Effect of ultra-processed diet on gut microbiota and thus its role in neurodegenerative diseases

Leo, Edwin E. Martínez; Campos, Maira Rubí Segura

doi:10.1016/j.nut.2019.110609

Cited by 108 publications

(76 citation statements)

References 69 publications

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“…The biofilm complexity is represented by the bacterial composition, but also by the existing interactions between the microorganisms themselves and between the microorganisms and their habitat; in fact, there are more than 700 bacterial species present in the bacterial plaque which exhibit different grades of pathogenesis towards the host [25]. Similarly, inside the oral cavity, different microenvironmental conditions can originate, influenced by the microbial composition and vice versa [26,27].…”

Section: Periodontal Diseasementioning

confidence: 99%

The Role of Periodontitis and Periodontal Bacteria in the Onset and Progression of Alzheimer’s Disease: A Systematic Review

Dioguardi

Crincoli

Laino

et al. 2020

JCM

128

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The evidence of a connection between the peripheral inflammatory processes and neurodegenerative diseases of the central nervous system is becoming more apparent. This review of the related literature highlights the most recent clinical, epidemiological, and in vitro studies trying to investigate possible connections between periodontal bacteria and the onset and progression of Alzheimer’s disease. This review was conducted by searching databases such as PubMed and Scopus using keywords or combinations such as Alzheimer’s Disease AND periodontal or dementia AND periodontitis OR periodontal. After eliminating overlaps and screening the articles not related to these issues, we identified 1088 records and proceeded to the selection of articles for an evaluation of the associative assumptions. The hypothesis suggested by the authors and confirmed by the literature is that the bacterial load and the inflammatory process linked to periodontal disease can intensify inflammation at the level of the central nervous system, favoring the occurrence of the disease. The analysis of the literature highlights how periodontal disease can directly contribute to the peripheral inflammatory environment by the introduction of periodontal or indirect pathogenic bacteria and proinflammatory cytokines locally produced at the periodontal level following bacterial colonization of periodontal defects.

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Section: Periodontal Diseasementioning

confidence: 99%

The Role of Periodontitis and Periodontal Bacteria in the Onset and Progression of Alzheimer’s Disease: A Systematic Review

Dioguardi

Crincoli

Laino

et al. 2020

JCM

128

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show abstract

“…An analysis by Partridge et al [121] suggested that emulsifiers contributed to alterations in the gut microbiota, with changes to the intestinal mucus layer, increased bacterial translocation, and an impact on the associated inflammatory response. The effect of ultra-processed food on gut microbiota deregulation was also described by Martinez et al [122], Viennois, and Chassaing [123], Suez et al [124]. A study conducted by Chassaing et al [123] on the influence of synthetic dietary emulsifiers polysorbate 80 (P80) and carboxymethylcellulose (CMC) on the gut microbiota revealed that both P80 and CMC affected deconstruction in the GM and led to increased expression of bacterial inflammatory molecules, such as flagellin [125].…”

Section: Western-style Diet (Wsd) and Gut Microbiotamentioning

confidence: 72%

You Are What You Eat—The Relationship between Diet, Microbiota, and Metabolic Disorders—A Review

2020

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The gut microbiota (GM) is defined as the community of microorganisms (bacteria, archaea, fungi, viruses) colonizing the gastrointestinal tract. GM regulates various metabolic pathways in the host, including those involved in energy homeostasis, glucose and lipid metabolism, and bile acid metabolism. The relationship between alterations in intestinal microbiota and diseases associated with civilization is well documented. GM dysbiosis is involved in the pathogenesis of diverse diseases, such as metabolic syndrome, cardiovascular diseases, celiac disease, inflammatory bowel disease, and neurological disorders. Multiple factors modulate the composition of the microbiota and how it physically functions, but one of the major factors triggering GM establishment is diet. In this paper, we reviewed the current knowledge about the relationship between nutrition, gut microbiota, and host metabolic status. We described how macronutrients (proteins, carbohydrates, fat) and different dietary patterns (e.g., Western-style diet, vegetarian diet, Mediterranean diet) interact with the composition and activity of GM, and how gut bacterial dysbiosis has an influence on metabolic disorders, such as obesity, type 2 diabetes, and hyperlipidemia.

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“…Data have shown that human gut microbiota in industrialized societies is very distinct from the recent ancestral microbiota of humans [ 48 ]. Ultra-processed foods modify the gut environment, being trigger factors for low-grade systemic inflammation and oxidative stress [ 73 ]. Recent work proposed the term “microbiota insufficiency syndrome”, and this could be linked to many non-communicable chronic diseases [ 74 ].…”

Section: Probiotics and Immunitymentioning

confidence: 99%

Can Probiotics and Diet Promote Beneficial Immune Modulation and Purine Control in Coronavirus Infection?

et al. 2020

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Infection caused by the SARS-CoV-2 coronavirus worldwide has led the World Health Organization to declare a COVID-19 pandemic. Because there is no cure or treatment for this virus, it is emergingly urgent to find effective and validated methods to prevent and treat COVID-19 infection. In this context, alternatives related to nutritional therapy might help to control the infection. This narrative review proposes the importance and role of probiotics and diet as adjunct alternatives among the therapies available for the treatment of this new coronavirus. This review discusses the relationship between intestinal purine metabolism and the use of Lactobacillus gasseri and low-purine diets, particularly in individuals with hyperuricemia, as adjuvant nutritional therapies to improve the immune system and weaken viral replication, assisting in the treatment of COVID-19. These might be promising alternatives, in addition to many others that involve adequate intake of vitamins, minerals and bioactive compounds from food.

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Effect of ultra-processed diet on gut microbiota and thus its role in neurodegenerative diseases

Cited by 108 publications

References 69 publications

The Role of Periodontitis and Periodontal Bacteria in the Onset and Progression of Alzheimer’s Disease: A Systematic Review

The Role of Periodontitis and Periodontal Bacteria in the Onset and Progression of Alzheimer’s Disease: A Systematic Review

You Are What You Eat—The Relationship between Diet, Microbiota, and Metabolic Disorders—A Review

Can Probiotics and Diet Promote Beneficial Immune Modulation and Purine Control in Coronavirus Infection?

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