Effect of the platelet-rich plasma covering of polypropylene mesh on oxidative stress, inflammation, and adhesions

Belebecha, Vanessa; Casagrande, Rúbia; Urbano, Mariana Ragassi; Crespigio, Jefferson; Martínez, Renata M.; Vale, David L.; Almeida, Silvio Henrique Maia de

doi:10.1007/s00192-019-03938-5

Cited by 17 publications

(10 citation statements)

References 30 publications

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“…28 On the contrary, Belebecha et al found reduced levels of myeloperoxidase and N-acetylglucosamide activities as well as decreased oxidative stress and elevated antioxidant levels without difference in inflammatory cells in the specimen of rabbits with PRP-coated polypropylene mesh compared to those with uncoated polypropylene mesh. 29 Finally, an in vitro study by Medel et al demonstrated the beneficial effect of PRP in enhancing the cell attachment to the surface of both Vicryl and Restorelle meshes compared to no PRP-coated meshes as proved by light microscopic evaluation (9875 ± 996 vs 1006 ± 84 cells/cm 2 , 9.8 times increase and 3724 ± 407 vs 649 ± 53 cells/cm 2 , 5.7 times increase, respectively). 30 Thus, the application of PRP could lead to decreased complications related to meshes through the potential effect of PRP to enhance attachment of meshes to adjacent tissues.…”

Section: Resultsmentioning

confidence: 95%

The Emerging Role on the Use of Platelet-Rich Plasma Products in the Management of Urogynaecological Disorders

et al. 2021

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Background: The regenerative efficacy of platelet-derived products has been recently investigated in the treatment of pelvic floor disorders (PFDs). We aimed to synthesize the current evidence of platelet-rich plasma (PRP) products used in urogynaecological disorders including vaginal atrophy, pelvic organ prolapse (POP), urinary incontinence, vaginal fistulas and vaginal mesh exposure. Methods: A meticulous search of the currently available literature on the use of PRP for the management of PFDs was performed using 3 electronic databases. Results: PRP could be a feasible alternative modality for the management of vaginal atrophy with favourable outcomes in vaginal atrophy parameters and patients’ satisfaction, especially when hormone therapy is contraindicated. In patients with POP, an increase in collagen concentration after PRP application was observed while the use of PRP resulted in improvement of stress urinary incontinence symptoms. A considerable proportion of vesicovaginal fistulas were treated after application of PRP-based injections. Conclusions: There is only limited evidence of the use of PRP for PFDs. Platelet-rich plasma appears to be a promising, easy to apply, cost-effective and feasible alternative therapeutic modality for the management of various urogynaecological disorders. Future randomized trials are needed to confirm the efficacy of PRP in the treatment of urogynaecological disorders.

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Section: Resultsmentioning

confidence: 95%

The Emerging Role on the Use of Platelet-Rich Plasma Products in the Management of Urogynaecological Disorders

et al. 2021

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“…A myriad of coating strategies has been adopted for developing an antifouling PP mesh, including natural biomaterials and hydrophilic synthetic polymer modifications. The former includes extracellular matrix , and proteins abstracted from various tissues, − whose hydrophilicity helps provide the antifouling ability to some degree. The biochemical or biomechanical signals in their composition or structure are more important in anti-inflammatory mechanisms because they mediate immune cell behaviors .…”

Section: Introductionmentioning

confidence: 99%

Synergistic Anti-inflammatory Coating “Zipped Up” on Polypropylene Hernia Mesh

Qiao

Zhang

Wang

et al. 2021

ACS Appl. Mater. Interfaces

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Violent inflammation has impeded worry-free application of polypropylene (PP) hernia meshes. Efficient antiinflammatory coatings are urgently needed to alter the situation. Here, we present a zipper-like, two-layer coating with an intermediate antioxidant layer (I) and an outer antifouling layer (II) to endow PP meshes with synergistic anti-inflammatory effects. The controllable antioxidant ability of layer I was obtained by modulating the assembly cycle of the metal-phenolic network (MPN) composed of tannic acid (TA) and Fe 3+ . Polyzwitterionic (PMAD) brush-based layer II was generated upon multiple interactions between the catechol side groups of PMAD and layer I. To consolidate the entire assembly architecture, aryloxy radical coupling was initiated through alkali-catalyzed oxidation. The reaction is similar to a "zipping up" process to construct covalent bonds in the I−II interface and layer I by coupling adjacent catechol groups, which facilely achieved grafting and crosslinking. The obtained coating (PMAD-TA/Fe) did not affect the original properties of the PP mesh and remained stable during cyclic tensile testing or degradation. Most importantly, the excellent antioxidant and antifouling capacities enabled PMAD-TA/Fe-PP to exhibit desirable anti-inflammatory effects and reduce collagen deposition when compared with the bare material. The synergistic anti-inflammatory coating eliminates a major hindrance in the design of biocompatible meshes, and its potential application in developing medical implants with low immunogenicity is promising.

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“…A large number of studies have proved that PRP can promote the regeneration of cartilage and bone tissue, as well as anti-inflammatory and antibacterial effects [ 28 ]. In recent years, it has been widely used in bone and soft tissue reconstruction surgery, plastic surgery, diabetic foot refractory ulcers, and chronic skin ulcers [ 29 ]. Yifu is a kind of recombinant human epidermal growth factor for external use.…”

Section: Discussionmentioning

confidence: 99%

Effect and Safety Analysis of PRP and Yifu Combined with Ultrapulsed CO2 Lattice Laser in Patients with Sunken Acne Scar

Wang

Wang²,

Zhang

et al. 2022

Journal of Healthcare Engineering

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Objective. To investigate the effect and safety of PRP and Yifu combined with ultrapulsed CO2 lattice laser in patients with sunken acne scar. Methods. 700 subjects were selected from the group of patients with sunken acne scar treated in our hospital from November 2010 to December 2020. They were divided into control group (n = 350) and study group (n = 350). The grouping was mainly based on the random number table method. Patients in the control group were treated with ultrapulse CO2 lattice laser, while those in the study group were treated with ultrapulse CO2 lattice laser combined with PRP and Yifu. The clinical effect, scar improvement and quality of life before and after treatment, and adverse events during treatment were compared between the two groups. The clinical effect was categorized into cure after treatment, significant effect, effective, and ineffective. The total effective rate = 1 − ineffective rate. Results. After treatment, the total effective rate of the study group (81.43%) was higher than that of the control group (70.00%). After treatment, ECCA, VSS scores, daily activities, symptoms and feelings, work and study, leisure and entertainment, interpersonal relationship, treatment status, and total scores were all lower in both groups than before treatment, and the study group was lower than the control group. During the treatment, the incidence of adverse events in the study group (17.33%) was lower than that in the control group (28.57%), P < 0.05 . Conclusion. PRP and Yifu combined with ultrapulse CO2 lattice laser in the treatment of sunken acne scar can effectively improve the scar, reduce the incidence of adverse events, and the treatment effect is obvious, which can improve the quality of life of the patients.

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Effect of the platelet-rich plasma covering of polypropylene mesh on oxidative stress, inflammation, and adhesions

Cited by 17 publications

References 30 publications

The Emerging Role on the Use of Platelet-Rich Plasma Products in the Management of Urogynaecological Disorders

The Emerging Role on the Use of Platelet-Rich Plasma Products in the Management of Urogynaecological Disorders

Synergistic Anti-inflammatory Coating “Zipped Up” on Polypropylene Hernia Mesh

Effect and Safety Analysis of PRP and Yifu Combined with Ultrapulsed CO2 Lattice Laser in Patients with Sunken Acne Scar

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