Modulation of somatosensory evoked potentials using transcranial magnetic intermittent theta burst stimulation

Katayama, Takayuki; Rothwell, John C.

doi:10.1016/j.clinph.2007.08.011

Cited by 50 publications

(44 citation statements)

References 16 publications

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“…C1 after occipital pole stimulation (Schutter and van Honk 2003), distinct SEP-components after stimulation of sensory/motor cortices (e.g. Katayama and Rothwell 2007; Ishikawa et al 2007; Restuccia et al 2007), P300 after prefrontal stimulation (e.g. Evers et al 2001; Hansenne et al 2004; Jing et al 2001a), or the negative slope of the motor readiness potential after M1-stimulation (Rossi et al 2000; Ortu et al 2009).…”

Section: Resultsmentioning

confidence: 99%

“…Only a few studies to date have explored EEG aftereffects with these protocols (TBS: Katayama and Rothwell 2007; Ishikawa et al 2007; Sağlam et al 2008; Schindler et al 2008; Poreisz et al 2008; Ortu et al 2009; Grossheinrich et al 2009; PAS: Tsuji and Rothwell 2002; Wolters et al 2005; Huber et al 2008). In these studies, both TBS and PAS were associated with significant aftereffects of effect-sizes comparable to those found following conventional rTMS (cTBS: mean = 35%, range: 15–50%, n = 6 studies; iTBS: mean = 17.5%, range: 15–20%, n = 3 studies; PAS: mean = 22.5%, range: 10–50%, n = 3 studies; see also Table 1) and provoked either facilitation or suppression (see also Fig.…”

Section: Resultsmentioning

confidence: 99%

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A Review of Combined TMS-EEG Studies to Characterize Lasting Effects of Repetitive TMS and Assess Their Usefulness in Cognitive and Clinical Neuroscience

2009

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Transcranial magnetic stimulation (TMS) has developed into a powerful tool for studying human brain physiology and brain-behavior relations. When applied in sessions of repeated stimulation, TMS can lead to changes in neuronal activity/excitability that outlast the stimulation itself. Such aftereffects are at the heart of the offline TMS protocols in cognitive neuroscience and neurotherapeutics. However, whether these aftereffects are of applied interest critically depends on their magnitude and duration, which should fall within an experimentally or clinically useful range without increasing risks and adverse effects. In this short review, we survey combined TMS-EEG studies to characterize the TMS-aftereffects as revealed by EEG to contribute to the characterization of the most effective and promising repetitive TMS-parameters. With one session of conventional repetitive TMS (of fixed pulse frequency), aftereffects were consistently comparable in magnitude to EEG-changes reported after learning or with fatigue, and were shortlived (<70 min). The few studies using recently developed protocols (such as theta burst stimulation) suggest comparable effect-size but longer effect-durations. Based on the reviewed data, it is expected that TMS-efficacy can be further promoted by repeating TMS-sessions, by using EEG-gated TMS to tailor TMS to current neuronal state, or by other, non-conventional TMS-protocols. Newly emerging developments in offline TMS research for cognitive neuroscience and neurotherapeutics are outlined.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Review of Combined TMS-EEG Studies to Characterize Lasting Effects of Repetitive TMS and Assess Their Usefulness in Cognitive and Clinical Neuroscience

2009

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“…No changes to SEPs were found after M1 stimulation (Katayama & Rothwell, 2007). Ragert et al (Ragert, Franzkowiak, Schwenkreis, Tegenthoff, & Dinse, 2008) used a paired pulse SEP protocol to show reduced paired pulse inhibition in the N20 component for the right but not left hand median nerve after iTBS to left S1 consistent with a facilitory effect.…”

Section: Transcranial Magnetic Stimulation (Tms)mentioning

confidence: 95%

“…To investigate the effects of excitatory iTBS on SEPs, Katayama and Rothwell (2007) administered iTBS to both left M1 and S1 and found facilitation of the N20 and P25/N33 components of SEPs for the right hand median nerve after S1 stimulation, with maximal effects appearing 15 minutes post-stimulation and lasting at least 30 minutes. No changes to SEPs were found after M1 stimulation (Katayama & Rothwell, 2007).…”

Section: Transcranial Magnetic Stimulation (Tms)mentioning

confidence: 99%

Modifying somatosensory processing with non-invasive brain stimulation

Song

Sandrini

Cohen

2011

Restorative Neurology and Neuroscience

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“…It is not clear though whether this dichotomy of effects also applies when rTMS is directed to other cortical areas. At least, low-frequency (1 Hz) rTMS (Enomoto et al, 2001) and intermittent theta-burst stimulation of the somatosensory cortex with the initial phase of current in the brain directed latero-posteriorly (Katayama & Rothwell, 2007) failed to alter median nerve somatosensory evoked potential amplitudes.…”

Section: Pas In the Human Somatosensory Cortexmentioning

confidence: 98%

Homeostatic Metaplasticity in the Human Somatosensory Cortex

Bliem

Müller-Dahlhaus

Dinse

et al. 2008

Journal of Cognitive Neuroscience

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Long-term potentiation (LTP) and long-term depression (LTD) are regulated by homeostatic control mechanisms to maintain synaptic strength in a physiological range. Although homeostatic metaplasticity has been demonstrated in the human motor cortex, little is known to which extent it operates in other cortical areas and how it links to behavior. Here we tested homeostatic interactions between two stimulation protocols -- paired associative stimulation (PAS) followed by peripheral high-frequency stimulation (pHFS) -- on excitability in the human somatosensory cortex and tactile spatial discrimination threshold. PAS employed repeated pairs of electrical stimulation of the right median nerve followed by focal transcranial magnetic stimulation of the left somatosensory cortex at an interstimulus interval of the individual N20 latency minus 15 msec or N20 minus 2.5 msec to induce LTD- or LTP-like plasticity, respectively [Wolters, A., Schmidt, A., Schramm, A., Zeller, D., Naumann, M., Kunesch, E., et al. Timing-dependent plasticity in human primary somatosensory cortex. Journal of Physiology, 565, 1039-1052, 2005]. pHFS always consisted of 20-Hz trains of electrical stimulation of the right median nerve. Excitability in the somatosensory cortex was assessed by median nerve somatosensory evoked cortical potential amplitudes. Tactile spatial discrimination was tested by the grating orientation task. PAS had no significant effect on excitability in the somatosensory cortex or on tactile discrimination. However, the direction of effects induced by subsequent pHFS varied with the preconditioning PAS protocol: After PAS(N20-15), excitability tended to increase and tactile spatial discrimination threshold decreased. After PAS(N20-2.5), excitability decreased and discrimination threshold tended to increase. These interactions demonstrate that homeostatic metaplasticity operates in the human somatosensory cortex, controlling both cortical excitability and somatosensory skill.

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Modulation of somatosensory evoked potentials using transcranial magnetic intermittent theta burst stimulation

Cited by 50 publications

References 16 publications

A Review of Combined TMS-EEG Studies to Characterize Lasting Effects of Repetitive TMS and Assess Their Usefulness in Cognitive and Clinical Neuroscience

A Review of Combined TMS-EEG Studies to Characterize Lasting Effects of Repetitive TMS and Assess Their Usefulness in Cognitive and Clinical Neuroscience

Modifying somatosensory processing with non-invasive brain stimulation

Homeostatic Metaplasticity in the Human Somatosensory Cortex

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