Sparteine as an anticonvulsant drug: Evidence and possible mechanism of action

Villalpando-Vargas, Fridha Viridiana; Medina‐Ceja, Laura

doi:10.1016/j.seizure.2016.05.010

Cited by 29 publications

(22 citation statements)

References 52 publications

(69 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Each lupin species produces a characteristic pattern of QAs with few major compounds and several others as traces [2][3][4]. The chemical properties and insecticidal, antimicrobial, and medicinal activities of QAs are of interest in the chemical, biotechnological, and pharmaceutical industries [5][6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Unraveling the Biosynthesis of Quinolizidine Alkaloids Using the Genetic and Chemical Diversity of Mexican Lupins

et al. 2021

View full text Add to dashboard Cite

Quinolizidine alkaloids (QAs) are synthesized by the genus Lupinus as a defense against herbivores. Synthesis of QAs in lupins is species- and organ-specific. Knowledge about their biosynthesis and their corresponding pathways are still fragmentary, in part because lupins of commercial importance were mainly investigated, representing a small sample of the chemodiversity of the genus. Here, we explore the use of three Mexican lupins: Lupinus aschenbornii, Lupinus montanus, and Lupinus bilineatus as a model to study the physiology of QA biosynthesis. The corresponding QA patterns cover widely and narrowly distributed tetracyclic QAs. Quinolizidine alkaloid patterns of seeds and plantlets at different developmental stages were determined by GLC–MS and compared to identify the onset of de novo QA synthesis and to gain insight into specific and common biosynthesis trends. Onset of de novo QA biosynthesis occurred after the metabolization of seed QA during germination and was species-specific, as expected. A common QA pattern, from which the diversity of QA observed in these species is generated, was not found; however, lupanine and 3β-lupanine were found in the three specieswhile sparteine was not found in Lupinus bilineatus, suggesting that this simplest tetracyclic QA is not the precursor of more complex QAs. Similar patterns of metabolization and biosynthesis of structurally related QAs were observed, suggesting a common regulation.

show abstract

Section: Introductionmentioning

confidence: 99%

Unraveling the Biosynthesis of Quinolizidine Alkaloids Using the Genetic and Chemical Diversity of Mexican Lupins

et al. 2021

View full text Add to dashboard Cite

show abstract

“…When eight crops were discussed in the context of their eligibility as major sources of plant protein for Western Europe, considering their agronomic advantages, prospects for quick improvement, yield and quality of protein, technological aspects, functional and nutritional properties, lupine and pea were recognized as preferential over potato, triticale, alfalfa, etc. (Linnemann, Dijkstra, 2002;Dijkstra et al, 2003).…”

Section: Narrow-leaved Lupine As Human Foodmentioning

confidence: 99%

Alkaloids of narrow-leaved lupine as a factor determining alternative ways of the crop’s utilization and breeding

et al. 2020

View full text Add to dashboard Cite

Narrow-leaved lupine (Lupinus angustifolius L.), a valuable leguminous crop adapted to a wide range of climatic conditions, has a very short history of domestication. For many centuries it was used mainly as a green manure, since the success and prospects of the multi-purpose use of the species depend on its breeding improvement, in particular, on a particular concentration of alkaloids in seeds and green mass. The first varieties of scientific breeding were created only in the 1930s after the appearance of low-alkaloid mutants. Despite wide prospects for use in various areas of the national economy, unstable productivity and susceptibility to diseases hinder the production of this crop. Obviously, breeders deal only with a small part of the gene pool of the species and limited genetic resources, using mainly low-alkaloid (sweet) genotypes to create new varieties. The genetic potential of the species can be used more efficiently. At the same time, it is rational to create highly alkaloid (bitter) varieties for green manure, while food and feed varieties should not lose their adaptive potential, in particular, resistance to pathogens, due to the elimination of alkaloids. In this regard, it seems to be a productive idea to create ‘bitter/sweet’ varieties combining a high content of alkaloids in the vegetative organs and low in seeds, which can be achieved by regulating the synthesis/transport of alkaloids in the plant. The paper discusses the current state of use of the species as a green manure, fodder, food plant. Information is given on the quantity and qualitative composition of narrow-leaved lupine alkaloids, their applied value, in particular, fungicidal, antibacterial, insecticidal, the use of lupine alkaloids as active principles of drugs. Along with promising breeding considerations, the possibility of using technologies for processing raw high-alkaloid materials with the accompanying extraction of valuable ingredients for pharmaceuticals is discussed. Information is briefly presented about the genomic resources of the species and the prospects for their use in marker-assistant selection and genome editing.

show abstract

“…The potential anticonvulsant impact of sparteine might be interceded through the restraint of acetylcholine discharge and the consequent arrival of GABA in the mind because of the actuation of the M2 and M4 subtypes of mAChRs. These impacts joined with the foundational impacts of diminishing pulse and pulse notwithstanding the calming and hypoglycemic properties of sparteine, recommend that sparteine guarantees to be a vital anticonvulsant [103]. Cytisine, a nicotinic acetylcholine receptor halfway agonist (like varenicline) found in certain plants, is a minimal effort, viable smoking end drug [104].…”

Section: Pyrrole: Stachydrinementioning

confidence: 99%

Chemistry of Secondary Metabolites

Mohiuddin¹

2019

ACT

View full text Add to dashboard Cite

Medicinal plants, are known to deliver a wide scope of Plant Secondary Metabolites (PSMs) connected as bug sprays, medications, colors and poisons in farming, prescription, industry and biofighting in addition to bio-fear mongering, separately. Be that as it may, creation of PSMs is for the most part in little amounts, so we have to discover novel approaches to increment both amount and nature of them. Luckily, biotechnology proposes a few choices through which secondary metabolism in plants can be built in imaginative approaches to: 1) over-produce the valuable metabolites, 2) down-produce the poisonous metabolites, 3) produce the new metabolites. Secondary metabolites are extensively characterized as natural products integrated by a life form that is not basic to help development and life. The plant kingdom fabricates more than 200,000 unmistakable chemical compounds, a large portion of which emerge from particular metabolism. While these compounds assume critical jobs in interspecies challenge and safeguard, many plant natural products have been abused for use as prescriptions, scents, flavors, supplements, repellants, and colorants. In spite of this immense chemical decent variety, numerous secondary metabolites are available at low focuses in plant a, taking out yield based assembling as methods for achieving these imperative products. The basic and stereo chemical unpredictability of particular metabolites frustrates most endeavors to get to these compounds utilizing chemical blend. Albeit local plants can be built in amass target pathway metabolites. This Update gives a concise outline of designing plant secondary metabolism in microbial frameworks. We quickly diagram biosynthetic pathways intervening arrangement of the real classes of natural products with an accentuation on high-esteem terpenoids, alkaloids, phenylpropanoids, and polyketides. We additionally feature basic topics, techniques, and provoke hidden endeavors to reproduce and build these pathways in microbial hosts. We center mostly around again biosynthetic methodologies in which plant specific metabolites are combined straightforwardly from sugar feed stocks instead of enhanced forerunners or intermediates.

show abstract

Sparteine as an anticonvulsant drug: Evidence and possible mechanism of action

Cited by 29 publications

References 52 publications

Unraveling the Biosynthesis of Quinolizidine Alkaloids Using the Genetic and Chemical Diversity of Mexican Lupins

Unraveling the Biosynthesis of Quinolizidine Alkaloids Using the Genetic and Chemical Diversity of Mexican Lupins

Alkaloids of narrow-leaved lupine as a factor determining alternative ways of the crop’s utilization and breeding

Chemistry of Secondary Metabolites

Contact Info

Product

Resources

About