Applications of Polymers as Pharmaceutical Excipients in Solid Oral Dosage Forms

Debotton, Nir; Dahan, Arik

doi:10.1002/med.21403

Cited by 100 publications

(43 citation statements)

References 143 publications

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“…An excipient is a pharmacologically inert substance or non‐active ingredient that is added to a formulation to stabilize the active substance or enhance the function of the dosage form (Debotton and Dahan, ). Most excipients are not absorbed from the gut lumen.…”

Section: The Effects Of Drug Therapy On the Gut Microbiomementioning

confidence: 99%

Drug–gut microbiota interactions: implications for neuropharmacology

Walsh

Griffin

Clarke

et al. 2018

British J Pharmacology

103

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The fate and activity of drugs are frequently dictated not only by the host per se but also by the microorganisms present in the gastrointestinal tract. The gut microbiome is known to, both directly and indirectly, affect drug metabolism. More evidence now hints at the effects that drugs can have on the function and composition of the gut microbiome. Both microbiota-mediated alterations in drug metabolism and drug-mediated alterations in the gut microbiome can have beneficial or detrimental effects on the host. Greater insights into the mechanisms driving these reciprocal drug-gut microbiota interactions are needed to guide the development of microbiome-targeted dietary or pharmacological interventions, which may have the potential to enhance drug efficacy or reduce drug side effects. In this review, we explore the relationship between drugs and the gut microbiome, with a specific focus on potential mechanisms underpinning the drug-mediated alterations on the gut microbiome and the potential implications for psychoactive drugs. LINKED ARTICLES: This article is part of a themed section on When Pharmacology Meets the Microbiome: New Targets for Therapeutics? To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.24/issuetoc.

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Section: The Effects Of Drug Therapy On the Gut Microbiomementioning

confidence: 99%

Drug–gut microbiota interactions: implications for neuropharmacology

Walsh

Griffin

Clarke

et al. 2018

British J Pharmacology

103

View full text Add to dashboard Cite

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“…Для получения таблеток с пролонгированным высвобождением можно применять полимеры этой линейки со средними или низкими значениями вязкости Methocel®K4M, Methocel® K100 LV, Methocel® Premium, Methocel® Premium CR, Methocel Premium DC2 и т. д. [16,17].…”

Section: современные гидрофильные полимеры для лекарственных форм с пunclassified

“…Скорость и интенсивность высвобождения АФИ из таблеток на основе инертных матриц можно контролировать типом и количеством порообразующих веществ, но также и типом самого полимера [16].…”

Section: нерастворимые в воде полимеры для создания инертных матричныunclassified

Modern polymers in prolonged release tablet technology

et al. 2020

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Currently, the delivery systems of second and third generation are of particular interest among pharmaceutical forms. Second generation pharmaceutical forms include systems with prolonged release of the active substance, third generation pharmaceutical forms include systems with controlled release. A slow continuous release of a medicinal substance may be achieved by using special excipients or by using special technologies. For the production of tablets with prolonged release, the most common are special excipients, namely, polymers and their compositions. The use of polymers as carriers of pharmaceutical substances used to program the kinetic frequency and location of the release is known since the middle of XX century [9]. To date, significant progress has been made in the use of polymers to prolong the release: the influence and interaction of polymers and drugs have been studied, the mechanisms of drug release have been studied, ways of programming release kinetics using various properties of polymers, etc. In the article the modern state in the field of technology of tablets with prolonged release is considered. Advantages of prolonged release, mathematical models for description of drug forms with prolonged release are described. Technologies of tablets with prolonged release, types of delivery systems and mechanisms of release of an active pharmaceutical ingredient are considered. The article presents modern polymers that are used in the technology of tablets with prolonged release. The classification of polymers in relation to water and to physiological liquids is presented.

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“…As previously indicated, tablets contain a determined amount of drug substance that is designed to provide a desired therapeutic efficacy. Also included in tablet formulations are inert excipients, which are bulking agents, fillers disintegrants or other specialized and non-conventional excipients [85]. In general, tablets dissolve in the stomach and absorb in the lower GI track.…”

Section: Tablet Splitting: Current Practicementioning

confidence: 99%

Tablet Scoring: Current Practice, Fundamentals, and Knowledge Gaps

Jacques

Alexandridis

2019

Applied Sciences

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Oral solid dosage formulations and/or tablets have remained the preferred route of administration by both patients and health care practitioners. Oral tablets are easy to administer, they are non-invasive and cause less risk adversity. Because of the lack of commercially available tablet dose options, tablets are being split or partitioned by users. Tablet scoring refers to the breakage of a tablet to attain a desired efficacy dose and is an emerging concept in the pharmaceutical industry. The primary reason for the tablet scoring practice is to adjust the dose: dose tapering or dose titrating. Other reasons for tablet partitioning are to facilitate dose administration, particularly among the pediatric and the geriatric patient population, and to mitigating the high cost of prescription drugs. The scope of this review is to: (1) evaluate the advantages and inconveniences associated with tablet scoring/portioning, and (2) identify factors in the formulation and the manufacturing of tablets that influence tablet splitting. Whereas tablet partitioning has been a common practice, there is a lack of understanding regarding the fundamentals underpinning the performance of tablets with respect to splitting. Several factors can influence tablet partitioning: tablet size, shape, and thickness. A requirement has recently been set by the European Pharmacopoeia and the U.S. Food and Drug Administration for the uniformity of mass of subdivided tablets. For breaking ease, an in-vivo reference test and a routinely applicable in-vitro test need to be established.

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Applications of Polymers as Pharmaceutical Excipients in Solid Oral Dosage Forms

Cited by 100 publications

References 143 publications

Drug–gut microbiota interactions: implications for neuropharmacology

Drug–gut microbiota interactions: implications for neuropharmacology

Modern polymers in prolonged release tablet technology

Tablet Scoring: Current Practice, Fundamentals, and Knowledge Gaps

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