Advancements in Wearable and Implantable Intraocular Pressure Biosensors for Ophthalmology: A Comprehensive Review

Wu, Kevin Y.; Mina, Mina; Carbonneau, Marjorie; Marchand, Michael; Tran, Simon D.

doi:10.3390/mi14101915

Cited by 8 publications

(2 citation statements)

References 183 publications

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“…Nonetheless, the control of IOP has retained its position as the primary therapeutic target in glaucoma management. This emphasis persists because modulation of IOP currently represents the only adjustable risk factor known to affect the disease’s progression, which underscores the critical nature of IOP management in glaucoma treatment strategies [ 147 ]. The application of biopolymer-based drug delivery systems in the management and treatment of glaucoma has been extensively researched.…”

Section: Biopolymeric Drugs Delivery Systemsmentioning

confidence: 99%

Biopolymeric Innovations in Ophthalmic Surgery: Enhancing Devices and Drug Delivery Systems

Wu,

Khan,

Liao

et al. 2024

Polymers

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The interface between material science and ophthalmic medicine is witnessing significant advances with the introduction of biopolymers in medical device fabrication. This review discusses the impact of biopolymers on the development of ophthalmic devices, such as intraocular lenses, stents, and various prosthetics. Biopolymers are emerging as superior alternatives due to their biocompatibility, mechanical robustness, and biodegradability, presenting an advance over traditional materials with respect to patient comfort and environmental considerations. We explore the spectrum of biopolymers used in ophthalmic devices and evaluate their physical properties, compatibility with biological tissues, and clinical performances. Specific applications in oculoplastic and orbital surgeries, hydrogel applications in ocular therapeutics, and polymeric drug delivery systems for a range of ophthalmic conditions were reviewed. We also anticipate future directions and identify challenges in the field, advocating for a collaborative approach between material science and ophthalmic practice to foster innovative, patient-focused treatments. This synthesis aims to reinforce the potential of biopolymers to improve ophthalmic device technology and enhance clinical outcomes.

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Section: Biopolymeric Drugs Delivery Systemsmentioning

confidence: 99%

Biopolymeric Innovations in Ophthalmic Surgery: Enhancing Devices and Drug Delivery Systems

Wu,

Khan,

Liao

et al. 2024

Polymers

Self Cite

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“…The worldwide market for wearables was USD 978.86 million in 2022 and is expected to grow to USD 4336.7 million by 2032 [10]. Another recent review by Wu et al outlined numerous advancements in intraocular pressure biosensor engineering [11]. This review aims to expand upon these articles by focusing on extraocular IOP sensors with integrated drug delivery capabilities.…”

Section: Introductionmentioning

confidence: 99%

Advances and Challenges in Wearable Glaucoma Diagnostics and Therapeutics

Shean,

Yu,

Guntipally

et al. 2024

Bioengineering

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Glaucoma is a leading cause of irreversible blindness, and early detection and treatment are crucial for preventing vision loss. This review aims to provide an overview of current diagnostic and treatment standards, recent medical and technological advances, and current challenges and future outlook for wearable glaucoma diagnostics and therapeutics. Conventional diagnostic techniques, including the rebound tonometer and Goldmann Applanation Tonometer, provide reliable intraocular pressure (IOP) measurement data at single-interval visits. The Sensimed Triggerfish and other emerging contact lenses provide continuous IOP tracking, which can improve diagnostic IOP monitoring for glaucoma. Conventional therapeutic techniques include eye drops and laser therapies, while emerging drug-eluting contact lenses can solve patient noncompliance with eye medications. Theranostic platforms combine diagnostic and therapeutic capabilities into a single device. Advantages of these platforms include real-time monitoring and personalized medication dosing. While there are many challenges to the development of wearable glaucoma diagnostics and therapeutics, wearable technologies hold great potential for enhancing glaucoma management by providing continuous monitoring, improving medication adherence, and reducing the disease burden on patients and healthcare systems. Further research and development of these technologies will be essential to optimizing patient outcomes.

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From lab to wearables: Innovations in multifunctional hydrogel chemistry for next-generation bioelectronic devices

Lee,

Yang,

Koirala

et al. 2024

Biomaterials

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Advancements in Wearable and Implantable Intraocular Pressure Biosensors for Ophthalmology: A Comprehensive Review

Cited by 8 publications

References 183 publications

Biopolymeric Innovations in Ophthalmic Surgery: Enhancing Devices and Drug Delivery Systems

Biopolymeric Innovations in Ophthalmic Surgery: Enhancing Devices and Drug Delivery Systems

Advances and Challenges in Wearable Glaucoma Diagnostics and Therapeutics

From lab to wearables: Innovations in multifunctional hydrogel chemistry for next-generation bioelectronic devices

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