Effect of temperature on biochemical functions in the isolated perfused rat liver

“…Healing of the heated areas was seen. Hyperthermia of the whole liver caused some necrosis, more in that of the canine (Skibba and Condon, 1985) than the rat (Skibba and Collins, 1978;Miyazaki, 1983), with a 25% mortality in the former. Liver blood flow is reduced by hyperthermia as is that of innoculated liver tumours (Hugander et al, 1983) that undergo necrosis.…”

Section: )mentioning

confidence: 99%

Interstitial Laser Hyperthermia for the Treatment of Hepatic and Pancreatic Tumours

Steger

1991

Photochem & Photobiology

View full text Add to dashboard Cite

“…These include pH, nutrient levels and tbe bioehemical milieu (Field and Bleehen, 1979;Overgaard and Nielsen, 1980). This technique has recently been used to evaluate the biochemistry of the liver at high temperatures (Skibba and Collins, 1978;Boddie ct al., 1979;Bowers et ah, 1981).…”

Section: Introductionmentioning

confidence: 99%

Portal Vein Perfusion of the Isolated Rat Liver: Some Markers of Hyperthermic Liver Damage

Wynne

Mack

McRae

et al. 1984

Aust J Exp Biol Med

View full text Add to dashboard Cite

Summary.The cytoloxlc efTects of hyperthermia on tumours are readily measured. l';iramelers of injury to normal tissues are needed to evaluate therapeulic potential.Fifty-five isolated rat livers were perfused in vitro for 180 min in order to determine parameters of hyperthermic injury. During this period they were heated for I h at lemperaiures ranging from 37° to 45° and then assessed for evidence of hyperthermic injury.The most critical indicator of hyperthcrmic injury was sustained depression of bile production. Bile sccreiion decreased by 80% after heating at temperatures above 42°. A^partate amino transferase (AST) release increased significantly at temperatures of 42° and above.Potassium and variable amounts of glucose were released into the medium during heating, reflecting temporary changes in melabolism at high temperatures.

show abstract

Effect of temperature on biochemical functions in the isolated perfused rat liver

Cited by 32 publications

References 30 publications

An improved technique for isolated perfusion of rat livers and an evaluation of perfusates

An improved technique for isolated perfusion of rat livers and an evaluation of perfusates

Interstitial Laser Hyperthermia for the Treatment of Hepatic and Pancreatic Tumours

Portal Vein Perfusion of the Isolated Rat Liver: Some Markers of Hyperthermic Liver Damage

Contact Info

Product

Resources

About