Sonocrystallisation of sodium chloride particles for inhalation

Abbas, Ali; Srour, M.H.; Tang, Patricia A.; Chiou, Herbert; Chan, Hak‐Kim; Romagnoli, José A.

doi:10.1016/j.ces.2007.01.052

Cited by 60 publications

(43 citation statements)

References 40 publications

(41 reference statements)

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“…An insignificant effect of the ultrasonic power between 10 W and 25 W was observed on the final PSD during a batch crystallization of a commercial drug substance [46]. In contrast, several other papers in the literature claim smaller particle sizes upon higher power levels [22,[47][48][49]. However, these articles applied ultrasound for a long time during the whole crystallization process.…”

Section: Influence Of the Power Levelmentioning

confidence: 70%

Ultrasound Assisted Particle Size Control by Continuous Seed Generation and Batch Growth

et al. 2017

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Controlling particle size is essential for crystal quality in the chemical and pharmaceutical industry. Several articles illustrate the potential of ultrasound to tune this particle size during the crystallization process. This paper investigates how ultrasound can control the particle size distribution (PSD) of acetaminophen crystals by continuous seed generation in a tubular crystallizer followed by batch growth. It is demonstrated that the supersaturation ratio at which ultrasound starts seed generation has a substantial effect on the final PSD while the applied power is insignificant in the studied conditions. The higher the supersaturation ratio, the smaller the final crystals become up to a supersaturation ratio of 1.56. Furthermore, it was shown that ultrasound can also impact the final PSD when applied during the growth phase. Frequencies of 850 kHz or below reduce the final particle size; the lower the applied frequency, the smaller the crystals become. In conclusion, one could state that ultrasound is able to control the particle size during seed generation and subsequent growth until the final particle size.

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Section: Influence Of the Power Levelmentioning

confidence: 70%

Ultrasound Assisted Particle Size Control by Continuous Seed Generation and Batch Growth

et al. 2017

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“…This leads to the release of large localized amounts of energy that subsequently go through a phase of extremely fast temperature reduction ultimately resulting in the generation of a significant number of nuclei. Consequently, supersaturation and hence crystal growth is distributed to the many forming nuclei leading to large numbers of smaller particles [Abbas, 2007]. Untreated FBP showed a higher elongation ratio that was slightly more elongated than the treated FBP (Table 1).…”

Section: Particle Size and Morphologymentioning

confidence: 97%

“…Apart from constituting a rapid application, melt sonocrystallization also offers further advantages, including smaller crystal size compared with conventional crystallization and cost-effectiveness of apparatus. The process can be run under ambient conditions and the reaction vessel involved is of simple geometry, making the cleaning process simpler for pharmaceutical requirements [Abbas et al, 2007].…”

Section: Introductionmentioning

confidence: 99%

Improvement of physicochemical and biopharmaceutical properties of flurbiprofen using melt sonocrystallization technique

El-Kamel

2008

Drug Development Research

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The aim of the present study was to investigate the suitability of the melt sonocrystallization technique to modify the undesirable properties of the nonsteroidal anti-inflammatory drug (NSAID), flurbiprofen (FBP), e.g., poor flowability, solubility, and dissolution rate and, consequently, poor bioavailability. FBP melt was poured in deionized water at 251C and sonicated for 4 min at an amplitude of 60% and cycle of 40 s on and 10 s off. The product obtained was evaluated using scanning electron microscopy (SEM), image analysis, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), and X-ray powder diffraction (XRPD). Flow properties, intrinsic dissolution rate, solubility, and bioavailability were also evaluated. The particle size of the treated FBP was significantly reduced. Thermal behavior and FT-IR spectra of untreated and treated FBP have shown no significant difference. Low-intensity peaks in the X-ray diffraction of treated FBP were noticed. In addition there was significant enhancement in the flow properties of treated FBP, as indicated by the value of angle of repose and the flow constants calculated from the Kawakita equation. The increased solubility of treated FBP was about 35%. The intrinsic dissolution rate of treated FBP increased by 2-fold. The dissolution rate studies revealed that 90% of the drug was released within 20 min for treated FBP compared with 60% released for the untreated drug. The relative bioavailability of treated FBP was increased by 2-fold compared with untreated drug.The use of melt sonocrystallization technique is a promising technique that may afford powder with improved flow and tablet functionality as well as improved dissolution and bioavailability. Drug Dev Res 69: [34][35][36][37][38][39][40][41] 2008 r2008 Wiley-Liss, Inc.

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“…One common type of batch-crystallisation operation that is widely utilised in the pharmaceutical, food, and chemical industries is antisolvent crystallisation. In this technique, a solute is crystallised from solution by the addition of an antisolvent that effectively reduces the original solubility of the solute and thus increases the supersaturation in the bulk solution [9][10][11]. However, a considerable amount of antisolvent is necessary for the selective crystallisation of polymorphs with lower stability because the generated polymorph changes in order of the stable form, metastable form, and unstable form with an increase in supersaturation of the bulk solution [12].…”

Section: Introductionmentioning

confidence: 99%

Change in glycine polymorphs induced by minute-bubble injection during antisolvent crystallisation

Matsumoto

Wada

Onoe

2015

Advanced Powder Technology

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Sonocrystallisation of sodium chloride particles for inhalation

Cited by 60 publications

References 40 publications

Ultrasound Assisted Particle Size Control by Continuous Seed Generation and Batch Growth

Ultrasound Assisted Particle Size Control by Continuous Seed Generation and Batch Growth

Improvement of physicochemical and biopharmaceutical properties of flurbiprofen using melt sonocrystallization technique

Change in glycine polymorphs induced by minute-bubble injection during antisolvent crystallisation

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