiological variations in CCT and RCC and determined that these differences did not impact the measurements made with contact lens sensor [64]. The two variables, CCT and RCC, were specifically selected since these two variables were considered to be the most significant factors that can impact IOP measurement [64].…”

“…However, in another study, researchers studied physiological variations in CCT and RCC and determined that these differences did not impact the measurements made with contact lens sensor [64]. The two variables, CCT and RCC, were specifically selected since these two variables were considered to be the most significant factors that can impact IOP measurement [64]. Although the study by Campigotto et al demonstrates the capability of CLBS to detect changes in IOP, critics of the technology may argue that variations in anatomy and physiology could affect the general applicability of these findings.…”