Effect of temperature on percutaneous absorption of terodiline, and relationship between penetration and fluidity of the stratum corneum lipids

Ogiso, Taro; Hirota, Tsuyoshi; Iwaki, Masahiro; Hino, Takaharu; Tanino, Tadatoshi

doi:10.1016/s0378-5173(98)00309-3

Cited by 39 publications

(22 citation statements)

References 24 publications

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“…The heat-enhanced effect was attributed to both an increase in drug diffusion in the dosage form (vehicle) and skin, with the latter attributed to an increase in skin lipid fluidity (Ogiso et al 1998). Under in vivo conditions, the increase in blood supply to the surface of the skin as a result of increased temperature also plays an important role in enhancing the transdermal delivery of a topically applied compound (Klemsdal, Gjesdal, and Bredesen 1992;Hull 2002).…”

Section: Temperature ("Thermophoresis")mentioning

confidence: 99%

Dermal and Transdermal Drug Delivery Systems: Current and Future Prospects

et al. 2006

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Section: Temperature ("Thermophoresis")mentioning

confidence: 99%

Dermal and Transdermal Drug Delivery Systems: Current and Future Prospects

et al. 2006

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“…The enhancing effect of heat on transdermal and transvaginal absorption has been well documented (44)(45)(46)(47)(48)(49)(50)(51)(52), but its effect on the buccal mucosa has not been fully explored. Some investigators have shown an approximate doubling of transdermal flux with each 6-8°C increase in temperature from 10°C to 60°C (46,53).…”

Section: Introductionmentioning

confidence: 99%

“…Some investigators have shown an approximate doubling of transdermal flux with each 6-8°C increase in temperature from 10°C to 60°C (46,53). Another investigation studied the effect of increase in temperature on the permeability of selected B-agonist across primary hamster cheek pouch cultures (54).…”

Section: Introductionmentioning

confidence: 99%

Effect of Experimental Temperature on the Permeation of Model Diffusants Across Porcine Buccal Mucosa

Kulkarni

Ravichandran

et al. 2011

AAPS PharmSciTech

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Abstract. The influence of experimental temperature on the permeability of model diffusants across porcine buccal mucosa was investigated in vitro. The permeability increased significantly as the experimental temperature was increased in increments of approximately 7°C. It was observed that the apparent permeability and temperature were related by an exponential relationship that conformed to the Arrhenius equation. Diffusants with higher lipophilicities-buspirone and bupivacaine-had lower activation energies for diffusion when compared to hydrophilic diffusants-antipyrine and caffeine. The activation energy for diffusion of the model diffusants decreased linearly with increasing distribution coefficients across porcine buccal mucosa. The results suggested that the buccal mucosa acts as a stronger barrier to the diffusion of hydrophilic diffusants than the lipophilic ones. The log-linear relationship between permeability and temperature indicates that temperature should be carefully controlled in diffusion experiments. These results also point to the possibility of developing heat-generating buccal delivery devices, especially for hydrophobic diffusants.

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“…Previous in vitro studies (55,56) have demonstrated a 2-3 fold increase in flux for every 7-8˚C rise in skin surface temperature. The increased permeation following heat treatment has been attributed to an increase in drug diffusivity in the vehicle and an increase in drug diffusivity in the skin due to increased lipid fluidity (57). Vasodilation of the subcutaneous blood vessels as a homeostatic response to a rise in skin temperature also plays an important role in enhancing the transdermal delivery of topically applied compounds (58,59).…”

Section: Temperature ("Thermophoresis")mentioning

confidence: 99%