Suppression of bladder overactivity and oxidative stress by the phytotherapeutic agent, Eviprostat, in a rat model of atherosclerosis‐induced chronic bladder ischemia

Matsui, Takahiro; Oka, Michiko; Fukui, Tomijiro; Tanaka, Mitsushi; Oyama, Tatsuya; Sagawa, Koji; Nomiya, Masanori; Yamaguchi, Osamu

doi:10.1111/j.1442-2042.2012.03000.x

Cited by 24 publications

(29 citation statements)

References 24 publications

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“…Excess production of ROS might be involved in the development of overactive bladder, including ischemia/reperfusion and aging . Protamine sulfate is known to affect the bladder permeability barrier and to damage the urothelial cell surface, which increases lipid peroxidation from free radicals and results in oxidative injury .…”

Section: Discussionmentioning

confidence: 99%

Anti‐oxidant activity and attenuation of bladder hyperactivity by the flavonoid compound kaempferol

et al. 2013

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Abbreviations & AcronymsObjectives: To evaluate the anti-oxidant activity of the flavonoid compound, kaempferol, and to examine its role in the suppression of oxidative stress and attenuation of bladder hyperactivity in a rat model of bladder injury. Methods: The anti-oxidative activity of kaempferol was examined in lipopolysaccharidetreated RAW264.7 macrophages by using flow cytometry. For in vivo studies, rats were pretreated with kaempferol or vehicle for 24 h. The rat urothelium was injured by the administration of protamine sulfate for 1.5 h and irritated by the subsequent infusion of potassium chloride for 4 h. Oxidative stress in the bladder tissue was assessed using chemiluminescence assay, and the bladder pressure was determination by cystomertrogram. Results: Kaempferol significantly suppressed lipopolysaccharide-induced reactive oxygen species production in RAW264.7 rat macrophages. Exposure of the rat bladder to sequential infusion of protamine sulfate and potassium chloride induced bladder hyperactivity. Pretreatment with kaempferol, prevented the formation of reactive oxygen species and prolonged the intercontraction interval. Conclusion: Kaempferol suppresses oxidative stress and attenuates bladder hyperactivity caused by potassium chloride after protamine sulfate-induced bladder injury.

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Section: Discussionmentioning

confidence: 99%

Anti‐oxidant activity and attenuation of bladder hyperactivity by the flavonoid compound kaempferol

et al. 2013

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“…Eviprostat [61] , Coenzyme Q10 [62,63] and melatonin [64] were found to reverse several bladder functional injuries caused by bladder ischemia, contributing to strengthen the oxidative/pro-inflammatory theory behind a decreased bladder blood flow. Finally, stem cell therapy is also making its entry in the field of the ischemia-induced bladder dysfunction.…”

Section: Treatment Of Ischemic Oabmentioning

confidence: 90%

“…Several studies suggested the effective role of anti-oxidant agents in the protectiveness and reversal of bladder ischemia lesions [61][62][63][64] . Eviprostat [61] , Coenzyme Q10 [62,63] and melatonin [64] were found to reverse several bladder functional injuries caused by bladder ischemia, contributing to strengthen the oxidative/pro-inflammatory theory behind a decreased bladder blood flow.…”

Section: Treatment Of Ischemic Oabmentioning

confidence: 99%

Lower Urinary Tract Symptoms and Aging: The Impact of Chronic Bladder Ischemia on Overactive Bladder Syndrome

Camões

Coelho²,

Castro-Díaz

et al. 2015

Urol Int

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Introduction: The overactive bladder syndrome (OAB) is one of the most common and bothersome subsets of lower urinary tract symptoms (LUTS), affecting predominantly the aged population, with a worldwide distribution. This syndrome has not been completely understood, yet the aging process and the decreased blood flow to the bladder have been highlighted as closely related to this phenomenon. Materials and Methods: We performed a search on the online database PubMed/MEDLINE with the following MESH terms: ‘Overactive Bladder AND (Ischemia OR Aging OR Vascular Disease)'. We considered manuscripts written in English and published in the last 10 years (2004-2014, October). Additional manuscripts, such as referenced by reviews, were further included. Results: The aging process and the structural and functional changes resulting from an ischemic process emerge as important features that contribute to OAB. The ischemic-induced molecular and structural modifications that occur in the bladder have only recently been the objective of thorough studies, which link cardiovascular risk factors, vascular lesions and OAB. New animal models are being created to test new areas of treatment or prevention of ischemic-induced bladder dysfunction. Conclusion: Recent data point out that several physiological and pathological modifications that occur in the bladder associated with OAB and aging are closely related to ischemia.

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“…The rats were raised for 21 consecutive days for successful establishment of the models (Lin et al, 2012;Matsui et al, 2012).…”

Section: Establishment Of Atherosclerosis Modelsmentioning

confidence: 99%

Effect of GBOT on blood lipid and blood glucose metabolism in rats with atherosclerosis

2015

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ABSTRACT. We observed the variation in in vivo blood lipid and blood glucose metabolism in rats with atherosclerosis after 5-(3,4-dihydroxyphenyl)-1-piperidin-1-yl-penta-2,4-dien-1-one (GBOT) administration. Wistar rats aged 10 weeks received a high-fat diet to establish the atherosclerosis model. Metabolic indices related to blood lipid and blood glucose were measured before modeling and at 4 and 8 weeks after modeling. Liver fat levels in rats were measured at 8 weeks to analyze the relationship between liver fat and blood lipid levels. We examined the mechanism of blood lipid reduction. The levels of serum triglycerides, total cholesterol, and very-low-density lipoprotein cholesterol in rats in the control group were significantly decreased (P < 0.05) compared with those in the 4-week control group at 4 weeks and decreased significantly and continuously until the 8th week (P < 0.05). Compared with the 8-week control group, the blood glucose level in rats in the 8-week experimental group decreased significantly (P < 0.05), and the level of insulin sensitivity index decreased significantly (P < 0.05). Compared with the control group, triglyceride and total cholesterol levels per unit mass in rat liver tissue in the 8-week experimental group decreased significantly (P < 0.05). Western blotting indicated that GBOT significantly increased the expression of lecithin-cholesterol acyltransferase, low-density lipoprotein receptor, and cholesterol 7 alpha-hydroxylase proteins. GBOT can significantly decrease the levels of blood lipid and blood glucose in rat models of atherosclerosis, and its mechanism may be associated with the promotion of expression of lecithin-cholesterol acyltransferase, low-density lipoprotein receptor, and cholesterol 7 alpha-hydroxylase proteins.

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Suppression of bladder overactivity and oxidative stress by the phytotherapeutic agent, Eviprostat, in a rat model of atherosclerosis‐induced chronic bladder ischemia

Cited by 24 publications

References 24 publications

Anti‐oxidant activity and attenuation of bladder hyperactivity by the flavonoid compound kaempferol

Anti‐oxidant activity and attenuation of bladder hyperactivity by the flavonoid compound kaempferol

Lower Urinary Tract Symptoms and Aging: The Impact of Chronic Bladder Ischemia on Overactive Bladder Syndrome

Effect of GBOT on blood lipid and blood glucose metabolism in rats with atherosclerosis

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