Effect of the phytotherapeutic agent Eviprostat® on 17β‐estradiol‐induced nonbacterial inflammation in the rat prostate

Abstract

Eviprostat, which has effective antioxidant and anti-inflammatory activities in the prostate, may be useful for the clinical treatment of chronic prostatitis. These activities of Eviprostat may also contribute to the amelioration of prostate inflammation in BPH patients. Prostate 69: 1404-1410, 2009. (c) 2009 Wiley-Liss, Inc.

Suppression of bladder overactivity and oxidative stress by the phytotherapeutic agent, Eviprostat, in a rat model of atherosclerosis‐induced chronic bladder ischemia

“…The daily dose of 36 mg/kg Eviprostat produced a downregulation of bladder pro‐inflammatory cytokines, as well as a reduction in oxidative‐stress markers in both AI rats (in the present study) and BOO rats 15 . We have reported that Eviprostat ameliorates carrageenin‐induced paw edema, 14 and reduces oxidative stress and inflammation in the prostate 26,27 . In a clinical study, 18 patients who received daily oral Eviprostat for 4 weeks showed considerably lower urinary oxidative stress marker levels than before treatment.…”

567 Eviprostat has an identical effect compared to pollen extract (Cernilton) in patients with chronic prostatitis/chronic pelvic pain syndrome: A randomized, prospective study

“…Eviprostat is a phytotherapeutic agent commonly used to treat prostatic hypertrophy in Japan [13][14][15]. An experiment using nonbacterial prostatitis model suggested that Evoprostat is potentially effective for the treatment of CP/CPPS.…”

“…Oka et al administered Eviprostat treatment in a rat model of nonbacterial prostatitis and reported that oxidative stress and proinflammatory cytokines in the enlarged prostate were considerably suppressed, and that Eviprostat may be useful in the clinical treatment of CP/ CPPS [13][14][15]. Here we conducted a randomized prospective study to determine the effectiveness and safety of Eviprostat to treat CP/CPPS in comparison with pollen extract.…”

“…Eviprostat is a phytotherapeutic agent widely used in the treatment of prostatic hypertrophy and has been used in Japan and Germany for more than 40 years [13][14][15]. Eviprostat consists of five components: four are extracted from the umbellate wintergreen Chimaphila umbellata, the aspen Populus tremula, the small pasque flower Pulsatilla pratensis, and the field horsetail Equisetum arvense, and the fifth is germ oil from wheat (Tritium aestivum) [13][14][15].…”

“…Eviprostat consists of five components: four are extracted from the umbellate wintergreen Chimaphila umbellata, the aspen Populus tremula, the small pasque flower Pulsatilla pratensis, and the field horsetail Equisetum arvense, and the fifth is germ oil from wheat (Tritium aestivum) [13][14][15].…”