Effect of theta burst stimulation over the human sensorimotor cortex on motor and somatosensory evoked potentials

Ishikawa, S.; Matsunaga, Kaoru; Nakanishi, Ryo; Kawahira, Kazumi; Murayama, Nobuki; Tsuji, Sadatoshi; Huang, Ying Zu; Rothwell, John C.

doi:10.1016/j.clinph.2007.02.003

Cited by 124 publications

(121 citation statements)

References 33 publications

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“…The current flow of the initial rising phase of the biphasic pulse in the TMS coil induced a current flowing from posterior to anterior in the brain. On the basis of the decreased amplitude of the somatosensory-evoked potentials after cTBS over a region situated at 2 cm posterior to M1 (Ishikawa et al, 2007), we assumed that cTBS over S1 EYE results in a decreased excitability of this area. The control site of stimulation in the parietal lobe, P3, was located by using the International 10-20 system for EEG placement.…”

Section: Tmsmentioning

confidence: 99%

Role of Oculoproprioception in Coding the Locus of Attention

Odoj

Balslev

2015

Journal of Cognitive Neuroscience

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Abstract■ The most common neural representations for spatial attention encode locations retinotopically, relative to center of gaze. To keep track of visual objects across saccades or to orient toward sounds, retinotopic representations must be combined with information about the rotation of one's own eyes in the orbits. Although gaze input is critical for a correct allocation of attention, the source of this input has so far remained unidentified. Two main signals are available: corollary discharge (copy of oculomotor command) and oculoproprioception (feedback from extraocular muscles). Here we asked whether the oculoproprioceptive signal relayed from the somatosensory cortex contributes to coding the locus of attention. We used continuous theta burst stimulation (cTBS) over a human oculoproprioceptive area in the postcentral gyrus (S1 EYE ). S1 EYE -cTBS reduces proprioceptive processing, causing ∼1°underestimation of gaze angle. Participants discriminated visual targets whose location was cued in a nonvisual modality. Throughout the visual space, S1 EYE -cTBS shifted the locus of attention away from the cue by ∼1°, in the same direction and by the same magnitude as the oculoproprioceptive bias. This systematic shift cannot be attributed to visual mislocalization. Accuracy of open-loop pointing to the same visual targets, a function thought to rely mainly on the corollary discharge, was unchanged. We argue that oculoproprioception is selective for attention maps. By identifying a potential substrate for the coupling between eye and attention, this study contributes to the theoretical models for spatial attention. ■

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Section: Tmsmentioning

confidence: 99%

Role of Oculoproprioception in Coding the Locus of Attention

Odoj

Balslev

2015

Journal of Cognitive Neuroscience

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“…80% of active motor threshold) in a short time, and it can evoke either facilitating or inhibiting effects according to the stimulation mode (intermittent [iTBS] or continuous [cTBS], respectively). In a recent paper, Ishikawa et al (2006) found that cTBS over sensory cortex reduced the amplitude of median nerve SEPs, particularly the P25 and later components, whereas cTBS over M1 had the opposite effect. The present short report complements that previous work by examining the effect of iTBS on SEPs to median nerve stimulation.…”

Section: Introductionmentioning

confidence: 93%

Modulation of somatosensory evoked potentials using transcranial magnetic intermittent theta burst stimulation

Katayama¹,

Rothwell²

2007

Clinical Neurophysiology

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“…Repetitive delivery of TMS pulses (rTMS) to a brain region modulates the excitability of the stimulated area, inducing changes in neural plasticity (Allen, Pasley, Duong, & Freeman, 2007). These neuroplastic changes outlast the duration of stimulation and are believed to be induced through long‐term potentiation/depression mechanisms (Esser et al, 2006; Ishikawa et al, 2007). High (>5 Hz) or low (<5 Hz) frequency stimulation results in a lasting increase or decrease in excitability, respectively (Esser et al, 2006; Valero‐Cabré, Payne, & Pascual‐Leone, 2007).…”

Section: Introductionmentioning

confidence: 99%

A novel concurrent TMS‐fMRI method to reveal propagation patterns of prefrontal magnetic brain stimulation

Vink

Mandija

Petrov

et al. 2018

Human Brain Mapping

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Major depressive disorder (MDD) is a severe mental disorder associated with high morbidity and mortality rates, which remains difficult to treat, as both resistance and recurrence rates are high. Repetitive transcranial magnetic stimulation (TMS) of the left dorsolateral prefrontal cortex (DLPFC) provides a safe and effective treatment for selected patients with treatment‐resistant MDD. Little is known about the mechanisms of action of TMS provided to the left DLPFC in MDD and we can currently not predict who will respond to this type of treatment, precluding effective patient selection. In order to shed some light on the mechanism of action, we applied single pulse TMS to the left DLPFC in 10 healthy participants using a unique TMS‐fMRI set‐up, in which we could record the direct effects of TMS. Stimulation of the DLPFC triggered activity in a number of connected brain regions, including the subgenual anterior cingulate cortex (sgACC) in four out of nine participants. The sgACC is of particular interest, because normalization of activity in this region has been associated with relief of depressive symptoms in MDD patients. This is the first direct evidence that TMS pulses delivered to the DLPFC can propagate to the sgACC. The propagation of TMS‐induced activity from the DLPFC to sgACC may be an accurate biomarker for rTMS efficacy. Further research is required to determine whether this method can contribute to the selection of patients with treatment resistant MDD who will respond to rTMS treatment.

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Effect of theta burst stimulation over the human sensorimotor cortex on motor and somatosensory evoked potentials

Cited by 124 publications

References 33 publications

Role of Oculoproprioception in Coding the Locus of Attention

Role of Oculoproprioception in Coding the Locus of Attention

Modulation of somatosensory evoked potentials using transcranial magnetic intermittent theta burst stimulation

A novel concurrent TMS‐fMRI method to reveal propagation patterns of prefrontal magnetic brain stimulation

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