Effect of taxifolin on cisplatin-associated oxidative optic nerve damage in rats

Ahiskali, Ibrahim; Okkay, Irmak Ferah; Mammadov, Renad; Okkay, Ufuk; Çimen, Ferda Keskin; Kurt, Nezahat; Süleyman, Halis

doi:10.1080/15569527.2020.1844726

Cited by 12 publications

(3 citation statements)

References 40 publications

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“…In a study by Zhao et al 33 taxifolin attenuated streptozocin-induced diabetes-related kidney damage in rats. In another study, it was stated that histopathological damage caused by oxidative stress and inflammation in rat optic nerve tissues with cisplatin was prevented by taxifolin 34 . These findings are consistent with both our biochemical results and the literature.…”

Section: Discussionmentioning

confidence: 99%

Effect of Taxifolin on Acrylamide-Related Oxidative Ovarian Damage, Infertility and Intrauterine Growth Retardation in Female Rats

Dinc¹,

Kiremitli²,

Kiremitli³

et al. 2023

International J. of Pharmacology

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Background and Objective: Acrylamide (AA) is a toxin that can cause reproductive organ toxicity and infertility through oxidative stress.This study aimed to investigate the effect of taxifolin, an antioxidant flavonoid, against acrylamide-induced infertility and intrauterine growth disorder in rats. Materials and Methods: Thirty-six rats were randomly divided into HG, ACR and TACR groups. The TACR group was given orally 50 mg kgG 1 of taxifolin. One hour later, 20 mg kgG 1 acrylamide was administered orally to the ACR and TACR groups. This procedure was repeated once a day for 30 days. Afterward, 6 rats in the groups were euthanized with 50 mg kgG 1 thiopental sodium. The removed ovaries were analyzed biochemically and histopathologically. Others were kept in the laboratory with male rats for 2 months for breeding. Rats that did not become pregnant and did not give birth during this period were considered infertile. Intrauterine growth retardation was assessed by the weight of the offspring. Results: Taxifolin decreased the levels of malondialdehyde (MDA), total oxidant system (TOS) and oxidative stress index (OSI) that increased with acrylamide in ovarian tissues while preventing the decrease in Total Glutathione (tGSH) and total antioxidant system (TAS) levels. In the histopathological examination, it was observed that the damage in the ACR group decreased with the application of taxifolin. In addition, it was determined that it significantly prevented infertility and the decrease the birth weight of the offspring. Conclusion: Taxifolin may be a potential therapeutic strategy to prevent acrylamide-induced ovarian damage, infertility and intrauterine growth retardation.

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Section: Discussionmentioning

confidence: 99%

Effect of Taxifolin on Acrylamide-Related Oxidative Ovarian Damage, Infertility and Intrauterine Growth Retardation in Female Rats

Dinc¹,

Kiremitli²,

Kiremitli³

et al. 2023

International J. of Pharmacology

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“…It has been documented that taxifolin protects liver tissue from oxidative damage by inhibiting the increase in MDA and TOS and decreasing the tGSH levels and TAS values due to pazopanib, an anticancer drug [13]. Another study reported that taxifolin protected optic nerve tissue against oxidative and inflammatory damage of the platinum-derived anticancer drug [34]. It has been argued that the protective effect of taxifolin is due to the inhibition of MDA, TNF-α, and IL-1β overproduction [35].…”

Section: Discussionmentioning

confidence: 99%

Effect of taxifolin on cyclophosphamide-induced oxidative and inflammatory bladder injury in rats

et al. 2022

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“…TAX [(2R, 3R) 3, 3ʹ, 4ʹ, 5, 7-pentahydroxy flavan-4-one], also known as dihydroquercetin, is a flavanol compound found in conifers such as Pinus Roxburghe and Siberian larch as well as in plant-based foods such as vegetables, fruits, wine, tea, and cocoa. Interestingly, numerous studies have shown that TAX has anti-inflammatory, antioxidant, antidiabetic, and hepatoprotective effects ( Sun et al, 2014 ; Cai et al, 2018 ; Lektemur Alpan et al, 2020 ; Ahiskali et al, 2021 ). TAX has been approved as a novel food ingredient by many countries including the US, United Kingdom, European Commission, and China ( Ding et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Polyvinylpyrrolidone-Modified Taxifolin Liposomes Promote Liver Repair by Modulating Autophagy to Inhibit Activation of the TLR4/NF-κB Signaling Pathway

Ding

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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Taxifolin (TAX) is a hepatoprotective flavanol compound, which is severely limited by poor solubility and low bioavailability. Liposomes (Lips) are used as well-recognized drug carrier systems that improve the water solubility and bioavailability of drugs, but are easily damaged by gastric juice after oral administration, resulting in the release of drugs in the gastric juice. Therefore, it is important to find materials that modify liposomes and avoid the destruction of the liposomal phospholipid bilayer structure by the gastrointestinal environment. Taxifolin liposomes (TAX-Lips) were modified by polyvinylpyrrolidone-k30 (PVP-TAX-Lips) and manufactured using a thin-film hydration technique. Particle size (109.27 ± 0.50 nm), zeta potential (−51.12 ± 3.79 mV), polydispersity coefficient (PDI) (0.189 ± 0.007), and EE (84.7 ± 0.2%) of PVP-TAX-Lips were studied. In addition, the results of in vitro release experiments indicated that the cumulative release rates of TAX-Lips and PVP-TAX-Lips were 89.73 ± 5.18% and 65.66 ± 4.86% in the simulated gastric fluid after 24 h, respectively, while the cumulative release rates were 68.20 ± 4.98% and 55.66 ± 3.92% in the simulated intestinal fluid after 24 h, respectively. Moreover, PVP-TAX-Lips were able to reverse lipopolysaccharide and D-galactosamine (LPS/D-GalN)-induced acute liver injury (ALI) by inducing autophagy to inhibit the expression levels of the TLR4/NF-κB signaling pathway and inflammatory factors, which suggested that PVP-TAX-Lips played an important role in the prevention of ALI and also provided a promising drug delivery system for the application of TAX.

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Effect of taxifolin on cisplatin-associated oxidative optic nerve damage in rats

Cited by 12 publications

References 40 publications

Effect of Taxifolin on Acrylamide-Related Oxidative Ovarian Damage, Infertility and Intrauterine Growth Retardation in Female Rats

Effect of Taxifolin on Acrylamide-Related Oxidative Ovarian Damage, Infertility and Intrauterine Growth Retardation in Female Rats

Effect of taxifolin on cyclophosphamide-induced oxidative and inflammatory bladder injury in rats

Polyvinylpyrrolidone-Modified Taxifolin Liposomes Promote Liver Repair by Modulating Autophagy to Inhibit Activation of the TLR4/NF-κB Signaling Pathway

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