Effect of the FGF2 SNP11646 on milk production and fertility traits of Holstein cattle

Brzáková, Michaela; Hosnedlová, Božena; Svitáková, Alena; Vernerová, Kateřina; Veselá, Zdenka; Čítek, J.

doi:10.17221/61/2015-cjas

Cited by 3 publications

(2 citation statements)

References 26 publications

(28 reference statements)

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“…Li et al [47] have shown that the SNP rs210169303 was linked to the highest 305-day milk yield. Brzáková et al [48] assessed the effect of SNP11646 in the FGF2 gene on the regressive evidence of the breeding value of sires in terms of reproductive qualities and milk production. The difference in milk production in animals with different genotypes was negligible.…”

Section: Candidate Genes With Predicted Functionsmentioning

confidence: 99%

Overview of SNPs Associated with Trans Fat Content in Cow’s Milk

2023

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Lipids consumed with milk derivatives are one of the main parts of the human diet. Trans fatty acids in milk are causing a debate about their impact on the incidence of cardiovascular disease, pathological abnormalities, and cancer. The fatty acid profile of milk is influenced by a large number of different factors, one of which is genetic. The development of genetic studies, including Genome-Wide Association Studies (GWAS), may help define genomic regions associated with fatty acid content in milk, including trans fatty acids. This article provides an overview of international studies on the identification of genomic regions and SNPs associated with the trans fatty acids in cow’s milk. The results are based on research of cattle such as Norwegian Red cattle, Holstein, Jersey, and Brown Swiss. The presented review shows that 68 SNPs were localized on chromosomes 1, 2, 4–6, 8–10, 12, 14–20, 22–25, and 27–29. Further research in this direction will provide new information that will serve as an impetus for the creation of modern breeding technologies and increase the performance of the manufacture of high-quality dairy products. The search for genetic markers associated with the content of TFA in milk is a promising direction in agricultural science and will allow more complete breeding work with cattle.

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Section: Candidate Genes With Predicted Functionsmentioning

confidence: 99%

Overview of SNPs Associated with Trans Fat Content in Cow’s Milk

2023

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“…Частота аллелей A и G в чешской популяции голштинского скота составила 0,35 и 0,65, а частоты генотипов -0,13; 0,43 и 0,43 % для генотипов AA, AG и GG соответственно [3].…”

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Polymorphism of the fibroblast growth factor 2 gene (FGF 2) in Holstein cattle in the conditions of the Republic of Tatarstan

Mukhanina,

Safina,

Fattakhova

et al. 2023

asj

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The basic fibroblast growth factor is a signaling protein encoded by the FGF2 gene. The FGF2 gene is expressed by the endometrium of cattle and is an important factor contributing to the preservation of pregnancy in ruminants, regulates the expression of interferon-? (IFNT), which is involved in the production of milk. The aim of the work is to identify the polymorphism of the FGF2 gene (SNP11646 A ? G substitution) in intron 1 in the Tatarstan population of Holstein cows. 270 Holstein dairy cows were genotyped by PCR-RFLP. As a result of identification, three genotypes were identified: AA – 19.6%, AG – 42.6 and GG – 37.8 %, and the observed distribution of alleles A – 0.409 and G – 0.591. The population is in genetic equilibrium balance, but there is a shift an increase towards heterozygosity of individuals.

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The effect of the gene of the main fibroblast growth factor (FGF2) on the dairy productivity of Holstein cattle

Mukhanina,

Safina,

Shakirov

et al. 2023

jour

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The effect of polymorphism of the gene of the basic fibroblast growth factor (SNP11646 A/G) on the milk production of Holstein cows in the conditions of the Republic of Tatarstan was studied. The DNA of 270 full–aged cows was genotyped by PCR - PDRF. As a result, two FGFA – 0,591 and FGFG – 0,409 alleles were identified; and three FGFAA genotypes – 19,6% (53 goals) and FGFAG – 42,6% (115 goals), FGFGG – 37,8% (102 goals). The highest milk yield for full lactation and for 305 days of lactation, a high coefficient of lactation was noted in individuals with the genotype FGF2AG. The best milk quality indicators (high protein content, fewer somatic cells) were found in animals homozygous for the A allele. All cows have a high stable and smoothly decreasing lactation curve, the coefficient of lactation stability is higher for the GG genotype.

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Effect of the FGF2 SNP11646 on milk production and fertility traits of Holstein cattle

Cited by 3 publications

References 26 publications

Overview of SNPs Associated with Trans Fat Content in Cow’s Milk

Overview of SNPs Associated with Trans Fat Content in Cow’s Milk

Polymorphism of the fibroblast growth factor 2 gene (FGF 2) in Holstein cattle in the conditions of the Republic of Tatarstan

The effect of the gene of the main fibroblast growth factor (FGF2) on the dairy productivity of Holstein cattle

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