Effect of Sorbed Water on Disintegrant Performance of Four Brands of Polacrilin Potassium NF

Abstract

Abstract. Polacrilin Potassium NF is a commonly used weak cation exchange resin disintegrant in pharmaceutical tablets. The objective of this research was to evaluate the effects of sorbed moisture on physical characteristics and disintegrant performance of four brands of Polacrilin Potassium NF. The disintegrants were stored in five different relative humidity chambers and their dynamic vapor adsorption-desorption analysis, effect of moisture on their compressibility, compactability, particle size, morphology, water uptake rate, and disintegration ability were studied. Moisture seemed to plasticize the disintegrants, reducing their yield pressures. However, certain optimum amount of moisture was found to be useful in increasing the compactablity of the tablets containing disintegrants. The tablets, however, lost their tensile strengths beyond this optimum moisture content. Moisture caused two brands of the disintegrants to swell; however, two other brands aggregated upon exposure to moisture. Swelling without aggregation increased the water uptake, and in turn the disintegrant performance. However, aggregation probably reduced the porosities of the disintegrants, reducing their water uptake rate and disintegrant performance. Different brands of Polacrilin Potassium NF differed in the abilities to withstand the effects of moisture on their functionality. Effect of moisture on disintegrant performance of Polacrilin Potassium NF needs to be considered before its use in tablets made by wet granulation.

Evaluation of some anionic exchange resins as potential tablet disintegrants

“…These mechanisms also accounted for the disintegrating property of polacrilin potassium, a cationic exchange resin practically usable as a disintegrant [5]. The longer disintegration time obtained from Dowex1®x4 and x8, respectively, were in agreement with the lower ability for hydration and swelling of the resins.…”

“…To this regard, a new group of disintegrants, referred to as "superdisintegrants", has been developed. Several materials proven to be superdisintegrants are sodium starch glycolate (modified starch), croscarmellose sodium (crosslinked cellulose), crospovidone (crosslinked polyvinylpyrrolidone) and polacrilin potassium (cationic exchange resin) [3][4][5][6].…”

“…The ionizable groups make the resin capable of hydration and swelling in an aqueous fluid [7]. Therefore, ion exchange resins have been exploited as effective disintegrants in tablet formulation [5,6], in addition to other diverse applications [8,9]. Nonetheless, this disintegrant application has been limited to only a cationic exchange resin derived from crosslinked methacrylic acid and divinylbenzene copolymer in a potassium salt form, i.e.…”

“…Nonetheless, this disintegrant application has been limited to only a cationic exchange resin derived from crosslinked methacrylic acid and divinylbenzene copolymer in a potassium salt form, i.e. polacrilin potassium (Amberlite IRP88®, Indion 294® and Tulsion 339®) [5]. Therefore, the goal of this work was to expand such interesting applications to anionic exchange resins, which, to the best of our knowledge, has never been reported.…”

Formulation and characterization of fast dissolving tablets using salvia hispanica (chia seed) mucilage as superdisintegrant

“…5 Diverse factors influencing the disintegration process of the tablet include the particle size, moisture content, compression force, type and properties of the disintegrant, tablet hardness, nature of the drug, compatibility with other ingredients and the process of addition as well as mixing. 6,7 The crucial mechanisms involved in the tablet disintegration process include swelling, deformation, wicking, enzymatic reactions and repulsions between the particles. 8 Different categories of superdisintegrants include natural (like Gums and mucilage) and synthetic superdisintegrants (croscarmellose sodium, crospovidone, carmellose, sodium starch glycollate etc.).…”