Effect of the Concentration of NaBH4 and N2H4 as Reductant Agent on the Synthesis of Copper Oxide Nanoparticles and its Potential Antimicrobial Applications

Abstract

The antibacterial activity of various nanoparticles is gaining increasing interest due to its potential medical applications. In this work, we presented the synthesis of copper oxide nanoparticles prepared by chemical reduction from aqueous solutions of copper sulfate (CuSO 4) with sodium borohydride (NaBH 4) and hydrazine hydrate (N 2 H 4) as reductant and polyvinylpyrrolidone (PVP) as stabilizer. The X-ray diffraction spectra showed the formation of tenorite (CuO) and cuprite (Cu 2 O) nanoparticles when different ratios of CuSO 4 /NaBH 4 and CuSO 4 /N 2 H 4 were used. Photographs obtained by transmission electron microscopy (TEM) showed agglomerates of grains with a narrow size distribution (from 20 to 70 nm), whereas the radii of the individual particles were between 2 and 20 nm. Smaller nanoparticles and narrower particle size distributions were obtained when NaBH 4 was used. The results of antibacterial activity using the Kirby-Bauer method showed that nanoparticles obtained with NaBH 4 presented a reasonable bactericidal activity. Pseudomonas aureginosa and Staphylococcus aureus were more susceptible to the particle size than Escherichia coli. In addition, with small amounts of Cu 2 O in samples of CuO nanoparticles, the antibacterial susceptibility against Pseudomonas aureginosa was improved. Finally, nanoparticles of CuO incorporated into cotton by applying ultrasound waves remained impregnated after five washes.

Antibacterial Behavior of Laser-Ablated Copper Nanoparticles

“…Sliver-containing materials can be used in vascular grafts, to reduce infection, as dental materials as well as to inhibit the bacterial colonization [16]. Gold nanoparticles are used for drug delivery purposes [17,18]. Metallic nanoparticles play a crucial role in inhibiting the growth of bacteria in solid and aqueous media due to their large surface-to-volume ratio.…”

Preparation and characterisation of silk fibroin–silver nanoparticles (SF–AgNPs) composite films

“…More recently, many researchers studied the bio or green synthesis of AgNPs. 1,[12][13][14][15] In the present work, we introduced a simple, effective and environmentally friendly method for in situ preparation of AgNPs using bio-based silk fibroin (SF) as a reducing agent at room temperature under light exposure environment. The SF extracted from Bombyx mori silk, a protein polymer, which is naturally abundant, non-toxic and biocompatible material, is introduced for AgNPs synthesis.…”

RETRACTED ARTICLE: Biosynthesis of colloidal silver nanoparticles: Their characterization and potential antibacterial activity

“…More recently many researchers have demonstrated the bio or green route synthesis of silver nanoparticles. [12][13][14][15][16][17][18][19][20] As a result of the growing success and simple process for the nanoparticles formation, bio based methods in this field are swiftly gaining importance. Green synthesis of silver nanoparticles is mainly concerned with the selection of solvent medium, reducing agent, and nontoxic substances for stability.…”