Interstitial Laser Hyperthermia for the Treatment of Hepatic and Pancreatic Tumours

Steger, A. C.

doi:10.1111/j.1751-1097.1991.tb09898.x

Cited by 13 publications

(3 citation statements)

References 54 publications

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“…The simplest options are techniques for delivering heat using a probe that can be inserted directly into the pancreas under image guidance. Early studies used a laser fibre for doing this [4], as had been shown to be effective in other organs [5], but in recent years, radiofrequency ablation (RFA) has been the preferred option for interstitial thermal treatment of tumours in solid organs such as the liver and lungs, where it is now well established in routine use [6]. However, thermal ablation damages connective tissue like collagen, which reduces the mechanical integrity of hollow organs like the duodenum and bile duct, with the consequent risk of perforation if treatment extends to these organs.…”

Section: Focal Therapymentioning

confidence: 99%

Photodynamic therapy for cancer of the pancreas – The story so far

Bown

2016

Photonics &Amp; Lasers in Medicine

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Pancreatic cancer has long been a leading cause of cancer death. Few patients are suitable for surgery and for those who are not, the response to treatment is generally poor. No more than about 10% survive for more than a year. Recent research has focused on focal treatment for local disease control. This review covers the development of one of the most promising options, photodynamic therapy (PDT).This review covers pre-clinical and clinical studies. Laboratory work was designed to understand the effect of PDT on the normal pancreas and surrounding tissues and on transplanted cancers in the hamster pancreas to ensure safety prior to clinical application. Essentially all clinical studies have been undertaken in University College Hospital, London. Phase-I studies used the photosensitisers mTHPC and verteporfin in patients with localised but inoperable cancers.Laboratory results showed that normal pancreas, bile duct, liver, stomach and major blood vessels could tolerate PDT without any unacceptable effects on the structure and function of these organs. Necrosis that healed safely was documented in transplanted cancers. The clinical trials showed that focal necrosis could be produced in inoperable cancers with acceptable levels of complications, but considerable refinements of treatment delivery and monitoring are required before the technique will be ready for assessment in controlled clinical trials.PDT is showing promise for the minimally invasive treatment of localised pancreatic cancers, but it is still at an early stage of development. Much more work will be necessary to optimise techniques for applying PDT to these cancers and for combining it with other therapeutic options such as chemotherapy.

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Section: Focal Therapymentioning

confidence: 99%

Photodynamic therapy for cancer of the pancreas – The story so far

Bown

2016

Photonics &Amp; Lasers in Medicine

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“…Current clinical and laboratory research is focused upon using the 1064-nm laser wavelength to treat specific diseases such as benign prostatic hyperplasia 9 and cancer. [10][11][12][13] The optical properties of a phantom need not be identical to those of the tissue, but they may be related by having the same tissue diffusion coefficient, D (Dϭ a / eff 2 where eff 2 is the effective attenuation coefficient, and eff 2 ϭ 3 a ͓ a ϩ s (1 Ϫ g)͔). This allows the construction of phantoms that scatter and absorb light in the same manner as tissue, but over larger volumes.…”

Section: Introductionmentioning

confidence: 99%

Optical properties of scattering and absorbing materials used in the development of optical phantoms at 1064 nm

Royston

1996

J. Biomed. Opt.

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Optical phantoms have been developed to simulate the distribution of visible light in tissue. These phantoms can then be used to evaluate the performance of optical fiber delivery and/or radiometric detecting systems. This paper describes the development of an optical phantom for the neodymiun/yttrium-aluminum-garnet (Nd:YAG) laser wavelength of 1064 nm and the absorption coefficient, scattering coefficient, and anisotropy of the media used in its development.

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“…At temperatures of 60-300°C the tissue is coagulated, which can be observed macroscopically by blanching; at temperatures of 300 -1,OOO"C tissue ablation, vaporization, and carbonization occurs i p used, as its wavelength of 1,064 n m penetrates up to 8 mm into tissue [13,141. The light may be delivered noncontactly by aiming the laser beam on the tissue surface, or interstitially by implanting the light delivery fibers directly into the tissue [15][16][17][18]. Deep seated intrahepatic lesions may only be treated interstitially, whereas a n advantage of the noncontact technique could be a reduced chance of tumor spread owing to minimal tissue manipulation [19,201. In previous studies, we have investigated the noncontact technique in experimental liver metastases [21,22].…”

Section: Introductionmentioning

confidence: 99%

Water‐jet‐cooled Nd:YAG laser coagulation of experimental liver metastases: Correlation between ultrasonography and histology

et al. 1993

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To establish the value of ultrasonography in imaging laser coagulation of tumor and surrounding tissue, the relation between measurements on ultrasound and histology was determined in a rat tumor model. A piece of colon carcinoma CC531 was implanted in the liver of 21 Wag/Rij rats; 20 days later, tumors (mean diameter 5.3 mm) were treated with a water-jet-cooled Nd:YAG laser at 10 W and either 150 J, 300 J, 600 J, 1,200 J, 1,700 J, or 2,400 J. Ultrasonography was done just pre- and immediately post-laser treatment. The animals were sacrificed and livers removed for light microscopical evaluation. Depth and width of coagulation were measured directly on ultrasound, and on histological samples by computer-assisted image analysis. Laser treatment did not change the echogenic aspect of the tumor on ultrasound. However, liver damage appeared hypoechoic compared to normal liver. A significant correlation was found between the total size of the lesion on ultrasound and histology (P = 0.015, r = 0.57 for depth; P = 0.012, r = 0.58 for width), suggesting that laser induced tumor destruction may be derived from the amount of surrounding hepatic damage on ultrasound.

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Interstitial Laser Hyperthermia for the Treatment of Hepatic and Pancreatic Tumours

Cited by 13 publications

References 54 publications

Photodynamic therapy for cancer of the pancreas – The story so far

Photodynamic therapy for cancer of the pancreas – The story so far

Optical properties of scattering and absorbing materials used in the development of optical phantoms at 1064 nm

Water‐jet‐cooled Nd:YAG laser coagulation of experimental liver metastases: Correlation between ultrasonography and histology

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