Effect of Sodium Gluconate on Decreasing Elevated Nasal Calcium and Improving Olfactory Function Post COVID-19 Infection

Abdelazim, Mohamed H.; Abdelazim, Ahmed H.

doi:10.1177/19458924221120116

Cited by 10 publications

(9 citation statements)

References 27 publications

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“…A series of recent blinded studies by Abdelazim et al [346][347][348] on sodium gluconate, sodium pyrophosphate, and sodium nitrilotriacetate showed a significant improvement in olfaction in patients with postviral olfactory dysfunction. A confirmation of these results, for example in a multicenter study, would certainly be desirable.…”

Section: Intranasal Calcium Buffermentioning

confidence: 98%

“…Eine Serie neuerer, verblindeter Untersuchungen von Abdelazim et al [346][347][348] zu Na-Glukonat, Na-Pyrophosphat und Na-Nitrilotriacetat zeigte eine deutliche Verbesserung des Riechvermögens bei Patient:innen mit einer postviralen Riechstörung beobachtet. Eine Bestätigung dieser Ergebnisse zum Beispiel in einer mulitzentrischen Studie wäre sicherlich wünschenswert.…”

Section: Intranasale Calciumpufferunclassified

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Riechen und Riechstörungen

Hummel

Guerra

Gunder³

et al. 2023

Laryngorhinootologie

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ZusammenfasssungDer Geruchssinn ist wichtig. Das wurde insbesondere v. a. Patient:innen mit infektbedingtem Riechverlust während der SARS-CoV2 Pandemie bewusst. Wir reagieren z. B. auf Körpergerüche unserer Mitmenschen – die Nase bestimmt/wen wir „riechen können“. Der Geruchssinn warnt uns vor Gefahren, die Wahrnehmung von Düften und die Wahrnehmung von Aromen beim Essen bedeuten Lebensqualität. Eine Anosmie muss daher ernst genommen werden. Obwohl sich olfaktorische Rezeptorneurone durch Regenerationsfähigkeit auszeichnen, sind Anosmien mit etwa 5% relativ häufig. Riechstörungen werden nach der Ursache eingeteilt (z. B. Infekte, Schädelhirntraumen, chronische Rhinosinusitis, Alter) mit den sich daraus ergebenden unterschiedlichen Therapieoptionen und Prognosen. Eine gründliche Anamnese ist deshalb bedeutsam. Zur Diagnostik stehen verschiedenste Untersuchungsverfahren zur Verfügung, von orientierenden Kurztests über ausführliche mehrdimensionale Testverfahren bis hin zu elektrophysiologischen und bildgebenden Methoden. Damit sind quantitative Riechstörungen gut erfassbar und nachverfolgbar. Bei qualitativen Riechstörungen wie der Parosmie stehen derzeit allerdings keine objektivierenden Diagnoseverfahren zur Verfügung. Die therapeutischen Möglichkeiten bei Riechstörungen sind begrenzt. Trotzdem stehen mit dem Riechtraining sowie verschiedenen additiven medikamentösen Möglichkeiten wirksame Optionen zur Verfügung. Von großer Bedeutung ist nach wie vor die Beratung und das kompetente Gespräch mit den Patient:innen.

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Section: Intranasal Calcium Buffermentioning

confidence: 98%

Section: Intranasale Calciumpufferunclassified

Riechen und Riechstörungen

Hummel

Guerra

Gunder³

et al. 2023

Laryngorhinootologie

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“… 7 , 9 Sensorineural affection was also reported due to changes in the calcium levels in the olfactory neurons, as calcium ions play an essential role in the olfaction transduction process. 10 – 12 …”

Section: Introductionmentioning

confidence: 99%

Clinical and Imaging Evaluation of COVID-19-Related Olfactory Dysfunction

Abdou

Ebada

Salem

et al. 2023

Am J Rhinol�Allergy

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Background Olfactory dysfunction has been reported in 47.85% of COVID patients. It can be broadly categorized into conductive or sensorineural olfactory loss. Conductive loss occurs due to impaired nasal air flow, while sensorineural loss implies dysfunction of the olfactory epithelium or central olfactory pathways. Objectives The aim of this study was to analyze the clinical and imaging findings in patients with COVID-related olfactory dysfunction. Additionally, the study aimed to investigate the possible mechanisms of COVID-related olfactory dysfunction. Methods The study included 110 patients with post-COVID-19 olfactory dysfunction, and a control group of 50 COVID-negative subjects with normal olfactory function. Endoscopic nasal examination was performed for all participants with special focus on the olfactory cleft. Smell testing was performed for all participants by using a smell diskettes test. Olfactory pathway magnetic resonance imaging (MRI) was done to assess the condition of the olfactory cleft and the dimensions and volume of the olfactory bulb. Results Olfactory dysfunction was not associated with nasal symptoms in 51.8% of patients. MRI showed significantly increased olfactory bulb dimensions and volume competed to controls. Additionally, it revealed olfactory cleft edema in 57.3% of patients. On the other hand, radiological evidence of sinusitis was detected in only 15.5% of patients. Conclusion The average olfactory bulb volumes were significantly higher in the patients’ group compared to the control group, indicating significant edema and swelling in the olfactory bulb in patients with COVID-related olfactory dysfunction. Furthermore, in most patients, no sinonasal symptoms such as nasal congestion or rhinorrhea were reported, and similarly, no radiological evidence of sinusitis was detected. Consequently, the most probable mechanism of COVID-related olfactory dysfunction is sensorineural loss through virus spread and damage to the olfactory epithelium and pathways.

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“…The prognosis of reduced sense of smell and taste in COVID-19 is better than in other viral infections [ 8 ]. It has been also noted that the use of sodium gluconate may improve the OD post-COVID-19 infection [ 16 ]. Considering the importance of a comprehensive investigation of COVID-19, this systematic review and meta-analysis aimed to assess olfactory and taste disorders in COVID-19 as a prognostic factor.…”

Section: Introductionmentioning

confidence: 99%

Olfactory disorders in COVID-19 patients as a prognostic factor: a systematic review

Hashemian

Rezazadeh

Doosti-Irani

et al. 2023

Egypt J Otolaryngol

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Background The reduction, loss, or impaired sense of smell and taste is common in patients with COVID-19. We aimed to investigate olfactory disorders (ODs) in patients with COVID-19 as a prognostic factor. Methods In this systematic review and meta-analysis, studies that assessed ODs in patients with COVID-19 were included. International databases, including PubMed, Embase, MEDLINE, Web of Science, and Scopus, were searched up to 20 March 2021. The random-effects model was used to combine the results of studies. Results were reported with a 95% confidence interval. Results In this study, out of 724 references, ten studies had the inclusion criteria. The odds of death in patients with the OD were 69% lower than in those without the ODs (OR = 0.31, 95% CI: 0.14, 0.69), and OD increased the odds of positive polymerase chain reaction (PCR) test (OR = 13.34, 95% CI: 4.2, 42.37). Conclusions The findings of our study showed that OD had an inverse and significant relationship with death in COVID-19 patients, and the patients with OD seemed to have a lower risk of mortality.

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Effect of Sodium Gluconate on Decreasing Elevated Nasal Calcium and Improving Olfactory Function Post COVID-19 Infection

Cited by 10 publications

References 27 publications

Riechen und Riechstörungen

Riechen und Riechstörungen

Clinical and Imaging Evaluation of COVID-19-Related Olfactory Dysfunction

Olfactory disorders in COVID-19 patients as a prognostic factor: a systematic review

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