Effect of the Capsicoside G‐rich Fraction from Pepper (Capsicum annuum L.) Seeds on High‐fat Diet‐induced Obesity in Mice

Abstract

Obesity is one of the most common metabolic syndromes and is a major threat to human health worldwide. Given the size of this problem, there is growing interest in natural agents that may decrease obesity. In this study, we investigated the anti-obesity effect of a capsicoside G-rich fraction (CRF; 13.35% capsicoside G) isolated from pepper seeds in diet-induced obese mice. C57BL/6J mice were fed either a normal diet or a high-fat diet (HFD), with or without CRF (HFD + CRF; 10 and 100 mg/kg body weight). The body weight and food efficiency ratio of mice fed HFD + CRF were lower in comparison to that of mice fed only an HFD. Epididymal adipose tissue weight and adipocyte hypertrophy were significantly lower in HFD + CRF mice than in HFD mice. The fat deposition in the liver of mice fed HFD + CRF was lower compared to that of mice fed only an HFD. CRF significantly reversed the HFD-induced elevation of the expression of key adipocyte differentiation regulators, including peroxisome proliferator-activated receptor γ, CCAAT/enhancer-binding protein α, sterol regulatory element binding protein 1c, and their target genes. These results suggest that CRF could be used as dietary therapy for the prevention of obesity and obesity-related metabolic diseases. Copyright © 2016 John Wiley & Sons, Ltd.

Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice

“…ESEE also suppressed weight increases of eWAT, and of organs including the liver, spleen and kidneys versus HFd-fed mice. These findings are in accordance with those of a previous study, in which a capsicoside G-rich fraction from pepper exhibited anti-obesity effects in HFd-induced obese mice (23).…”

“…The induction of obesity in animals via HFd supplementation is the most popular means of mimicking obesity in human, and a number of studies have been conducted using HFd-induced obese mouse models, in which HFd supplementation increases abdominal fat and body weights (22). Previous studies have reported crude plant extracts and natural compounds isolated from them induce weight loss and prevent diet-induced obesity (17,23). Although, E. supina is known to have potent anti-oxidant, anti-aging and anti-cancer effects, its effects on obesity have not been previously studied.…”

Capsinoids Supplementation does not Prevent Weight Gain and does not Change Lipid Profile in Wistar Rats Fed a High-Fat Diet

“…During the feeding period, food intake was higher in the SD than in the HFD groups. Similar food behavior was demonstrated previously [19]. This result can be attributed to high caloric density of HFD in comparison to SD.…”

“…It was observed in previous studies that HFD compared to SD group, exhibited markedly higher body weight and capsinoids could prevent huge body weight gain [19]. These results were controversial in our study, because HFD and HFDC groups presented less weight gain when compared to SD and SDC respectively.…”

“…Regarding organs weight, we observed a slight decrease in epididymal fat pad on HDFC (approximately 30%), but without statistical significance. Sung, Jeong and Lee [19] provided HFD associated with Capsicum annuum L. supplementation (10 or 100 mg/kg doses) for 7 weeks in mice. It was noted that epididymal fat pad was significantly lower in HFD with capsinoids as compared to mice without supplementation.…”