Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice

Nepali, Sarmila; Kim, Do‐Kuk; Lee, Hoon-Yeon; Ki, Hyeon-Hui; Kim, Bo‐Ram; Hwang, Sungwoo; Park, Min; Kim, Dae‐Ki; Lee, Young‐Mi

doi:10.3892/ijmm.2018.3495

Cited by 3 publications

(1 citation statement)

References 41 publications

(43 reference statements)

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“…The following groups were studied for 8 weeks: ND group; HFD group; AME:AVE (3:1) 37.5 group (highfat diet + AME:AVE (3:1) 37.5 mg/kg); AME:AVE (3:1) 75 group (high-fat diet + AME:AVE (3:1) 75 mg/kg); AME:AVE (3:1) 150 group (high-fat diet + AME:AVE (3:1) 150 mg/kg). Another HFD group received oral administration of 150 mg/kg of Garcinia cambogia extract (G 150) daily as a positive control group because of the weight loss effects of Garcinia cambogia extract [46][47][48].…”

Section: Animals and Dietsmentioning

confidence: 99%

Anti-Obesity Effects of a Mixture of Atractylodes macrocephala and Amomum villosum Extracts on 3T3-L1 Adipocytes and High-Fat Diet-Induced Obesity in Mice

Kim¹,

Lee²,

Min³

et al. 2022

Molecules

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Since the potential of (3:1) mixtures of Atractylodes macrocephala and Amomum villosum extracts has been proposed in the management of obesity, the purpose of present study was to investigate the effects of AME:AVE (3:1) mixture on weight loss, obesity-related biochemical parameters, adipogenesis and lipogenesis related proteins in 3T3-L1 cells and HFD-induced obesity in a mouse model. Treatment with AME:AVE (3:1) mixture inhibited lipid accumulation. Furthermore, the treatment with 75 and 150 mg/kg of AME:AVE (3:1) significantly decreased the body weight gain, white adipose tissue (WAT) weight, and plasma glucose level in HFD-induced obese mice. Moreover, treatment with 75 and 150 mg/kg AME:AVE (3:1) also significantly lowered the size of adipocytes in adipose tissue and reduced the lipid accumulation in liver. AME:AVE (3:1) treatment significantly decreased the expression of proteins related to adipogenesis and lipogenesis in 3T3-L1 adipocytes and WAT of HFD-induced obese mice. These results suggest that the AME:AVE herbal mixture (3:1) has anti-obesity effects, which may be elicited by regulating the expression of adipogenesis and lipogenesis-related proteins in adipocytes and WAT in HFD-induced obesity in mice.

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Section: Animals and Dietsmentioning

confidence: 99%

Anti-Obesity Effects of a Mixture of Atractylodes macrocephala and Amomum villosum Extracts on 3T3-L1 Adipocytes and High-Fat Diet-Induced Obesity in Mice

Kim¹,

Lee²,

Min³

et al. 2022

Molecules

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Targeting Nanotechnology and Nutraceuticals in Obesity: An Updated Approach

Behl

Singh

Sharma

et al. 2022

CPD

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Hypothesis: This review article represents a brief layout of the risk factors and pathophysiology responsible for obesity, customary treatment strategies, and nanotechnology-based nutraceutical for therapeutics of obesity. Experiments: An exhaustive search of the literature was done for this purpose, using Google Scholar, PubMed, and ScienceDirect databases. A study of the literature was conducted using publications published in peer-reviewed journals between the years 2000 and 2022. Findings: This was revealed that risk factors responsible for obesity were genetic abnormalities, environmental, and socio-economic factors. Number of research articles published between 2000 and 2022 were based on phytoconstituents based nanoformulation for obesity therapeutics and therefore, have been systematically compiled in this review. Various nutraceuticals like Garcinia cambogia, quercetin, resveratrol, capsaicin, Capsicum, Curcuma longa, Camella Sinensis, Zingiber officinalis, Citrus aurantium, Aegle marmelos, Coffea canephora, Asparagus officinalis, Gardenia jasminoides, Catha edulis, Clusia nemroisa, Rosmarinus officinalis, Cirsium setidens, Betula platyphylla, Tripterygium wilfordi possessing anti-obesity actions are discussed in this review along with their patents, clinical trials as well as their nanoformulation available. Conclusion: This review illustrates that the nanotechnology have a great propensity to impart promising role in the delivery of phytochemicals and nutraceuticals in management of obesity conditions and other related disorders.

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A Comprehensive Review on Anti-obesity Potential of Medicinal Plants and their Bioactive Compounds

Verma

Joshi²,

Bairy

2022

CTM

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Background: Obesity is a complex health and global epidemic issue. It is an increasing global health challenge covering significant social and economic costs. Abnormal accumulation of fat in the body may increase the health risks including diabetes, hypertension, osteoarthritis, sleep apnea, cardiovascular diseases, stroke and cancer. Synthetic drugs available on the market reported to have several side effects. Therefore, the management of obesity got to involve the traditional use of medicinal plants which helps to search the new therapeutic targets and supports the research and development of anti-obesity drugs. Objective: This review aim to update the data and provide a comprehensive report of currently available knowledge of medicinal plants and phyto-chemical constituents reported for their anti-obesity activity. Methodology: An electronic search of the periodical databases like Web of Science, Scopus, PubMed, Scielo, Niscair, ScienceDirect, Springerlink, Wiley, SciFinder and Google Scholar with information reported the period 1991-2019, was used to retrieve published data. Results: A comprehensive report of the present review manuscript is an attempt to list the medicinal plants with anti-obesity activity. The review focused on plant extracts, isolated chemical compounds with their mechanism of action and their preclinical experimental model, clinical studies for further scientific research. Conclusion: This review is the compilation of the medicinal plants and their constituents reported for the managements of obesity. The data will fascinate the researcher to initiate further research that may lead to the drug for the management of obesity and their associated secondary complications. Several herbal plants and their respective lead constituents were also screened by preclinical In-vitro and In-vivo, clinical trials and are effective in the treatment of obesity. Therefore, there is a need to develop and screen large number of plant extracts and this approach can surely be a driving force for the discovery of anti-obesity drugs from medicinal plants.

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Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice

Cited by 3 publications

References 41 publications

Anti-Obesity Effects of a Mixture of Atractylodes macrocephala and Amomum villosum Extracts on 3T3-L1 Adipocytes and High-Fat Diet-Induced Obesity in Mice

Anti-Obesity Effects of a Mixture of Atractylodes macrocephala and Amomum villosum Extracts on 3T3-L1 Adipocytes and High-Fat Diet-Induced Obesity in Mice

Targeting Nanotechnology and Nutraceuticals in Obesity: An Updated Approach

A Comprehensive Review on Anti-obesity Potential of Medicinal Plants and their Bioactive Compounds

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