Effect of the type of reducing agents of silver ions in interpolyelectrolyte-metal complexes on the structure, morphology and properties of silver-containing nanocomposites

Demchenko, V.; Riabov, S.V.; Kobylinskyi, S.; Goncharenko, L. A.; Rybalchenko, N.; Kruk, A.S.; Moskalenko, Oleg; Шут, М. І.

doi:10.1038/s41598-020-64079-0

Cited by 27 publications

(17 citation statements)

References 13 publications

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“…In order to obtain a 100 ppm colloidal silver nanoparticle solution, a chemical reduction method was used, derived from the aqueous solution phase route of Zielinska et al [26]. This method involves the reduction of Ag + to Ag 0 , starting from AgNO 3 as silver precursor and a reducing mixture based on the synergistic effect of NaBH 4 and citric acid (biocompatible antioxidant, similar with ascorbic acid, but with a reducing effect known to be lower than that of NaBH 4 [27]). Citrate ions also play the roles of stabilizing and complexing agent, and it is reasonable to assume that silver citrate complexes would act synergistically as antimicrobial agents and antioxidants [28].…”

Section: Agnps Synthesismentioning

confidence: 99%

Collagen-Carboxymethylcellulose Biocomposite Wound-Dressings with Antimicrobial Activity

et al. 2021

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Microbial infections associated with skin diseases are frequently investigated since they impact on the progress of pathology and healing. The present work proposes the development of freeze-dried, glutaraldehyde cross-linked, and non-cross-linked biocomposite dressings with a porous structure, which may assist the reepithelization process through the presence of collagen and carboxymethylcellulose, along with a therapeutic antimicrobial effect, due to silver nanoparticles (AgNPs) addition. Phisyco-chemical characterization revealed the porous morphology of the obtained freeze-dried composites, the presence of high crystalline silver nanoparticles with truncated triangular and polyhedral morphologies, as well as the characteristic absorption bands of collagen, silver, and carboxymethylcellulose. In vitro tests also assessed the stability, functionality, and the degradability rate of the obtained wound-dressings. Antimicrobial assay performed on Gram-negative (Escherichia coli), Gram-positive (Staphyloccocus aureus) bacteria, and yeast (Candida albicans) models demonstrated that composite wound dressings based on collagen, carboxymethylcellulose, and AgNPs are suitable for skin lesions because they prevent the risk of infection and have prospective wound healing capacity. Moreover, the cell toxicity studies proved that the obtained materials can be used in long time treatments, with no cytotoxic effects.

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Section: Agnps Synthesismentioning

confidence: 99%

Collagen-Carboxymethylcellulose Biocomposite Wound-Dressings with Antimicrobial Activity

et al. 2021

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“…Reducing agents for example, NaBH 4 , N 2 H 4 , and C 6 H 8 O 6 effect the structure, morphology, and properties of metal‐containing nanocomposite. NaBH 4 as reducing agent essentially provide the reduced NPs with comparatively smaller crystallite size and enhanced antimicrobial activity as compare to other reducing agents (Demchenko et al, 2020). Following probable reaction steps take place during metal ions reduction in the presence of NaBH 4 in aqueous media (Glavee, Klabunde, Sorensen, & Hadjapanayis, 1992):

{NaBH}_{4} + H_{2} normalO \vec{false} {Na}_{(aq)}^{+} + {BH}_{4_{((), aq)}}^{-} {BH}_{4}^{-} + 2 H_{2} normalO \vec{false} {BO}_{2}^{-} + 4 H_{2}

2 {MX}_{2} + 4 {BH}_{4}^{-} + 9 H_{2} normalO \to M_{2} normalB + 4 X^{-} + 12.5 H_{2} + 3 normalB {(OH)}_{3}

4 M_{2} normalB + 3 O_{2} \to 8 M_{(normals)} + 2 B_{2} O_{3}

B_{2} O_{3} + 3 H_{2} normalO \to 2 normalB {(OH)}_{3}

…”

Section: Resultsmentioning

confidence: 99%

“…SEM was operated at 5.0 kV using JSM6700F microscope. (Demchenko et al, 2020). Following probable reaction steps take place during metal ions reduction in the presence of NaBH 4 in aqueous media (Glavee, Klabunde, Sorensen, & Hadjapanayis, 1992):…”

Section: Characterizationmentioning

confidence: 99%

Synthesis, characterization, and biological screening of metal nanoparticles loaded gum acacia microgels

Ihsan

Ullah

Khan

et al. 2021

Microscopy Res & Technique

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We report novel gum acacia (GA) based microgels composites for multifunctional biomedical application. High yield of spherical GA microgels particles within 5-50 μm size range was obtained via crosslinking the polymer in the reverse micelles of surfactantsodium bis (2-ethylhexyl) sulfosuccinate (NBSS) in gasoline medium. The prepared microgels were then utilized for in situ silver (Ag) and cobalt (Co) nanoparticles (NPs) synthesis to subsequently produce GNAg and GNCo nanocomposite microgels, respectively. Ag and Co NPs of particle of almost less than 40 nm sizes were homogenously distributed over the matrices of the prepared microgels, and therefore, negligible agglomeration effect was observed. Pristine GA microgels, and the nanocomposite microgels were thoroughly characterized through FTIR, DSC, TGA, XRD, SEM, EDS, and TEM. The well-characterized pristine GA microgels and the nanocomposite microgels were then subjected to multiple in vitro bioassays including antioxidant, antidiabetic, and antimicrobial activities as well as biocompatibility investigation. Our results demonstrate that the prepared nanocomposites in particular GNAg microgels exhibited excellent biomedical properties as compared to pristine GA microgels. Among the prepared samples, GNAg nanocomposites were highly active against Fusarium oxysporum and Aspergillus niger that show 47.73% ± 0.25 inhibition and 32.3% ± 2.0 with IC-50 of 220 μg ml −1 and 343 μg ml −1 , respectively. Moderate antidiabetic activity was also observed for GNAg nanocomposites with considerable inhibition of 15.34% ± 0.20 and 14.7% ± 0.44 for both α-glucosidase and α-amylase, respectively. Moreover, excellent antioxidant properties were found for both the GNAg and GNCo nanocomposites as compared to pristine GA microgels. A remarkable biocompatible nature of the nanocomposites in particular GNAg makes the novel GA composites, to be exploited for diverse biomedical applications.

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“…According to the literature analysis, the reduction of Ag + ions in the polymer matrix is one of the promising ways for obtaining silver-containing polymer nanocomposites, which allows for controlling the size and morphology of nanoparticles [16]. The most common methods of reduction are chemical [17], thermochemical [18], radiation-chemical [19], and the use of plant extracts for reduction [20].…”

Section: Introductionmentioning

confidence: 99%

Structure-Morphology-Antimicrobial and Antiviral Activity Relationship in Silver-Containing Nanocomposites Based on Polylactide

et al. 2022

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Green synthesis of silver-containing nanocomposites based on polylactide (PLA) was carried out in two ways. With the use of green tea extract, Ag+ ions were reduced to silver nanoparticles with their subsequent introduction into the PLA (mechanical method) and Ag+ ions were reduced in the polymer matrix of PLA-AgPalmitate (PLA-AgPalm) (in situ method). Structure, morphology and thermophysical properties of nanocomposites PLA-Ag were studied by FTIR spectroscopy, wide-angle X-ray scattering (WAXS), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) methods. The antimicrobial, antiviral, and cytotoxic properties were studied as well. It was found that the mechanical method provides the average size of silver nanoparticles in the PLA of about 16 nm, while in the formation of samples by the in situ method their average size was 3.7 nm. The strong influence of smaller silver nanoparticles (3.7 nm) on the properties of nanocomposites was revealed, as with increasing nanosilver concentration the heat resistance and glass transition temperature of the samples decreases, while the influence of larger particles (16 nm) on these parameters was not detected. It was shown that silver-containing nanocomposites formed in situ demonstrate antimicrobial activity against gram-positive bacterium S. aureus, gram-negative bacteria E. coli, P. aeruginosa, and the fungal pathogen of C. albicans, and the activity of the samples increases with increasing nanoparticle concentration. Silver-containing nanocomposites formed by the mechanical method have not shown antimicrobial activity. The relative antiviral activity of nanocomposites obtained by two methods against influenza A virus, and adenovirus serotype 2 was also revealed. The obtained nanocomposites were not-cytotoxic, and they did not inhibit the viability of MDCK or Hep-2 cell cultures.

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Effect of the type of reducing agents of silver ions in interpolyelectrolyte-metal complexes on the structure, morphology and properties of silver-containing nanocomposites

Cited by 27 publications

References 13 publications

Collagen-Carboxymethylcellulose Biocomposite Wound-Dressings with Antimicrobial Activity

Collagen-Carboxymethylcellulose Biocomposite Wound-Dressings with Antimicrobial Activity

Synthesis, characterization, and biological screening of metal nanoparticles loaded gum acacia microgels

Structure-Morphology-Antimicrobial and Antiviral Activity Relationship in Silver-Containing Nanocomposites Based on Polylactide

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