Effect of sparteine on status epilepticus induced in rats by pentylenetetrazole, pilocarpine and kainic acid

Villalpando-Vargas, Fridha Viridiana; Medina‐Ceja, Laura

doi:10.1016/j.brainres.2015.07.017

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…exhibited a delay in the onset of first seizure and prolonged survival time [43]. Most recently, a study of Wistar rats provided support for the anticonvulsant effect of sparteine [57]. In this work, sparteine (13 mg/kg, i.p.)…”

Section: Experimental Evidence Regarding the Anticonvulsant Action Ofmentioning

confidence: 58%

“…In the pilocarpine model, sparteine blocked the epileptiform activity in 16% of the animals throughout the entire experiment. Additionally, sparteine prevented the establishment of SE in some animals in each of the three models, which also demonstrated its anticonvulsant effect [57].…”

Section: Experimental Evidence Regarding the Anticonvulsant Action Ofmentioning

confidence: 68%

“…Additionally, sparteine (13 mg/kg, i.p.) does not induce behavioral changes, and the electroencephalographic (EEG) activities of animals treated with this concentration of sparteine are characterized by slow, low-amplitude and -frequency activity compared with control animals treated with saline solution [57].…”

Section: Effects Of Sparteine In the Central Nervous Systemmentioning

confidence: 98%

“…It is possible that sparteine exerts its anticonvulsive effects in the CNSs of SE rats not only through the mechanism of action proposed in the present review but also due to its systemic effects following intraperitoneal or oral administration [9,43,57]. The early systemic complications after SE are well known to be related to the metabolic demands of the brain that produce increased cerebral blood flow, cardiovascular changes and catecholamine release effects, such as tachycardia, hypertension, hyperpyrexia, hyperglycemia, brain inflammation and blood-brain barrier disruption [75,76].…”

Section: Mechanism Of Action Of Sparteinementioning

confidence: 99%

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Sparteine as an anticonvulsant drug: Evidence and possible mechanism of action

Villalpando-Vargas

Medina‐Ceja

2016

Seizure

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Sparteine is a quinolizidine alkaloid extracted from Lupinus that has numerous pharmacological properties both in humans and animal models. In the central nervous system, sparteine reduces locomotor activity, has light analgesic effects, also has no effects on short-term memory or spatial learning and does not induce changes in behavior or electroencephalographic (EEG) activity. However, the anticonvulsant profile of sparteine is not fully characterized in experimental animals and there are no data in humans. Therefore, the present review focuses on the experimental evidence supporting the anticonvulsant action of sparteine in models of acute seizures and status epilepticus (SE), as well as its possible mechanisms of action. The evidence that supports the anticonvulsant effect of (-)-Sparteine sulfate includes the inhibition of seizures induced by maximal electro-stimulation, a delay in the onset of convulsive behavior and the prolongation of survival time in mice treated with pentylenetetrazole (PTZ). Additionally, sparteine delays the onset of convulsive behavior and decreases the severity and mortality of rats treated with PTZ and pilocarpine. Sparteine decreases amplitude and frequency or blocks the epileptiform activity induced by PTZ, pilocarpine and kainic acid. Sparteine may decrease hyperexcitability through the activation of the M2 and M4 subtypes of mAChRs, which is a probable mechanism of action that together with its systemic effects may favor its anticonvulsant effects against seizures and SE.

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Section: Experimental Evidence Regarding the Anticonvulsant Action Ofmentioning

confidence: 58%

Section: Experimental Evidence Regarding the Anticonvulsant Action Ofmentioning

confidence: 68%

Section: Effects Of Sparteine In the Central Nervous Systemmentioning

confidence: 98%

Section: Mechanism Of Action Of Sparteinementioning

confidence: 99%

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Sparteine as an anticonvulsant drug: Evidence and possible mechanism of action

Villalpando-Vargas

Medina‐Ceja

2016

Seizure

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“…It was also found that lupanine potentiates the release of insulin by glucose, becoming a tool in the treatment of type II diabetes [ 58 ], and that sparteine (alkaloid present in small amounts in lupine, which can be easily obtained from lupanine) has the ability to be anticonvulsant [ 59 ].…”

Section: Antinutritive Factorsmentioning

confidence: 99%

Lupin (Lupinus albus L.) Seeds: Balancing the Good and the Bad and Addressing Future Challenges

2022

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Lupinus albus L. (lupine) is a legume whose grain/seed has gained increasing interest. Its recognized nutritional properties, namely a high content of protein, dietary fiber and its low fat content, make lupine a suitable alternative not only for animal protein, but also as a substitute for more processed and less balanced flours from a nutritional point of view, used in the preparation of bread, cakes and cookies, among others. In addition, its nutritional and bioactive compounds have potential benefits for human health in the prevention and treatment of some diseases. However, the existence of some anti-nutritional compounds and contaminants reveal some concern, requiring effective methods for their detection and eventual removal. This review intends to address the potential of lupine (L. albus) in food and human health and to balance the pros and cons. Nutritional and anti-nutritional components of L. albus seeds and possible contaminants of lupine seeds are examined. The potential health benefits of lupine (seeds), including energy metabolism, cardiovascular diseases, hypertension, glucose and insulin metabolism, bower function and anticonvulsant action, are discussed based on scientific evidence (both clinical trials and studies performed with animal models).

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Behavioral and genotoxic evaluation of rosmarinic and caffeic acid in acute seizure models induced by pentylenetetrazole and pilocarpine in mice

Coelho

Vieira

Souza

et al. 2016

Naunyn-Schmiedeberg's Arch Pharmacol

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The goal of this study was to investigate the effects of rosmarinic acid (RA) and caffeic acid (CA) in the acute pentylenetetrazole (PTZ) and pilocarpine (PIL) seizure models. We also evaluated the effect of RA and CA on the diazepam (DZP)-induced sleeping time test and its possible neuroprotective effect against the genotoxic damage induced by PTZ and PIL. Mice were treated intraperitoneally (i.p.) with saline, RA (2 or 4 mg/kg), or CA (4 or 8 mg/kg) alone or associated to low-dose DZP. After, mice received a single dose of PTZ (88 mg/kg) or PIL (250 mg/kg) and were monitored for the percentage of seizures and the latency to first seizure (LFS) >3 s. Vigabatrin and DZP were used as positive controls. In the DZP-induced sleeping time test, mice were treated with RA and CA and 30 min after receiving DZP (25 mg/kg, i.p.). The alkaline comet assay was performed after acute seizure tests to evaluate the antigenotoxic profiles of RA and CA. The doses of RA and CA tested alone did not reduce the occurrence of seizures induced by PTZ or PIL. The association of 4 mg/kg RA + low-dose DZP was shown to increase LFS in the PTZ model, compared to the group that received only the DZP. In the DZP-induced sleeping time test, the latency to sleep was reduced by 4 mg/kg RA and 8 mg/kg CA. The PTZ-induced genotoxic damage was not prevented by RA or CA, but the PIL-induced genotoxic damage was decreased by pretreatment with 4 mg/kg RA (in cortex) and 4 mg/kg CA (in hippocampus). In conclusion, RA and CA presented neuroprotective effect against PIL-induced genotoxic damage and reduced the latency to DZP-induced sleep. Of the rosmarinic acid, 4 mg/kg enhanced the DZP effect in the increase of latency to clonic PTZ-induced seizures.

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Effect of sparteine on status epilepticus induced in rats by pentylenetetrazole, pilocarpine and kainic acid

Cited by 9 publications

References 36 publications

Sparteine as an anticonvulsant drug: Evidence and possible mechanism of action

Sparteine as an anticonvulsant drug: Evidence and possible mechanism of action

Lupin (Lupinus albus L.) Seeds: Balancing the Good and the Bad and Addressing Future Challenges

Behavioral and genotoxic evaluation of rosmarinic and caffeic acid in acute seizure models induced by pentylenetetrazole and pilocarpine in mice

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