Effect of Somatotropin on Changes in Milk Production and Composition During Coliform Mastitis in Periparturient Cows

Messom, G Vandeputte-Van; Burvenich, Christian

doi:10.3168/jds.s0022-0302(93)77715-2

Cited by 16 publications

(17 citation statements)

References 22 publications

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“…Indeed, it has been observed that the clinical condition of severe cases only starts to deteriorate after one or two days postinfection, which is much later that the onset of clinical mastitis [98]. This idea is in agreement with the concept that severity of coliform mastitis can be estimated on basis of the milk loss in the uninfected quarters, 48 hours after infection [59,93,125,244,245].…”

Section: Circulating Leukocytessupporting

confidence: 64%

“…The sporadic detection of limited LPS amounts in plasma contrasts with the massive LPS amounts that are released in the mammary gland during E. coli mastitis [246]. In the LPS model, the inflammatory reaction is induced by "bolus injection"; in the E. coli infection model, LPS is released during several hours [64,93,97,124,161,167,210,244,245]. Most LPS mastitis models described in literature are performed after peak lactation.…”

Section: Endotoxin As Systemic Mediatormentioning

confidence: 99%

“…E. coli with large numbers of bacteria in the udder cistern can occur. This is especially related with the period of parturition and early lactation [26,41,59,79,93,97,125,126,145,167,210,241,244,245] and this explosive growth of I.M. E. coli is less apparent during established lactation [16,97,98,102,195,210].…”

Section: Local Disease Parametersmentioning

confidence: 99%

“…[244]). Nowadays we know that several host determinants influence the sensitivity for coliform mastitis, i.e.…”

Section: Is Severity Predictable?mentioning

confidence: 99%

“…The above mentioned findings inspired investigators to evaluate the potential protective effects of recombinant bovine somatotropin (rbST) during coliform mastitis, because during this disease the neutrophil plays a pivotal role in its outcome [244]. In a first study, 19 cows, classified as moderate or severe responders (based on the respiratory burst activity of blood neutrophils before challenge), were treated with rbST or vehicle, 48 h after I.M.…”

Section: Effect Of Rbst On Milk Loss During Mastitismentioning

confidence: 99%

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Severity of E. coli mastitis is mainly determined by cow factors

et al. 2003

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-Intramammary infections of dairy cows with Gram-positive bacteria such as Staphylococcus aureus (major cause of mastitis) have received a lot of attention because of their major economic impact on the dairy farm through production losses induced by an increase in somatic cell count. Management strategies, including greater awareness for efficient milking and hygienic measures, have limited the spread of Gram-positive bacteria and resulted in a significant decrease of proportion of S. aureus isolates and subclinical mastitis worldwide. Other organisms such as coliform subspecies and Streptococcus uberis, both environmental bacteria that cause clinical mastitis, have received less attention. Escherichia coli causes inflammation of the mammary gland in dairy cows around parturition and during early lactation with striking local and sometimes severe systemic clinical symptoms. This disease affects many high producing cows in dairy herds and may cause several cases of death per year in the most severe cases. It is well known that bacterial, cow and environmental factors are interdependent and influence mastitis susceptibility. Many studies, executed during the last decade, indicate that the severity of E. coli mastitis is mainly determined by cow factors rather than by E. coli pathogenicity. During E. coli mastitis, the host defense status is a cardinal factor determining the outcome of the disease. Today, we know that the neutrophil is a key factor in the cows' defense against intramammary infection with E. coli. Effective elimination of the pathogen by neutrophils is important for the resolution of infection and the outcome of E. coli mastitis. This review is a compilation of some major findings over the last 15 years concerning mainly host factors that modulate and influence neutrophil function and the mammary inflammatory reaction. The individual chapters address: virulence factors of E. coli strains, how neutrophils kill E. coli, connection between endotoxins, tumor necrosis factor-a and nitric oxide, severity classification of E. coli mastitis, lifespan of neutrophils, host factors that influence severity, tissue damage and production loss.

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Section: Circulating Leukocytessupporting

confidence: 64%

Section: Endotoxin As Systemic Mediatormentioning

confidence: 99%

Section: Local Disease Parametersmentioning

confidence: 99%

“…[244]). Nowadays we know that several host determinants influence the sensitivity for coliform mastitis, i.e.…”

Section: Is Severity Predictable?mentioning

confidence: 99%

Section: Effect Of Rbst On Milk Loss During Mastitismentioning

confidence: 99%

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Severity of E. coli mastitis is mainly determined by cow factors

et al. 2003

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Interdisciplinary question generation: Synthesis and validity analysis of the 1993–1997 bovine mastitis-related literature

et al. 1998

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hlterdisciplinary synthesb and validity analysis (ISVA), a structured learning approach which integrates learning and communication theories, meta-analytic evaluation methods, and literature management-related technologies was applied in the context of the 1993-1997 bovine mastitis research literature. This study investigated whether ISVA could: 1) facilitate the analysis and synthesis of interdisciplinary knowledge claims, and 2)generate projects or research questions. The bovine mastitis-related literature was conceptualized as composed of microbiological, immunological, and epidemiological dimensions. Keywords involving these dimensions were searched in the Medline and Agricola databases. A final list of 148 articles were retrieved, analyzed, synthesized into fifteen information sub-sets, and evaluated for construct, internal, external and statistical validity through an interdisciplinary iterative dialogical process. Validity threats were re-phrased as new research or educational projects.Research on interdisciplinarity has been conducted from many paradigms. To mention a few, studies from sociology, management, organizational development, education, communication, political science and medicine, have investigated multiple aspects of interdisciplinarity. 1 However, to the best of our knowledge, no published report has integrated technology, research methodology and broad disciplinary perspectives.Addressing that need, we integrated: 1)evaluation theory; 2)education theory; 3) communication theory, 4)bibliographic management technologies, and 5)contextrelated disciplines (defined from the conceptualization of the problem being assessed).This system (interdisciplinary synthesis and validity analysis, or ISVA) was tested in the context of the bovine mastitis-related literature. Bovine intramammary infection or mastitis (IMI/M) is a complex disease which results in major economic losses for dairy agriculture. 9-12 Despite major financial efforts to prevent mastitis, the prevalence of this disease has not diminished in the last 10 years.13 Although meta-analysis has been practised extensively in social sciences and human medicine, only three rectaanalyses have been conducted in veterinary medicine. 14-16 Thus, a novel approach to address IMI/M knowledge needs appears justified.This study assessed whether ISVA could generate: a) comprehensive, updated and integrated information synthesis; and b) new research questions. Materials and methods [SVA phasesThis question generation method was composed of three phases. The first two phases involved literature synthesis and the last phase involved validity analysis.In the first or diverging phase, the research objective was conceptualized with the support of a multi-disciplinary team (which included experts in veterinary microbiology, immunology, molecular biology, epidemiology, and mastitis research). This team identified keywords to be searched and bibliographic databases, and conducted literature searches with the support of bibliographic reference management software. ...

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Considerations in the nutritional modification of milk composition

Fredeen¹

1996

Animal Feed Science and Technology

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Effect of Somatotropin on Changes in Milk Production and Composition During Coliform Mastitis in Periparturient Cows

Cited by 16 publications

References 22 publications

Severity of E. coli mastitis is mainly determined by cow factors

Severity of E. coli mastitis is mainly determined by cow factors

Interdisciplinary question generation: Synthesis and validity analysis of the 1993–1997 bovine mastitis-related literature

Considerations in the nutritional modification of milk composition

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