Effect of Supersaturation on Crystal Size and Number of Crystals Produced in Antisolvent Crystallization.

Nitrendipine Nanocrystals: Its Preparation, Characterization, and In Vitro–In Vivo Evaluation

“…4, the particle size and the span values of the nanocrystals increased significantly when the concentration of nitrendipine in acetone reached 120 mg/ml. It has been reported that the induction period for nucleation tended to decrease with an increase in the concentration of solute (26). This caused the precipitation of nitrendipine from the system before it became uniform, and led to non-uniform crystallization, when the concentration of nitrendipine was too high.…”

Sonocrystallisation of sodium chloride particles for inhalation

“…Previous studies on antisolvent NaCl crystallisation found this precipitation method to provide a limited application because it produced NaCl particles not in the respiratory range and/or particle shapes inappropriate for aerosol delivery (Zijlema et al, 1999;Doki et al, 2002;Kaneko et al, 2002;Purssell et al, 2004;Toth et al, 2005). Because of these limitations, an alternative production process will be necessary.…”

Computational fluid dynamics modeling of mixing effects for crystallization in coaxial nozzles

“…The latter two correlations are expected due to Eqs. (24) and (25). All these variables reach their maxima on the nozzle axis (center), and slightly downstream of the mixing junction.…”

“…Various experimental studies of antisolvent crystallization in an agitated semibatch vessel indicate that the crystal size distribution (CSD) depends strongly on operating conditions such as agitation rate, mode of addition (direct or reverse), addition rate, solvent composition, and size of the crystallizer [3,[19][20][21][22][23][24][25][26][27][28][29][30][31]. The polymorphic or pseudopolymorphic form can also depend on the operating conditions [32][33][34][35][36][37].…”